Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Jordi Rodo"'
Autor:
Estefania Casana, Veronica Jimenez, Claudia Jambrina, Victor Sacristan, Sergio Muñoz, Jordi Rodo, Ignasi Grass, Miquel Garcia, Cristina Mallol, Xavier León, Alba Casellas, Víctor Sánchez, Sylvie Franckhauser, Tura Ferré, Sara Marcó, Fatima Bosch
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 190-204 (2022)
Type 2 diabetes, insulin resistance, and obesity are strongly associated and are a major health problem worldwide. Obesity largely results from a sustained imbalance between energy intake and expenditure. Therapeutic approaches targeting metabolic ra
Externí odkaz:
https://doaj.org/article/424459a9f476495e9411067950fe1b43
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 3, Pp 190-200 (2024)
The COVID-19 pandemic has led to a rethinking of clinical trial design to maintain clinical research activity, with regulatory changes allowing for the wider implementation and development of decentralized design models. Evidence of the feasibility a
Externí odkaz:
https://doaj.org/article/2e7d70dc78b146cb9f13af5b819a680a
Autor:
Sarina A. Piha-Paul, Chieh Tseng, Cheuk Hong Leung, Ying Yuan, Daniel D. Karp, Vivek Subbiah, David Hong, Siqing Fu, Aung Naing, Jordi Rodon, Milind Javle, Jaffer A. Ajani, Kanwal P. Raghav, Neeta Somaiah, Gordon B. Mills, Apostolia M. Tsimberidou, Xiaofeng Zheng, Ken Chen, Funda Meric-Bernstam
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Cancer cells with BRCA1/2 deficiencies are sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. We evaluated the efficacy of talazoparib in DNA-Damage Repair (DDR)-altered patients. In this phase II trial, patients were enrolled onto
Externí odkaz:
https://doaj.org/article/1e0d0ae9bd434d9dbecfece7f428357b
Autor:
Alexandra Leary, Purificación Estévez-García, Renaud Sabatier, Isabelle Ray-Coquard, Margarita Romeo, Pilar Barretina-Ginesta, Marta Gil-Martin, Elena Garralda, Joaquim Bosch-Barrera, Teresa Morán, Paloma Martin-Martorell, Ernest Nadal, Pere Gascón, Jordi Rodon, Jose M Lizcano, Pau Muñoz-Guardiola, Gemma Fierro-Durán, Oriol Pedrós-Gámez, Héctor Pérez-Montoyo, Marc Yeste-Velasco, Marc Cortal, Antonio Pérez-Campos, Jose Alfon, Carles Domenech, Alejandro Pérez-Fidalgo, Ana Oaknin
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Carboplatin and paclitaxel (CP) have been the standard of care for advanced/recurrent endometrial cancer (EC) for many years. However, this chemotherapy combination shows limited efficacy and recurrences often occur in less than 1
Externí odkaz:
https://doaj.org/article/e9af8aa9cdf44687a3777adf7751ad39
Autor:
Wei Li, James Welsh, Vivek Verma, David S Hong, Nathan I Comeaux, Joe Y Chang, Jordi Rodon Ahnert, Daniel D Karp, Ecaterina E Dumbrava, Xinyan Xu, Girish S Shroff, Aileen Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)
Background BMS-986156 is an agonist of the glucocorticoid-induced tumor necrosis factor receptor (TNFR)-related protein (GITR) and promotes increased effector T-cell activation. Combined anti-GITR, anti-programmed death-1, anti-cytotoxic T-lymphocyte
Externí odkaz:
https://doaj.org/article/410ba5e120724ccebba6aa124b66d32f
Autor:
