Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jordy Luten"'
Publikováno v:
Journal of Controlled Release. 126:97-110
Gene therapy holds a great promise for the treatment of acquired and inherited diseases with a genetic origin that are currently incurable. Non-viral gene delivery systems are gaining recognition as an alternative to viral gene vectors for their pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3aec496c97922f97c9efac3836ae5ce
https://doi.org/10.1016/j.jconrel.2007.10.028
https://doi.org/10.1016/j.jconrel.2007.10.028
Publikováno v:
Journal of Controlled Release. 109:275-287
In recent years, increasing interest is being paid to the design of transfectants based on non-toxic and biodegradable polymers for gene therapy purposes. We recently reported on a novel, biodegradable polymer, poly(2-dimethylamino ethylamino)phospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e0a718286b250ebc6589d82c67e3cb
https://doi.org/10.1016/j.jconrel.2005.05.030
https://doi.org/10.1016/j.jconrel.2005.05.030
Autor:
C.F. van Nostrum, N.M.E. Schuurmans-Nieuwenbroek, R. van Someren, Jordy Luten, Gerben A. Koning, J. H. Van Steenis, Johan Kemmink, Wim E. Hennink, Daan J.A. Crommelin
Publikováno v:
Journal of Controlled Release. 89:483-497
Polyphosphazenes bearing cationic moieties were synthesized from poly(dichloro)phosphazene, which in turn was obtained by thermal polymerization of hexachlorocyclotriphosphazene in 1,2,4-trichlorobenzene. Next, either 2-dimethylaminoethanol (DMAE) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44895b1881dbd0a97a6d2c2641ae41a5
https://doi.org/10.1016/s0168-3659(03)00127-5
https://doi.org/10.1016/s0168-3659(03)00127-5
Publikováno v:
Organometallics, 21, 3873-3883. American Chemical Society
The influence of electronic ligand properties on the catalyst performance in the rhodium-catalyzed hydroformylation of alkenes has been investigated. Two bidentate phosphorus amidite and phosphinite ligands have been synthesized: 1,1‘-biphenyl-2,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c389ec7d63280771122ceb935d642543
https://doi.org/10.1021/om010760y
https://doi.org/10.1021/om010760y
Autor:
Jordy Luten, Jan H. van Maarseveen, Floris P. J. T. Rutjes, Henk Hiemstra, Christien A. Schortinghuis, Hans E. Schoemaker, Mandy K. S. Vink
Publikováno v:
Journal of Organic Chemistry, 67, 7869-7871. American Chemical Society
A stereodivergent route toward both diastereomeric forms of functionalized 4-hydroxypiperidines has been successfully developed. This route involves biocatalytic generation of the enantiopure starting materials followed by functionalization via N-acy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297be2891f12f1784e427c752a03b295
https://dare.uva.nl/personal/pure/en/publications/a-stereodivergent-approach-to-substituted-4hydroxypiperidines(e38f81c6-a848-4a73-a793-5647e598bde8).html
https://dare.uva.nl/personal/pure/en/publications/a-stereodivergent-approach-to-substituted-4hydroxypiperidines(e38f81c6-a848-4a73-a793-5647e598bde8).html
Publikováno v:
Molecular pharmaceutics. 5(2)
A series of cationic, methacrylamide polymers was tested for use as a biodegradable gene carrier in ovarian cancer. Tumor transfection activity of polyplexes consisting of a reporter gene and different methacrylamide polymers was assessed, after intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3406a8abfb6af382366994a0d4324839
https://pubmed.ncbi.nlm.nih.gov/18181574
https://pubmed.ncbi.nlm.nih.gov/18181574
Autor:
Wim E. Hennink, C.F. van Nostrum, Jordy Luten, A.M. de Graaff, Martin C. Lok, M.J. van Steenbergen, Herre Talsma
A new cationic biodegradable polyphosphazene was developed, bearing both pendant primary and tertiary amine side groups, poly(2-dimethylaminoethylamine-co-diaminobutane)phosphazene (poly(DMAEA-co-BA)phosphazene). PEG and PEG-folate were coupled to po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b0266d26435b3983865675d993cfe6
https://dspace.library.uu.nl/handle/1874/40410
https://dspace.library.uu.nl/handle/1874/40410
