Výsledky vyhledávání - "Jordi, Calderó"

Akademický článek

ERK MAPK signaling pathway inhibition as a potential target to prevent autophagy alterations in Spinal Muscular Atrophy motoneurons

Autor: Alba Sansa, Maria P. Miralles, Maria Beltran, Ferran Celma-Nos, Jordi Calderó, Ana Garcera, Rosa M. Soler

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)

Abstract Spinal Muscular Atrophy (SMA) is a severe genetic neuromuscular disorder that occurs in childhood and is caused by misexpression of the survival motor neuron (SMN) protein. SMN reduction induces spinal cord motoneuron (MN) degeneration, whic

Externí odkaz: https://doaj.org/article/7f17bffa2fa34d3ba5d982e79730d9e4

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Akademický článek

SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models

Autor: Julio Franco-Espin, Alaó Gatius, José Ángel Armengol, Saravanan Arumugam, Mehri Moradi, Michael Sendtner, Jordi Calderó, Lucia Tabares

Publikováno v: Biomolecules, Vol 12, Iss 10, p 1524 (2022)

Survival motor neuron (SMN) is an essential and ubiquitously expressed protein that participates in several aspects of RNA metabolism. SMN deficiency causes a devastating motor neuron disease called spinal muscular atrophy (SMA). SMN forms the core o

Externí odkaz: https://doaj.org/article/e83a86571ee14ac9af4a32f71c832cd4

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Akademický článek

The Y172 Monoclonal Antibody Against p-c-Jun (Ser63) Is a Marker of the Postsynaptic Compartment of C-Type Cholinergic Afferent Synapses on Motoneurons

Autor: Alaó Gatius, Olga Tarabal, Paula Cayuela, Anna Casanovas, Lídia Piedrafita, Sara Salvany, Sara Hernández, Rosa M. Soler, Josep E. Esquerda, Jordi Calderó

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2020)

C-bouton-type cholinergic afferents exert an important function in controlling motoneuron (MN) excitability. During the immunocytochemical analysis of the role of c-Jun in MNs with a monoclonal (clone Y172) antibody against phospho (p)-c-Jun (serine

Externí odkaz: https://doaj.org/article/d9a5ed111f1149e9bcc1c18a5b5a6aa6

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Akademický článek

Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus

Autor: Olga Tapia, Josep Oriol Narcís, Javier Riancho, Olga Tarabal, Lídia Piedrafita, Jordi Calderó, Maria T. Berciano, Miguel Lafarga

Publikováno v: Neurobiology of Disease, Vol 108, Iss , Pp 83-99 (2017)

Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs). The best known functions of SMN is t

Externí odkaz: https://doaj.org/article/d29a7e6ca2354071a854fdf4b26a833a

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Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury

Autor: Lídia Piedrafita, Josep E. Esquerda, Jordi Calderó, Anna Casanovas, Olga Tarabal, Sara Salvany, Sara B. Hernández

Publikováno v: Glia
Repositorio Abierto de la UdL
Universitad de Lleida
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Recercat. Dipósit de la Recerca de Catalunya
instname

Peripheral nerve section with subsequent disconnection of motor neuron (MN) cell bodies from their skeletal muscle targets leads to a rapid reactive response involving the recruitment and activation of microglia. In addition, the loss of afferent syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c234cf66851d4cd0dda9cc68e0add51e
https://doi.org/10.1002/glia.23959

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Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1 G93A mouse model of amyotrophic lateral sclerosis

Autor: Sara Salvany, Anna Casanovas, Lídia Piedrafita, Sílvia Gras, Jordi Calderó, Josep E. Esquerda

Publikováno v: Brain Pathology. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3cc27084cc452d5a8a331af48eb28f2
https://doi.org/10.1111/bpa.13078

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Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice

Autor: Xavier Navarro, Alba Blasco, Tapas Das, Ricardo Rueda, Lídia Piedrafita, Josep E. Esquerda, Olga Tarabal, Alejandro Barranco, Suzette L. Pereira, Anna Casanovas, Guillem Mòdol-Caballero, Sílvia Gras, Jordi Calderó

Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Journal of Cachexia, Sarcopenia and Muscle
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)

Background The cellular mechanisms underlying the age‐associated loss of muscle mass and function (sarcopenia) are poorly understood, hampering the development of effective treatment strategies. Here, we performed a detailed characterization of age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16270221f5c34d1afef30d6c34cee1a6
https://doi.org/10.1002/jcsm.12599

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