Zobrazeno 1 - 10 of 98 pro vyhledávání: '"Jordi Frigola"'
1
Akademický článek
Stabilisation of half MCM ring by Cdt1 during DNA insertion
Autor: Marina Guerrero-Puigdevall, Narcis Fernandez-Fuentes, Jordi Frigola
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
During pre-Replication Complex, eukaryotic cells load two MCMs into a head-to-head Double Hexamer around duplex DNA (DH). Here the authors preRC assembly assay with purified proteins to reveal insights into S. cerevisiae’s first steps that lead to
Externí odkaz: https://doaj.org/article/2a3a272cd120490cb93389b9e9ed49dd
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2
Akademický článek
Cdt1 stabilizes an open MCM ring for helicase loading
Autor: Jordi Frigola, Jun He, Kerstin Kinkelin, Valerie E. Pye, Ludovic Renault, Max E. Douglas, Dirk Remus, Peter Cherepanov, Alessandro Costa, John F. X. Diffley
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The loading and activation of the Mcm2-7 replicative helicase couples cell cycle progression to DNA replication. Here the authors use X-ray crystallography and single-particle electron microscopy to demonstrate how Ctd1 functions to promote MCM loadi
Externí odkaz: https://doaj.org/article/cb03dbf473dc4d6197f8ab99b9768f4a
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3
Data from Chromosomal Instability Correlates with Genome-wide DNA Demethylation in Human Primary Colorectal Cancers
Autor: Miguel A. Peinado, Maria Ribas, Gabriel Capellà, Manel Esteller, Victor Moreno, Cristina Morales, Mario F. Fraga, Rosa-Ana Risques, Elisenda Vendrell, Jordi Frigola, Jairo Rodriguez
DNA hypomethylation is a common trait of colorectal cancer. Studies in tumor cell lines and animal models indicate that genome-wide demethylation may cause genetic instability and hence facilitate or accelerate tumor progression. Recent studies have
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98f7f19a2b44b5dadce56b680d42657
https://doi.org/10.1158/0008-5472.c.6494136
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6
Stabilisation of half MCM ring by Cdt1 during DNA insertion
Autor: Jordi Frigola, Marina Guerrero-Puigdevall, Narcis Fernandez-Fuentes
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Origin licensing ensures precise once per cell cycle replication in eukaryotic cells. The Origin Recognition Complex, Cdc6 and Cdt1 load Mcm2-7 helicase (MCM) into a double hexamer, bound around duplex DNA. The complex formed by ORC-Cdc6 bound to dup
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba868c1b93225e26813ac08bc4071ba
https://doaj.org/article/2a3a272cd120490cb93389b9e9ed49dd
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7
Akademický článek
1,2-Diaryl(3-pyridyl)ethanone Oximes. Intermolecular Hydrogen Bonding Networks Revealed by X-ray Diffraction
Autor: Santiago García-Granda, Jordi Frigola, Rosa Cuberes, Carmen Alvarez-Rúa, Neus Mesquida, Ermitas Alcalde
Publikováno v: Molecules, Vol 13, Iss 2, Pp 301-318 (2008)
The synthesis of a set of 1-aryl-2-aryl(3-pyridyl)ethanones 1-5 and thecorresponding ketoximes 6-9 is reported. Structural studies of oximes 6, 7 and 9 wereperformed in solution using 1H-NMR and in the solid state by X-ray crystallography,providing e
Externí odkaz: https://doaj.org/article/8bae00336b4c442d9461358d6d118606
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8
Cdt1 stabilizes an open MCM ring for helicase loading
Autor: Alessandro Costa, John F.X. Diffley, Ludovic Renault, Jordi Frigola, Dirk Remus, Max E. Douglas, Valerie E. Pye, Peter Cherepanov, Jun He, Kerstin Kinkelin
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
'Nature Communications ', vol: 8, pages: 15720-1-15720-10 (2017)
ORC, Cdc6 and Cdt1 act together to load hexameric MCM, the motor of the eukaryotic replicative helicase, into double hexamers at replication origins. Here we show that Cdt1 interacts with MCM subunits Mcm2, 4 and 6, which both destabilizes the Mcm2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52616a799372d69222b43817ac94fb6
http://hdl.handle.net/10044/1/50019
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9
Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase
Autor: John F.X. Diffley, Fabienne Beuron, Edward P. Morris, Gideon Coster, Jordi Frigola
Publikováno v: Molecular Cell
Summary Loading of the six related Minichromosome Maintenance (MCM) proteins as head-to-head double hexamers during DNA replication origin licensing is crucial for ensuring once-per-cell-cycle DNA replication in eukaryotic cells. Assembly of these pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949ab2f9deda6b74d0f34a794393ccb4
https://doi.org/10.1016/j.molcel.2014.06.034
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10
ATPase-dependent quality control of DNA replication origin licensing
Autor: Jordi Frigola, Dirk Remus, Amina Mehanna, John F.X. Diffley
Publikováno v: Nature
The regulated loading of the Mcm2-7 DNA helicase (comprising six related subunits, Mcm2 to Mcm7) into pre-replicative complexes at multiple replication origins ensures precise once per cell cycle replication in eukaryotic cells. The origin recognitio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4933baa2e69ff887d9093058eff434b
https://doi.org/10.1038/nature11920
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