Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Jordi Bonaventura"'
Autor:
Marie A. Labouesse, Arturo Torres-Herraez, Muhammad O. Chohan, Joseph M. Villarin, Julia Greenwald, Xiaoxiao Sun, Mysarah Zahran, Alice Tang, Sherry Lam, Jeremy Veenstra-VanderWeele, Clay O. Lacefield, Jordi Bonaventura, Michael Michaelides, C. Savio Chan, Ofer Yizhar, Christoph Kellendonk
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent studies have re-established that dSP
Externí odkaz:
https://doaj.org/article/81d980c17c3448e59ac7e2551e221f37
Autor:
Jacqueline D. Keighron, Jordi Bonaventura, Yang Li, Jae-Won Yang, Emily M. DeMarco, Melinda Hersey, Jianjing Cao, Walter Sandtner, Michael Michaelides, Harald H. Sitte, Amy Hauck Newman, Gianluigi Tanda
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the dopamine transporter (DAT) to form ligand-transporter complexes, resulting in markedly different effects on behavior, neurochemistry, and potential f
Externí odkaz:
https://doaj.org/article/b76b51eca73a4f0bb45544c468f3d7ee
Autor:
Montse Flores-García, Laura Sarasola, África Flores De Los Heros, Jennifer Grau-Sánchez, Antoni Rodríguez-Fornells, Sebastià Videla, Ester Aso, Jordi Bonaventura, Víctor Fernández-Dueñas
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S561-S562 (2023)
Externí odkaz:
https://doaj.org/article/51f9abe2b82644cfb23a453a09230b01
Autor:
Arianna Rizzo, Zelai Garçon-Poca, Montse Flores-García, África Flores De Los Heros, Víctor Fernández-Dueñas, Jordi Bonaventura
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S333- (2023)
Externí odkaz:
https://doaj.org/article/ffda5e24a1014610be85771d529ba77c
Autor:
Montse Flores-García, Arianna Rizzo, Maria Zelai Garçon-Poca, Víctor Fernández-Dueñas, Jordi Bonaventura
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Chronic pain and depression are highly prevalent pathologies and cause a major socioeconomic burden to society. Chronic pain affects the emotional state of the individuals suffering from it, while depression worsens the prognosis of chronic pain pati
Externí odkaz:
https://doaj.org/article/47ced77d2aa0489a911996a3203adf78
Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior
Autor:
Juan L. Gomez, Jordi Bonaventura, Jacqueline Keighron, Kelsey M. Wright, Dondre L. Marable, Lionel A. Rodriguez, Sherry Lam, Meghan L. Carlton, Randall J. Ellis, Chloe J. Jordan, Guo-hua Bi, Oscar Solis, Marco Pignatelli, Michael J. Bannon, Zheng-Xiong Xi, Gianluigi Tanda, Michael Michaelides
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown. We found that Zn2+ concentrations in postmorte
Externí odkaz:
https://doaj.org/article/7c2c5e8de1754235a1d3f93bf616dd57
Autor:
Sergi Ferré, Annabelle M. Belcher, Jordi Bonaventura, César Quiroz, Marta Sánchez-Soto, Verònica Casadó-Anguera, Ning-Sheng Cai, Estefanía Moreno, Comfort A. Boateng, Thomas M. Keck, Benjamín Florán, Christopher J. Earley, Francisco Ciruela, Vicent Casadó, Marcelo Rubinstein, Nora D. Volkow
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The functional and pharmacological significance of the dopamine D4 receptor (D4R) has remained the least well understood of all the dopamine receptor subtypes. Even more enigmatic has been the role of the very prevalent human DRD4 gene polymorphisms
Externí odkaz:
https://doaj.org/article/296e48e160894ee886f69c1f180469c2
Autor:
Jordi Bonaventura, Mark A. G. Eldridge, Feng Hu, Juan L. Gomez, Marta Sanchez-Soto, Ara M. Abramyan, Sherry Lam, Matthew A. Boehm, Christina Ruiz, Mitchell R. Farrell, Andrea Moreno, Islam Mustafa Galal Faress, Niels Andersen, John Y. Lin, Ruin Moaddel, Patrick J. Morris, Lei Shi, David R. Sibley, Stephen V. Mahler, Sadegh Nabavi, Martin G. Pomper, Antonello Bonci, Andrew G. Horti, Barry J. Richmond, Michael Michaelides
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks. Here the authors report two novel high-potency DREADD ligands and a novel DREAD
Externí odkaz:
https://doaj.org/article/61041765c18b4742add3c9f64f5d7580
Autor:
Xavier Guitart, Jordi Bonaventura, William Rea, Marco Orrú, Lucrezia Cellai, Ilaria Dettori, Felicita Pedata, Marc Brugarolas, Antonio Cortés, Vicent Casadó, Ching-Pang Chang, Manikandan Narayanan, Yijuang Chern, Sergi Ferré
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 47-53 (2016)
The initial goal of this study was to investigate alterations in adenosine A2A receptor (A2AR) density or function in a rat model of Huntington disease (HD) with reported insensitivity to an A2AR antagonist. Unsuspected negative results led to the hy
Externí odkaz:
https://doaj.org/article/5f0fc91ff1fc465fa5369d2dd9737a1f
Autor:
Sergi Ferré, Jordi Bonaventura, Wendy Zhu, Candice Hatcher-Solis, Jaume Taura, César Quiroz, Ning-Sheng Cai, Estefanía Moreno, Verónica Casadó-Anguera, Alexxai V. Kravitz, Kimberly R. Thompson, Dardo G. Tomasi, Gemma Navarro, Arnau Cordomí, Leonardo Pardo, Carme Lluís, Carmen W. Dessauer, Nora D. Volkow, Vicent Casadó, Francisco Ciruela, Diomedes E. Logothetis, Daniel Zwilling
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The central adenosine system and adenosine receptors play a fundamental role in the modulation of dopaminergic neurotransmission. This is mostly achieved by the strategic co-localization of different adenosine and dopamine receptor subtypes in the tw
Externí odkaz:
https://doaj.org/article/38b2b15a7fb34720abd17bdefcd1f850