Integrin-specific mechanoresponses to compression and extension probed by cylindrical flat-ended AFM tips in lung cells.

Autor: Irene Acerbi, Tomás Luque, Alícia Giménez, Marta Puig, Noemi Reguart, Ramon Farré, Daniel Navajas, Jordi Alcaraz

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32261 (2012)

Cells from lung and other tissues are subjected to forces of opposing directions that are largely transmitted through integrin-mediated adhesions. How cells respond to force bidirectionality remains ill defined. To address this question, we nanofabri

Externí odkaz: https://doaj.org/article/374bd467644b4b2cba9b9d7311a6ba2b

Lung Micrometastases Display ECM Depletion and Softening While Macrometastases Are 30-Fold Stiffer and Enriched in Fibronectin

Autor: Maria Narciso, África Martínez, Constança Júnior, Natalia Díaz-Valdivia, Anna Ulldemolins, Massimiliano Berardi, Kate Neal, Daniel Navajas, Ramon Farré, Jordi Alcaraz, Isaac Almendros, Núria Gavara

Publikováno v: Narciso, M, Martínez, Á, Júnior, C, Díaz-Valdivia, N, Ulldemolins, A, Berardi, M, Neal, K, Navajas, D, Farré, R, Alcaraz, J, Almendros, I & Gavara, N 2023, ' Lung Micrometastases Display ECM Depletion and Softening While Macrometastases Are 30-Fold Stiffer and Enriched in Fibronectin ', Cancers, vol. 15, no. 8, 2404, pp. 1-27 . https://doi.org/10.3390/cancers15082404
Cancers, 15(8):2404, 1-27. MDPI Multidisciplinary Digital Publishing Institute
Cancers; Volume 15; Issue 8; Pages: 2404

Mechanical changes in tumors have long been linked to increased malignancy and therapy resistance and attributed to mechanical changes in the tumor extracellular matrix (ECM). However, to the best of our knowledge, there have been no mechanical studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f8dfd629369d68232b55e8a4a017aa
https://research.vu.nl/en/publications/3e857371-2ba7-4326-bfd3-d2cafe379c55

Supplementary Figures from Epigenetic SMAD3 Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma

Autor: Jordi Alcaraz, Noemí Reguart, Frank Hilberg, Cristina Fillat, Pere Gascon, Victor Ivo Peinado, Eduard Monsó, Manel Esteller, Luis M. Montuenga, Laura Soucek, Toni Jauset, Sabrina Gea-Sorli, Gemma Fuster, Manuel Castro, Sebastian Morán, Albert Marín, Iuliana-Cristiana Luis, Marselina Arshakyan, Paloma Bragado, Miguel Vizoso, Paula Duch, Marta Gabasa, Rafael Ikemori

Supplementary Figures S1-S7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56afb2c2cae0c40addd1202a97a32f0e
https://doi.org/10.1158/0008-5472.22425150

Data from Epigenetic SMAD3 Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma

Autor: Jordi Alcaraz, Noemí Reguart, Frank Hilberg, Cristina Fillat, Pere Gascon, Victor Ivo Peinado, Eduard Monsó, Manel Esteller, Luis M. Montuenga, Laura Soucek, Toni Jauset, Sabrina Gea-Sorli, Gemma Fuster, Manuel Castro, Sebastian Morán, Albert Marín, Iuliana-Cristiana Luis, Marselina Arshakyan, Paloma Bragado, Miguel Vizoso, Paula Duch, Marta Gabasa, Rafael Ikemori

The tumor-promoting fibrotic stroma rich in tumor-associated fibroblasts (TAF) is drawing increased therapeutic attention. Intriguingly, a trial with the antifibrotic drug nintedanib in non–small cell lung cancer reported clinical benefits in adeno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7a12173d12743c4be33a01a3b0319fa
https://doi.org/10.1158/0008-5472.c.6511959.v1

Pattern-based Autotuning of OpenMP Loops using Graph Neural Networks

Autor: Akash Dutta, Jordi Alcaraz, Ali TehraniJamsaz, Anna Sikora, Eduardo Cesar, Ali Jannesari

Publikováno v: 2022 IEEE/ACM International Workshop on Artificial Intelligence and Machine Learning for Scientific Applications (AI4S).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2e5f7765f8ca056a76801f48b08ad1b
https://doi.org/10.1109/ai4s56813.2022.00010