Výsledky vyhledávání - "Jordi Rodrigo"

Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors

Autor: Mouad Alami, Jean-Daniel Brion, Blandine Baratte, Marie Lawson, Claire Delehouzé, Thomas Robert, Sandrine Ruchaud, Stéphane Bach, Olivier Lozach, Jordi Rodrigo, Abdallah Hamze

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2016, 123, pp.105-114. ⟨10.1016/j.ejmech.2016.07.040⟩

International audience; We report here the synthesis, the biological evaluation and the molecular modeling studies of new imidazo[1,2-a]pyridines derivatives designed as potent kinase inhibitors. This collection was obtained from 2-aminopyridines and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb14a8d11d511ae23eb617115b6cfcd
https://pubmed.ncbi.nlm.nih.gov/27474927

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Hexylacrylate-based mixed-mode monolith, a stationary phase for the nano-HPLC separation of structurally related enkephalins

Autor: Claire Smadja, Jordi Rodrigo, Gaëlle Proczek, Ayat Abbood, Myriam Taverna, Stéphanie Descroix, Christine Herrenknecht

Publikováno v: Analytical and Bioanalytical Chemistry. 400:459-468

The potential of an in situ photopolymerized hexylacrylate-based monolithic stationary phase-bearing sulfonic acid groups was investigated by studying the chromatographic retention of small structurally related peptides (enkephalins) by nano-LC. Seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d6bfe5e799eb54c1f18f03c13616a3
https://doi.org/10.1007/s00216-011-4762-4

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Unexpected B-ring regioselective di-nitration of diosmetin, a Citrus flavonoid

Autor: Guy Lewin, Jean-Christophe Jullian, Jordi Rodrigo

Publikováno v: Tetrahedron Letters. 51:1145-1148

Nitration in position C-8 of diosmetin, an easily available citroflavonoid, was studied in order to gain access to original analogs. The one-step nitration proved impossible, as mono or di-nitration on C-2′ and C-6′ positions on the lateral B rin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccc0e0ae823bde61452d0523677c5339
https://doi.org/10.1016/j.tetlet.2009.12.062

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Subtlety of the Structure−Affinity and Structure−Efficacy Relationships around a Nonpeptide Oxytocin Receptor Agonist

Autor: Jordi Rodrigo, Thierry Durroux, Marcel Hibert, Marie-Céline Frantz, Bernard Mouillac, Laure Boudier

Publikováno v: Journal of Medicinal Chemistry. 53:1546-1562

Very few nonpeptide oxytocin agonists have currently been reported, and none of them seem suitable for the in vivo investigation of the oxytocin mediated functions. In an attempt to rationalize the design of better tools, we have systematically studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc10a1486db382918f9a3013da1085c
https://doi.org/10.1021/jm901084f

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Phe369(7.38) at human 5-HT7 receptors confers interspecies selectivity to antagonists and partial agonists

Autor: Javier Burgueño, François Dauphin, Frédéric Fabis, Alban Lepailleur, Jordi Rodrigo, José Miguel Vela, Thibault Varin, María Isabel Loza, Hugo Gutiérrez-de-Terán, José Brea, Pilar Pérez, Marián Castro, Johan Åqvist

Publikováno v: British Journal of Pharmacology. 159:1069-1081

Background and purpose: Human and rat 5-HT 7 receptors were studied with a particular emphasis on the molecular interactions involved in ligand binding, searching for an explanation to the interspecies selectivity observed for a set of compounds. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4149ee43dafe8e9de599c0e23e2d128e
https://doi.org/10.1111/j.1476-5381.2009.00481.x

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Three-dimensional model of the human urotensin-II receptor: Docking of human urotensin-II and nonpeptide antagonists in the binding site and comparison with an antagonist pharmacophore model

Autor: Nathalie Colloc'h, Jana Sopkova-de Oliveira Santos, Isabelle Milazzo-Segalas, Sylvain Rault, Ronan Bureau, Jordi Rodrigo, Elodie Lescot

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 73:173-184

Human urotensin-II (hU-II) is a cyclic peptide that plays a central role in cardiovascular homeostasis and is considered to be the most potent mammalian vasoconstrictor identified to date. It is a natural ligand of the human urotensin-II (hUT-II) rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b05a4dc6f964fc336945d07c54dd151
https://doi.org/10.1002/prot.22050

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ChemInform Abstract: Rapid Synthesis of 4-Arylchromenes from ortho-Substituted Alkynols: A Versatile Access to Restricted Isocombretastatin A-4 Analogues as Antitumor Agents

Autor: Joëlle Dubois, Abdallah Hamze, Dolor Renko, Jordi Rodrigo, Mouad Alami, Jean-Daniel Brion, Jérôme Bignon, Olivier Provot, Evelia Rasolofonjatovo

Publikováno v: ChemInform. 46

A high yield procedure for the synthesis of various functionalized 4-arylchromene derivatives [cf.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::217340f93b720fcd787df7badef25d48
https://doi.org/10.1002/chin.201523155

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Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

Autor: Jesús Giraldo, Jean-Philippe Pin, Amadeu Llebaria, Fanny Malhaire, Pauline Scholler, Cyril Goudet, Xavier Rovira, Patricia González-Bulnes, Jordi Rodrigo

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2015, 29 (1), pp.116--30. ⟨10.1096/fj.14-257287⟩

International audience; Type 4 metabotropic glutamate (mGlu4) receptors are emerging targets for the treatment of various disorders. Accordingly, numerous mGlu4-positive allosteric modulators (PAMs) have been identified, some of which also display ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200889aa0a9b8b9e098b0a511c8504af
https://hal.archives-ouvertes.fr/hal-01943324

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Probing the Reorganization of the Nicotinic Acetylcholine Receptor during Desensitization by Time-Resolved Covalent Labeling Using [3H]AC5, a Photoactivatable Agonist

Autor: Florence Kotzyba-Hibert, Maurice Goeldner, Jordi Rodrigo, Sonia Bertrand, Alexandre Mourot, Daniel Bertrand

Publikováno v: Molecular Pharmacology. 69:452-461

The structural reorganizations occurring on the nicotinic acetylcholine receptor (nAChR) during activation and subsequent desensitization have been investigated through time-resolved photoaffinity labeling using a photoactivatable nicotinic agonist.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15c83d62a4edfc1089f65a3d91c505b
https://doi.org/10.1124/mol.105.017566

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Comparative evaluation of eight docking tools for docking and virtual screening accuracy

Autor: Esther Kellenberger, Pascal Muller, Jordi Rodrigo, Didier Rognan

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 57:225-242

Eight docking programs (DOCK, FLEXX, FRED, GLIDE, GOLD, SLIDE, SURFLEX, and QXP) that can be used for either single-ligand docking or database screening have been compared for their propensity to recover the X-ray pose of 100 small-molecular-weight l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52149bad3cee9638d2bad82445d022eb
https://doi.org/10.1002/prot.20149

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