Výsledky vyhledávání - "Jordi Requena"

Akademický článek

Proteomic Analysis of Human iPSC-Derived Neural Stem Cells and Motor Neurons Identifies Proteasome Structural Alterations

Autor: Iñaki Álvarez, Adrián Tirado-Herranz, Belén Alvarez-Palomo, Jordi Requena Osete, Michael J. Edel

Publikováno v: Cells, Vol 12, Iss 24, p 2800 (2023)

Background: Proteins targeted by the ubiquitin proteasome system (UPS) are identified for degradation by the proteasome, which has been implicated in the development of neurodegenerative diseases. Major histocompatibility complex (MHC) molecules pres

Externí odkaz: https://doaj.org/article/875d4facc8024f988990703a5870360c

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Akademický článek

A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia

Autor: Attila Szabo, Ibrahim A. Akkouh, Matthieu Vandenberghe, Jordi Requena Osete, Timothy Hughes, Vivi Heine, Olav B. Smeland, Joel C. Glover, Ole A. Andreassen, Srdjan Djurovic

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent stem cell (iPSC)-deri

Externí odkaz: https://doaj.org/article/15f6e60079fa4543be5cc7f80fc3bf5a

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Akademický článek

Using iPSC Models to Understand the Role of Estrogen in Neuron–Glia Interactions in Schizophrenia and Bipolar Disorder

Autor: Denis Reis de Assis, Attila Szabo, Jordi Requena Osete, Francesca Puppo, Kevin S. O’Connell, Ibrahim A. Akkouh, Timothy Hughes, Evgeniia Frei, Ole A. Andreassen, Srdjan Djurovic

Publikováno v: Cells, Vol 10, Iss 2, p 209 (2021)

Schizophrenia (SCZ) and bipolar disorder (BIP) are severe mental disorders with a considerable disease burden worldwide due to early age of onset, chronicity, and lack of efficient treatments or prevention strategies. Whilst our current knowledge is

Externí odkaz: https://doaj.org/article/43df122af6e3483db6201c3ed8820e33

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Akademický článek

Effects of the Post-Spinal Cord Injury Microenvironment on the Differentiation Capacity of Human Neural Stem Cells Derived from Induced Pluripotent Stem Cells

Autor: Clara López-Serrano, Abel Torres-Espín, Joaquim Hernández, Ana B. Alvarez-Palomo, Jordi Requena, Xavier Gasull, Michael J. Edel, Xavier Navarro

Publikováno v: Cell Transplantation, Vol 25 (2016)

Spinal cord injury (SCI) causes loss of neural functions below the level of the lesion due to interruption of spinal pathways and secondary neurodegenerative processes. The transplant of neural stem cells (NSCs) is a promising approach for the repair

Externí odkaz: https://doaj.org/article/047e341fab0946e0919b705c0c2b5178

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