Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jordy C.G. Van der Zwet"'
Autor:
Annelienke M. van Hulst, Jordy C.G. van der Zwet, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Marta Fiocco, Rob Pieters, Frank N. van Leeuwen, Marry M. van den Heuvel-Eibrink, Erica L.T. van den Akker, Jules P.P. Meijerink
Publikováno v:
Haematologica, Vol 109, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/579ba24a9a684d72832907d8045d45c9
Autor:
Miriam Butler, Britt M.T. Vervoort, Dorette S. van Ingen Schenau, Lieneke Jongeneel, Jordy C.G. van der Zwet, René Marke, Jules P.P. Meijerink, Blanca Scheijen, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Although long-term survival in pediatric acute lymphoblastic leukemia (ALL) currently exceeds 90%, some subgroups, defined by specific genomic aberrations, respond poorly to treatment. We previously reported that leukemias harboring deletions or muta
Externí odkaz:
https://doaj.org/article/bd62010cd4ac4cb38d96197bfa9e66ae
Autor:
Jordy C.G. van der Zwet, Valentina Cordo’, Jessica G.C.A.M. Buijs-Gladdines, Rico Hagelaar, Willem K. Smits, Eric Vroegindeweij, Laura T.M. Graus, Vera Poort, Marloes Nulle, Rob Pieters, Jules P.P. Meijerink
Publikováno v:
Haematologica, Vol 108, Iss 3 (2022)
Physiological and pathogenic interleukin-7-receptor (IL7R)-induced signaling provokes glucocorticoid resistance in a subset of patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL). Activation of downstream STAT5 has been suggested to c
Externí odkaz:
https://doaj.org/article/67b16264c0434bffacc7a8302e7a785b
Autor:
Jules P.P. Meijerink, Rob Pieters, Kirsten Canté-Barrett, Jordy C.G. van der Zwet, Valentina Cordo'
Table S1: relevant clinical trials investigating targeted therapies for T-ALL treatment: List of clinical trials investigating the targeted agents described in this review. The clinical trials listed were chosen based on the following two selection c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ebfbe4c473fe4b430604563eafa4c1
https://doi.org/10.1158/2643-3230.22542478
https://doi.org/10.1158/2643-3230.22542478
Autor:
Jules P.P. Meijerink, Rob Pieters, Kirsten Canté-Barrett, Jordy C.G. van der Zwet, Valentina Cordo'
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy characterized by aberrant proliferation of immature thymocytes. Despite an overall survival of 80% in the pediatric setting, 20% of patients with T-ALL ultimately die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1458562285e7cd254b819ae5771b4f0a
https://doi.org/10.1158/2643-3230.c.6549943.v1
https://doi.org/10.1158/2643-3230.c.6549943.v1
Autor:
Kirsten Canté-Barrett, Rob Pieters, Jordy C.G. Van Der Zwet, Valentina Cordo, Jules P.P. Meijerink
Publikováno v:
Blood Cancer Discov
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy characterized by aberrant proliferation of immature thymocytes. Despite an overall survival of 80% in the pediatric setting, 20% of patients with T-ALL ultimately die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049b212b56d90f253ffc8872bfe02b61
https://pubmed.ncbi.nlm.nih.gov/34661151
https://pubmed.ncbi.nlm.nih.gov/34661151
Autor:
Jordy C.G. Van Der Zwet, Willem K. Smits, Jessica Buijs-Gladdines, Rob Pieters, Jules P.P. Meijerink
Publikováno v:
HemaSphere, Vol 5, Iss 1, p e513 (2021)
The glucocorticoid receptor NR3C1 is essential for steroid-induced apoptosis, and deletions of this gene have been recurrently identified at disease relapse for acute lymphoblastic leukemia (ALL) patients. Here, we demonstrate that recurrent NR3C1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbe0fa9473501ba9367c1cfbda54898
https://doi.org/10.1097/hs9.0000000000000513
https://doi.org/10.1097/hs9.0000000000000513
Autor:
Josef Vormoor, Jean-Pierre Bourquin, Jordy C.G. Van Der Zwet, Britta Vormoor, Valentina Cordo, Maarten Altelaar, Jules P.P. Meijerink, Jelle Dylus, Adolfo A. Ferrando, Jan Cools, Jessica G.C.A.M. Buijs-Gladdines, Zhongli Chen, Donna O. Debets, Guido J.R. Zaman, Willem K. Smits, Beat Bornhauser, Rob Pieters, Koichi Oshima
Publikováno v:
Blood. 136:20-20
Introduction Poor prednisolone response in the induction phase of treatment is a risk-stratification marker in the current Dutch DCOG ALL-11 treatment protocol. Physiological or mutational activation of the IL7-receptor (IL7R) provokes steroid resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0773a25862c263c62fcb9782c4eee4df
https://doi.org/10.1182/blood-2020-139305
https://doi.org/10.1182/blood-2020-139305
Publikováno v:
Advances in Biological Regulation. 74:100647
In the last decade, tremendous progress in curative treatment has been made for T-ALL patients using high-intensive, risk-adapted multi-agent chemotherapy. Further treatment intensification to improve the cure rate is not feasible as it will increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56be1ae4b5631c7aad40f1afbfc29e32
https://doi.org/10.1016/j.jbior.2019.100647
https://doi.org/10.1016/j.jbior.2019.100647
Autor:
Jessica G.C.A.M. Buijs-Gladdines, Zhongli Chen, Willem K. Smits, Jordy C.G. Van Der Zwet, Jules P.P. Meijerink
Publikováno v:
Blood. 134:1292-1292
INTRODUCTION. Mutations in the IL-7R signaling pathway (e.g.IL7Ra, JAK1/3, PTPN11, NF1, STAT5B, N/KRAS or AKT) are associated with steroid resistance and inferior relapse-free survival. These mutant molecules drive strong activation of the JAK-STAT,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d25f5f755a8dd4a7c231d85dc30c6cae
https://doi.org/10.1182/blood-2019-124721
https://doi.org/10.1182/blood-2019-124721