Zobrazeno 1 - 10
of 318
pro vyhledávání: '"Joren C. Madsen"'
Autor:
Jing Zhao, Sungwook Jung, Xiaofei Li, Lushen Li, Vivek Kasinath, Hengcheng Zhang, Said N. Movahedi, Ahmad Mardini, Gianmarco Sabiu, Yoonha Hwang, Vikas Saxena, Yang Song, Bing Ma, Sophie E. Acton, Pilhan Kim, Joren C. Madsen, Peter T. Sage, Stefan G. Tullius, George C. Tsokos, Jonathan S. Bromberg, Reza Abdi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate the tolerance induced by anti-CD40L in a murine model of heart transpla
Externí odkaz:
https://doaj.org/article/bc8427fba19b4be3b7fbe037cc02ca92
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Allograft failure remains a major barrier in the field of lung transplantation and results primarily from acute and chronic rejection. To date, standard-of-care immunosuppressive regimens have proven unsuccessful in achieving acceptable long-term gra
Externí odkaz:
https://doaj.org/article/710e0f4cf3ad45d185ee015eda6b49aa
Autor:
Julian K. Horwitz, Sofia Bin, Robert L. Fairchild, Karen S. Keslar, Zhengzi Yi, Weijia Zhang, Vasile I. Pavlov, Yansui Li, Joren C. Madsen, Paolo Cravedi, Peter S. Heeger
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Erythropoietin (EPO) has multiple nonerythropoietic functions, including immune modulation, but EPO’s effects in transplantation remain incompletely understood. We tested the mechanisms linking EPO administration to prolongation of murine heterotop
Externí odkaz:
https://doaj.org/article/1b0271f84e3245dda23663c661913691
Autor:
Parth M. Patel, Margaret R. Connolly, Taylor M. Coe, Anthony Calhoun, Franziska Pollok, James F. Markmann, Lars Burdorf, Agnes Azimzadeh, Joren C. Madsen, Richard N. Pierson
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The recent dramatic advances in preventing “initial xenograft dysfunction” in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac xenotr
Externí odkaz:
https://doaj.org/article/2e745c8bbe684164a9bafb1d612a12ec
Autor:
Jing Zhao, Liwei Jiang, Mayuko Uehara, Naima Banouni, Basmah S. Al Dulaijan, Jamil Azzi, Takaharu Ichimura, Xiaofei Li, Petr Jarolim, Paolo Fiorina, Stefan G. Tullius, Joren C. Madsen, Vivek Kasinath, Reza Abdi
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
Heart transplantation is the optimal therapy for patients with end-stage heart disease, but its long-term outcome remains inadequate. Recent studies have highlighted the importance of the melanocortin receptors (MCRs) in inflammation, but how MCRs re
Externí odkaz:
https://doaj.org/article/c5e7fbcbd733432da7013381413421fa
Autor:
Wiebke Sommer, MD, Jane M. O, MD, Kurt B. Pruner, BSc, Abbas Dehnadi, DVM, Kyu Ha Huh, MD, Kortney A. Robinson, MD, Isabel Hanekamp, PhD, Ivy Rosales, MD, Alison S. Bean, BSc, Josh Paster, BSc, Tetsu Oura, MD, Rex Neal Smith, MD, Robert Colvin, MD, Gilles Benichou, PhD, Tatsuo Kawai, MD, Joren C. Madsen, MD, DPhil, James S. Allan, MD
Publikováno v:
Transplantation Direct, Vol 7, Iss 6, p e705 (2021)
Background. In kidney transplantation, long-term allograft acceptance in cynomolgus macaques was achieved using a mixed-chimerism protocol based on the clinically available reagents, rabbit anti-thymocyte globulin (ATG), and belatacept. Here, we have
Externí odkaz:
https://doaj.org/article/bd669e56c0064385a41b8fca2c2ee16e
Autor:
Chao Yang, Jifu Ge, Ivy Rosales, Qing Yuan, Edward Szuter, Ellen Acheampong, Paul S. Russell, Joren C. Madsen, Robert B. Colvin, Alessandro Alessandrini
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
In swine and nonhuman primates, kidney allografts can induce tolerance of heart allografts, leading to their long-term, immunosuppression-free survival. We refer to this phenomenon as kidney-induced cardiac allograft tolerance (KICAT). In this study,
Externí odkaz:
https://doaj.org/article/017512e7325243fcbc0d368cbe68d8d1
Autor:
Zhaohui Wang, Nathan J. Louras, Alexandre G. Lellouch, Shannon G. Pratts, Huiping Zhang, Haoyu Wang, Christene A. Huang, Curtis L. Cetrulo Jr, Joren C. Madsen, David H. Sachs, Zhirui Wang
Publikováno v:
Molecular Oncology, Vol 12, Iss 8, Pp 1374-1382 (2018)
Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4+ tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4+ Treg depletion. We have demonstrated tha
Externí odkaz:
https://doaj.org/article/3784c31b64f845d5a0921236bcaf6cfd
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
The development of immunosuppressive drugs to control adaptive immune responses has led to the success of transplantation as a therapy for end-stage organ failure. However, these agents are largely ineffective in suppressing components of the innate
Externí odkaz:
https://doaj.org/article/da7c96610ecb43c9a263e5e6578137a4
Autor:
Qing Yuan, Shanjuan Hong, Gregory Leya, Eve Roth, Georgios Tsoulfas, WW Williams, Joren C Madsen, Nahel Elias
Publikováno v:
World Journal of Transplantation. 13:44-57