Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jordi Creus‐Muncunill"'
Autor:
Jordi Creus-Muncunill, Jean Vianney Haure-Mirande, Daniele Mattei, Joanna Bons, Angie V. Ramirez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa M. Ellerby, Michelle E. Ehrlich
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-26 (2024)
Abstract Introduction Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the Huntingtin gene (HTT). Immune activation is abundant in the striatum of HD patients. Detection of ac
Externí odkaz:
https://doaj.org/article/b2af945c340e484f850a0185183190e3
Autor:
Amelia D. Dunn, Shivon A. Robinson, Chiso Nwokafor, Molly Estill, Julia Ferrante, Li Shen, Crystal O. Lemchi, Jordi Creus-Muncunill, Angie Ramirez, Juliet Mengaziol, Julia K. Brynildsen, Mark Leggas, Jamie Horn, Michelle E. Ehrlich, Julie A. Blendy
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
IntroductionInfants exposed to opioids in utero are at high risk of exhibiting Neonatal Opioid Withdrawal Syndrome (NOWS), a combination of somatic withdrawal symptoms including high pitched crying, sleeplessness, irritability, gastrointestinal distr
Externí odkaz:
https://doaj.org/article/5c02e79f5cd44978b1bd5dd7551f72ee
Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease
Autor:
Rafael Alcalá‐Vida, Marta Garcia‐Forn, Carla Castany‐Pladevall, Jordi Creus‐Muncunill, Yoko Ito, Enrique Blanco, Arantxa Golbano, Kilian Crespí‐Vázquez, Aled Parry, Guy Slater, Shamith Samarajiwa, Sandra Peiró, Luciano Di Croce, Masashi Narita, Esther Pérez‐Navarro
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-25 (2020)
Abstract Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (HD), a CAG repeat‐associated neurodegenerative disorde
Externí odkaz:
https://doaj.org/article/127bba476357472aa2d34c9d8e7f0916
Autor:
Mads E. Hauberg, Jordi Creus-Muncunill, Jaroslav Bendl, Alexey Kozlenkov, Biao Zeng, Chuhyon Corwin, Sarah Chowdhury, Harald Kranz, Yasmin L. Hurd, Michael Wegner, Anders D. Børglum, Stella Dracheva, Michelle E. Ehrlich, John F. Fullard, Panos Roussos
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Here, the authors perform ATAC-seq on four distinct cell populations from three different regions of the human brain, finding that chromatin accessibility varies greatly by cell type and less by brain region. This study reveals differences in biologi
Externí odkaz:
https://doaj.org/article/91a74a493df14309930cea9170546613
Autor:
Maria-Daniela Cirnaru, Sicheng Song, Kizito-Tshitoko Tshilenge, Chuhyon Corwin, Justyna Mleczko, Carlos Galicia Aguirre, Houda Benlhabib, Jaroslav Bendl, Pasha Apontes, John Fullard, Jordi Creus-Muncunill, Azadeh Reyahi, Ali M Nik, Peter Carlsson, Panos Roussos, Sean D Mooney, Lisa M Ellerby, Michelle E Ehrlich
Publikováno v:
eLife, Vol 10 (2021)
Many diseases are linked to dysregulation of the striatum. Striatal function depends on neuronal compartmentation into striosomes and matrix. Striatal projection neurons are GABAergic medium spiny neurons (MSNs), subtyped by selective expression of r
Externí odkaz:
https://doaj.org/article/301679f6c49048c8a4afba920502c74a
Autor:
Sicheng Song, Jordi Creus Muncunill, Carlos Galicia Aguirre, Kizito-Tshitoko Tshilenge, B. Wade Hamilton, Akos A. Gerencser, Houda Benlhabib, Maria-Daniela Cirnaru, Mark Leid, Sean D. Mooney, Lisa M. Ellerby, Michelle E. Ehrlich
Publikováno v:
Biomedicines; Volume 10; Issue 10; Pages: 2377
The dysregulation of striatal gene expression and function is linked to multiple diseases, including Huntington’s disease (HD), Parkinson’s disease, X-linked dystonia-parkinsonism (XDP), addiction, autism, and schizophrenia. Striatal medium spiny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5269963b195fcca2eca3006eaa135ce5
Autor:
Jaime L. Watson, Pedro Gonzalez-Alegre, Michelle E. Ehrlich, Shareen Nelson, Travis B. Lewis, Maria-Daniela Cirnaru, Lisa M. Ellerby, Jordi Creus-Muncunill
Publikováno v:
Movement Disorders. 36:2780-2794
Background X-linked dystonia parkinsonism is a generalized, progressive dystonia followed by parkinsonism with onset in adulthood and accompanied by striatal neurodegeneration. Causative mutations are located in a noncoding region of the TATA-box bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9b54687feb122427f716f2bfa225e4
https://doi.org/10.1002/mds.28750
https://doi.org/10.1002/mds.28750
Autor:
Anna Guisado-Corcoll, Maria Solaguren-Beascoa, Geòrgia Escaramís, Jordi Creus-Muncunill, Cristina Navarrete, Esther Pérez-Navarro, Veronica Venturi, Eulàlia Martí, Daniela Diaz-Lucena, Franc Llorens, Marta García de Herreros, Mercè Masana, Ana Gámez-Valero, Lorena Pantano
Publikováno v:
Acta Neuropathologica. 141:565-584
Progressive motor alterations and selective death of striatal medium spiny neurons (MSNs) are key pathological hallmarks of Huntington's disease (HD), a neurodegenerative condition caused by a CAG trinucleotide repeat expansion in the coding region o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80f37bb7a82db92a3da88436482eaf39
https://doi.org/10.1007/s00401-021-02272-9
https://doi.org/10.1007/s00401-021-02272-9
Autor:
Brian S. Muntean, Michelle E. Ehrlich, Maria Daniela Cirnaru, Genevieve Beauvais, Garrett Otrimski, Chiara Melis, Pedro Gonzalez-Alegre, Jordi Creus-Muncunill, Kirill A. Martemyanov
Publikováno v:
Movement Disorders. 36:1147-1157
Background Similar to some monogenic forms of dystonia, levodopa-induced dyskinesia is a hyperkinetic movement disorder with abnormal nigrostriatal dopaminergic neurotransmission. Molecularly, it is characterized by hyper-induction of phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd62c7f9ee8d16a5cbc2f63a1794d84
https://doi.org/10.1002/mds.28476
https://doi.org/10.1002/mds.28476
Autor:
Julia R. Ferrante, Amelia D. Dunn, Juliet Mengaziol, Julia Noreck, Crystal O. Lemchi, Jordi Creus‐Muncunill, Michelle E. Ehrlich, Julie A. Blendy
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a38c4ced2c7495241dd6c2b36bd6193f
https://doi.org/10.1096/fasebj.2022.36.s1.r4002
https://doi.org/10.1096/fasebj.2022.36.s1.r4002