Wei He, Weiyi Peng, Si Chen, Jordi Rodon Ahnert, Jiakai Hou, Leilei Shi, Ritu Bohat, Yue Lu, Han Xu, Sana Sharif, Roshni Jaffery, Ashley Guerrero, Rongjie Fu, Ningbo Zheng, Nicholas A Egan, Chengtai Yu, Shuyue Wang, Donjeta Gjuka, Everett M Stone, Pooja Anil Shah, Taiping Chen, Xinli Liu, Mark T Bedford
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)
Background Hyperactivated protein arginine methyltransferases (PRMTs) are implicated in human cancers. Inhibiting tumor intrinsic PRMT5 was reported to potentiate antitumor immune responses, highlighting the possibility of combining PRMT5 inhibitors
Externí odkaz:
https://doaj.org/article/f2ce79b83742456784a1825a87418410
Autor:
Heather Lin, Vivek Subbiah, Siqing Fu, Aung Naing, Courtney Nicholas, Shubham Pant, Chad Tang, Michael A Curran, David S Hong, Ying Yuan, Sarina A Piha-Paul, Jordi Rodon Ahnert, Timonthy A Yap, Apostolia M Tsimberidou, Daniel D Karp, Anupallavi Srinivasamani, Coline Couillault, Genevieve P Hartley, James Dai, Ecaterina E Ileana Dumbrava, Paola Guerrero, Sarah Dhebat, Theresa Proia
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective To evaluate signal transducer and activator of transcription 3 (STAT3) inhibition we conducted a co-clinical trial testing danvatirsen, a STAT3 antisense oligonucleotide (ASO) and checkpoint inhibition in conjunction with preclinical experi
Externí odkaz:
https://doaj.org/article/fd1c2105b438497dab4139b2a44f11d7
Autor:
Carlos Ávila-Nieto, Júlia Vergara-Alert, Pep Amengual-Rigo, Erola Ainsua-Enrich, Marco Brustolin, María Luisa Rodríguez de la Concepción, Núria Pedreño-Lopez, Jordi Rodon, Victor Urrea, Edwards Pradenas, Silvia Marfil, Ester Ballana, Eva Riveira-Muñoz, Mònica Pérez, Núria Roca, Ferran Tarrés-Freixas, Guillermo Cantero, Anna Pons-Grífols, Carla Rovirosa, Carmen Aguilar-Gurrieri, Raquel Ortiz, Ana Barajas, Benjamin Trinité, Rosalba Lepore, Jordana Muñoz-Basagoiti, Daniel Perez-Zsolt, Nuria Izquierdo-Useros, Alfonso Valencia, Julià Blanco, Victor Guallar, Bonaventura Clotet, Joaquim Segalés, Jorge Carrillo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are based on a mutated version of the Spike glycoprotein [K986P/V987P
Externí odkaz:
https://doaj.org/article/417894952ca54f88947455ec8d336df7
Autor:
Jordi Rodón, David Demanse, Hope S. Rugo, Howard A. Burris, Rafael Simó, Azeez Farooki, Melissa F. Wellons, Fabrice André, Huilin Hu, Dragica Vuina, Cornelia Quadt, Dejan Juric
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Background Hyperglycemia is an on-target effect of PI3Kα inhibitors. Early identification and intervention of treatment-induced hyperglycemia is important for improving management of patients receiving a PI3Kα inhibitor like alpelisib. Her
Externí odkaz:
https://doaj.org/article/211162ffb10842579ce7426078c215cf
Autor:
Brian Maina Ogoti, Victor Riitho, Johanna Wildemann, Nyamai Mutono, Julia Tesch, Jordi Rodon, Kaneemozhe Harichandran, Jackson Emanuel, Elisabeth Möncke-Buchner, Stella Kiambi, Julius Oyugi, Marianne Mureithi, Victor M. Corman, Christian Drosten, Samuel M. Thumbi, Marcel A. Müller
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 3, Pp 581-585 (2024)
Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in dromedaries in Africa, but camel-to-human transmission is limited. Sustained 12-month sampling of dromedaries in a Kenya abattoir hub showed biphasic MERS-CoV incidence; peak detec
Externí odkaz:
https://doaj.org/article/12e88a5687aa49c68692c936c399ff61