Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Jordi Teixidó"'
Deconstructing Markush: Improving the R&D Efficiency Using Library Selection in Early Drug Discovery
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1159 (2022)
Most of the product patents claim a large number of compounds based on a Markush structure. However, the identification and optimization of new principal active ingredients is frequently driven by a simple Free Wilson approach, leading to a highly fo
Externí odkaz:
https://doaj.org/article/4837ddde11a2400c8c168ce59beb117e
Autor:
Ana Donaire-Arias, Ana Maria Montagut, Raimon Puig de la Bellacasa, Roger Estrada-Tejedor, Jordi Teixidó, José I. Borrell
Publikováno v:
Molecules, Vol 27, Iss 7, p 2237 (2022)
Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which are included in more than 5500 references (2400 p
Externí odkaz:
https://doaj.org/article/9f4f203d4d144e219e62e76151fcab96
Autor:
Victor Masip, Ángel Lirio, Albert Sánchez-López, Ana B. Cuenca, Raimon Puig de la Bellacasa, Pau Abrisqueta, Jordi Teixidó, José I. Borrell, Albert Gibert, Roger Estrada-Tejedor
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1311 (2021)
Pyrido[2,3-d]pyrimidin-7(8H)-ones have attracted widespread interest due to their similarity with nitrogenous bases found in DNA and RNA and their potential applicability as tyrosine kinase inhibitors. Such structures, presenting up to five diversity
Externí odkaz:
https://doaj.org/article/97db14f395054d2a81849d0dda3b2cac
Autor:
Juan Marcos Oliveras, Raimon Puig de la Bellacasa, Roger Estrada-Tejedor, Jordi Teixidó, José I. Borrell
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 1029 (2021)
Naphthyridines, also known as diazanaphthalenes, are a group of heterocyclic compounds that include six isomeric bicyclic systems containing two pyridine rings. 1,6-Naphthyridines are one of the members of such a family capable of providing ligands f
Externí odkaz:
https://doaj.org/article/bce2487cf99a4461a4392f308c9a4176
Autor:
Clara Recasens-Zorzo, Teresa Cardesa-Salzmann, Paolo Petazzi, Laia Ros-Blanco, Anna Esteve-Arenys, Guillem Clot, Martina Guerrero-Hernández, Vanina Rodríguez, Davide Soldini, Alexandra Valera, Alexandra Moros, Fina Climent, Eva González-Barca, Santiago Mercadal, Leonor Arenillas, Xavier Calvo, José Luís Mate, Gonzalo Gutiérrez-García, Isolda Casanova, Ramón Mangues, Alejandra Sanjuan-Pla, Clara Bueno, Pablo Menéndez, Antonio Martínez, Dolors Colomer, Roger Estrada Tejedor, Jordi Teixidó, Elias Campo, Armando López-Guillermo, José Ignacio Borrell, Luis Colomo, Patricia Pérez-Galán, Gaël Roué
Publikováno v:
Haematologica, Vol 104, Iss 4 (2019)
Constitutive activation of the chemokine receptor CXCR4 has been associated with tumor progression, invasion, and chemotherapy resistance in different cancer subtypes. Although the CXCR4 pathway has recently been suggested as an adverse prognostic ma
Externí odkaz:
https://doaj.org/article/88843c89d42f42cebc3782239583b7fd
Autor:
Àlex L González, Piotr Konieczny, Beatriz Llamusi, Estefanía Delgado-Pinar, José I Borrell, Jordi Teixidó, Enrique García-España, Manuel Pérez-Alonso, Roger Estrada-Tejedor, Rubén Artero
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178931 (2017)
Myotonic dystrophy type 1 (DM1) is a rare multisystemic disorder associated with an expansion of CUG repeats in mutant DMPK (dystrophia myotonica protein kinase) transcripts; the main effect of these expansions is the induction of pre-mRNA splicing d
Externí odkaz:
https://doaj.org/article/3e124184b21c4dae93c3e9b2b97c445a
Autor:
Guillem Jubete, Raimon Puig de la Bellacasa, Roger Estrada-Tejedor, Jordi Teixidó, José I. Borrell
Publikováno v:
Molecules, Vol 24, Iss 22, p 4161 (2019)
Pyrido[2,3-d]pyrimidines (1) are a type of privileged heterocyclic scaffolds capable of providing ligands for several receptors in the body. Among such structures, our group and others have been particularly interested in pyrido[2,3-d]pyrimidine-7(8H
Externí odkaz:
https://doaj.org/article/3259d4a1ccd1415ca2b2a4e84df3ee5c
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152049 (2016)
Non-coding RNAs play a pivotal role in a number of diseases promoting an aberrant sequestration of nuclear RNA-binding proteins. In the particular case of myotonic dystrophy type 1 (DM1), a multisystemic autosomal dominant disease, the formation of l
Externí odkaz:
https://doaj.org/article/7718f0700a244f4fafc0f2c50eb8748d
Autor:
Àlex L. González, Daniel Fernández-Remacha, José Ignacio Borrell, Jordi Teixidó, Roger Estrada-Tejedor
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 16147
The muscleblind-like protein family (MBNL) plays a prominent role in the regulation of alternative splicing. Consequently, the loss of MBNL function resulting from sequestration by RNA hairpins triggers the development of a neuromuscular disease call
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c146a52862d8b70b5aaac8b71d4bb9
Autor:
Xavier Fageda, Jordi Teixidó
Desde 2012, todas las rutas aéreas dentro del Espacio Económico Europeo (EEE) están incluidas en el mercado de emisiones de la Unión Europea (ETS por sus siglas en inglés). La evidencia empírica ha demostrado que esta política redujo las emisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293f4c89ba878d87560fff672706646d
http://hdl.handle.net/2445/191961
http://hdl.handle.net/2445/191961
