Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Jordi Bach"'
Autor:
Hongquan Qin, Jiali Chen, Katia Bouchekioua-Bouzaghou, Ya-Ming Meng, Jordi Bach Griera, Xue Jiang, Xiangzhan Kong, Minghui Wang, Qiuping Xu, Ping-Pui Wong
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is characterised by limited responses to chemoimmunotherapy attributed to highly desmoplastic tumor microenvironment. Disrupting the tumor-stromal cell crosstalk is considered as an improved
Externí odkaz:
https://doaj.org/article/57f8cb11ec2f4207954cfdc131aa223a
Akademický článek
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Publikováno v:
Metallomics. 12:2161-2173
Arsenic induces oncogenic effects activating stress-related signalling pathways. This can result in the over-activation of the AP-1 protein, specifically its FRA1 component. FRA1 is a transcription factor frequently overexpressed in epithelial tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87a356cdc1dd26cecc26817151b29134
https://doi.org/10.1039/d0mt00209g
https://doi.org/10.1039/d0mt00209g
Autor:
Silvia Fonquerna, Paul R. Eastwood, Adela Orellana, Jorge De Alba, Elena Calama, Cristina Carreño, Joan Albertí, Isabel Ramis, Ana Andrés, Neus Prats, Elena Gómez, Elena Calaf, Jacob González, M. I. Maldonado, Montserrat Miralpeix, Marta Calbet, Juan J. Perez, J. A. Alonso, Jordi Bach, Estrella Lozoya
Publikováno v:
Journal of Medicinal Chemistry. 62:9045-9060
Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bfc9410f7ec3edc9e56b10bcf7038d
https://doi.org/10.1021/acs.jmedchem.9b00533
https://doi.org/10.1021/acs.jmedchem.9b00533
Publikováno v:
Metallomics : integrated biometal science. 12(12)
Arsenic induces oncogenic effects activating stress-related signalling pathways. This can result in the over-activation of the AP-1 protein, specifically its FRA1 component. FRA1 is a transcription factor frequently overexpressed in epithelial tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98cfeadc30e6b41d4578719737e7a3ad
https://pubmed.ncbi.nlm.nih.gov/33313624
https://pubmed.ncbi.nlm.nih.gov/33313624
Publikováno v:
Nanomedicine. 12:2623-2635
Aim: Since controversial results have been obtained in studies dealing with nanoceria usefulness in biomedical applications, the transforming effects of long-term exposure to nanoceria in lung epithelial cells, alone or together with cigarette smoke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960385501825f04c4fc0ea13e82c9087
https://doi.org/10.2217/nnm-2017-0205
https://doi.org/10.2217/nnm-2017-0205
Publikováno v:
Toxicology and Applied Pharmacology. 409:115303
DNA damage plays a crucial role in the transforming potential of the human carcinogen arsenic. The arsenic biotransformation enzyme AS3MT is known to participate in the generation of ROS after arsenic exposure, whereas MTH1 sanitizes oxidized dNTP po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f09c81b70280ec0501f4c094675d8a2
https://doi.org/10.1016/j.taap.2020.115303
https://doi.org/10.1016/j.taap.2020.115303
Publikováno v:
Archives of Toxicology. 90:1893-1905
Chronic exposure to arsenic is known to increase the incidence of cancer in humans. Our previous work demonstrated that environmentally relevant arsenic exposures generate an accelerated accumulation of pre-carcinogen 8-OH-dG DNA lesions under Ogg1-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3530e579ececeb37f3fdbe2da355abe8
https://doi.org/10.1007/s00204-015-1605-7
https://doi.org/10.1007/s00204-015-1605-7
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 779:144-151
Inorganic arsenic (i-As) is a genotoxic and carcinogenic environmental contaminant known to affect millions of people worldwide. Our previous work demonstrated that chronic sub-toxic i-As concentrations were able to induce biologically significant le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97ac07add0b77d70d28f87f10097503
https://doi.org/10.1016/j.mrfmmm.2015.07.004
https://doi.org/10.1016/j.mrfmmm.2015.07.004
Autor:
Mar Gomis-Pastor, Jesús Berdún, Alicia Borrás-Santos, Anna De Dios López, Beatriz Fernández-Montells Rama, Óscar García-Esquirol, Mònica Gratacòs, Gerardo D. Ontiveros Rodríguez, Rebeca Pelegrín Cruz, Jordi Real, Jordi Bachs i Ferrer, Adrià Comella
Publikováno v:
Healthcare, Vol 12, Iss 11, p 1057 (2024)
Digital health technologies (DHTs) at the intersection of health, medical informatics, and business aim to enhance patient care through personalised digital approaches. Ensuring the efficacy and reliability of these innovations demands rigorous clini
Externí odkaz:
https://doaj.org/article/49f144d43d934c029d7e845146d2cf1a