Discovery proteomics defines androgen-regulated glycoprotein networks in prostate cancer cells, as well as putative biomarkers of prostatic diseases

Autor: Jordy J. Hsiao, Melinda M. Smits, Brandon H. Ng, Jinhee Lee, Michael E. Wright

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract Supraphysiologic androgen (SPA) inhibits cell proliferation in prostate cancer (PCa) cells by transcriptional repression of DNA replication and cell-cycle genes. In this study, quantitative glycoprotein profiling identified androgen-regulate

Externí odkaz: https://doaj.org/article/063fa1158df847fb99676f6bb59e72dc

High resolution two-dimensional liquid chromatography coupled with mass spectrometry for robust and sensitive characterization of therapeutic antibodies at the peptide level

Autor: Jordy J. Hsiao, Dwight R. Stoll, Gregory O. Staples, David C. Harmes, Ben Madigan, Hayley R. Lhotka

Publikováno v: Journal of Chromatography B. :121832

Separations of complex peptide mixtures have been a common target application for two-dimensional liquid chromatography over the last few decades. These separations have most frequently been carried out at the capillary scale, with columns on the ord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6ae99d7a2e458b2c727d7f110d238f
https://doi.org/10.1016/j.jchromb.2019.121832

BKCa channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells

Autor: Susan J. Stamnes, Krzysztof L. Hyrc, Xiaofeng Ma, Sarah K. England, Ramón A. Lorca, Michael E. Wright, Celeste M. Karch, Chinwendu Amazu, Monali Wakle-Prabagaran, Jordy J. Hsiao

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 113(16)

The large-conductance, voltage-gated, calcium (Ca(2+))-activated potassium channel (BKCa) plays an important role in regulating Ca(2+)signaling and is implicated in the maintenance of uterine quiescence during pregnancy. We used immunopurification an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614765400c958488f92a45a8a21ac2c3
https://pubmed.ncbi.nlm.nih.gov/27044074

Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility

Autor: Hiroaki Misonou, Jordy J. Hsiao, Jinhee Lee, Jiahui Wang, James S. Trimmer, Brandon H. Ng, Melinda M. Smits, Harryl D. Martinez, Jhullian J Alston, Rohini J. Jasavala, Michael E. Wright

Publikováno v: BMC cancer, vol 15, iss 1
Hsiao, JJ; Ng, BH; Smits, MM; Wang, J; Jasavala, RJ; Martinez, HD; et al.(2015). Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility. BMC Cancer, 15(1). doi: 10.1186/s12885-015-1201-5. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4pj092hv
BMC Cancer

Background Identifying cellular signaling pathways that become corrupted in the presence of androgens that increase the metastatic potential of organ-confined tumor cells is critical to devising strategies capable of attenuating the metastatic progre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa747dab836eb3153e6a67c8fcd7650a
https://escholarship.org/uc/item/4pj092hv

Fidelity of a BAC-EGFP transgene in reporting dynamic expression of IL-7Rα in T cells

Autor: Hai-Hui Xue, Thomas L. Saunders, Xinyuan Zhou, Shuyang Yu, Jordy J. Hsiao, Dahai Yu

Interleukin-7 receptor α chain (IL-7Rα)-derived signals are critical for normal T cell development, mature T cell homeostasis, and longevity of memory T cells. IL-7Rα expression in T cells is dynamically regulated at different developmental and an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023e249867676ae29d0f194de2e84188
https://europepmc.org/articles/PMC3978762/