Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jorden A. Johnson"'
Publikováno v:
Molecules, Vol 25, Iss 17, p 3949 (2020)
As fragment-based drug discovery has become mainstream, there has been an increase in various screening methodologies. Protein-observed 19F (PrOF) NMR and 1H CPMG NMR are two fragment screening assays that have complementary advantages. Here, we soug
Externí odkaz:
https://doaj.org/article/7a3dc3b4272f40e8a2cdabf9472d7965
Autor:
Huarui Cui, Anand Divakaran, Zachariah J. Hoell, Mikael O. Ellingson, Cole R. Scholtz, Huda Zahid, Jorden A. Johnson, Elizabeth C. Griffith, Clifford T. Gee, Amani L. Lee, Shalil Khanal, Ke Shi, Hideki Aihara, Vijay H. Shah, Richard E. Lee, Daniel A. Harki, William C. K. Pomerantz
Publikováno v:
J Med Chem
Chemical probes for epigenetic proteins are essential tools for dissecting the molecular mechanisms for gene regulation and therapeutic development. The bromodomain and extra-terminal (BET) proteins are master transcriptional regulators. Despite prom
Autor:
Jorden A. Johnson, Siva Kumar Talluri, Peter D. Ycas, A. Chan, William C. K. Pomerantz, Ernst Schönbrunn, Noelle M. Olson, Huda Zahid
Publikováno v:
Org Biomol Chem
Bromodomain-containing proteins regulate transcription through protein-protein interactions with chromatin and serve as scaffolding proteins for recruiting essential members of the transcriptional machinery. One such protein is the bromodomain and PH
Autor:
Christos A. Nicolaou, Haitao Hu, Steven E. Kirberger, Anil K. Pandey, Jorden A. Johnson, William C. K. Pomerantz
Publikováno v:
ACS Med Chem Lett
[Image: see text] Fragment-based ligand discovery has been successful in targeting diverse proteins. Despite drug-like molecules having more 3D character, traditional fragment libraries are largely composed of flat, aromatic fragments. The use of 3D-
Autor:
William C. K. Pomerantz, Huarui Cui, Nora R. Vail, Ke Shi, Anand Divakaran, Jorden A. Johnson, Huda Zahid, Grover P. Miller, Daniel A. Harki, Joseph J. Topczewski, Caroline R. Buchholz, Hideki Aihara, Mary A. Schleiff, Angela S. Carlson
Publikováno v:
J Med Chem
The bromodomain and extra terminal (BET) protein family recognizes acetylated lysines within histones and transcription factors using two N-terminal bromodomains, D1 and D2. The protein–protein interactions between BET bromodomains, acetylated hist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7902ab86e4ce714d58bf51d36986f5
https://europepmc.org/articles/PMC8491147/
https://europepmc.org/articles/PMC8491147/
Autor:
Noelle M. Olson, Jorden A. Johnson, Kerstin E. Peterson, Stephen C. Heinsch, Andrew P. Marshall, Michael J. Smanski, Erin E. Carlson, William C.K. Pomerantz
Publikováno v:
J Fluor Chem
Current experiments that rely on biosynthetic metabolic protein labeling with (19)F often require fluorinated amino acids, which in the case of 2- and 3-fluorotyrosine can be expensive. However, using these amino acids has provided valuable insight i
Publikováno v:
Molecules
Molecules, Vol 25, Iss 3949, p 3949 (2020)
Volume 25
Issue 17
Molecules, Vol 25, Iss 3949, p 3949 (2020)
Volume 25
Issue 17
As fragment-based drug discovery has become mainstream, there has been an increase in various screening methodologies. Protein-observed 19F (PrOF) NMR and 1H CPMG NMR are two fragment screening assays that have complementary advantages. Here, we soug
Autor:
Anand Divakaran, Jorden A. Johnson, Ke Shi, Huarui Cui, Hideki Aihara, Daniel A. Harki, Anil K. Pandey, Mikael O Ellingson, Huda Zahid, William C. K. Pomerantz, Zachariah J Hoell
Publikováno v:
Angew Chem Int Ed Engl
Bromodomain and extra-terminal (BET) family proteins, BRD2-4 and T, are important drug targets; however, the biological functions of each bromodomain remain ill-defined. Chemical probes that selectively inhibit a single BET bromodomain are lacking, a
Autor:
Huarui Cui, Anand Divakaran, Anil K. Pandey, Jorden A. Johnson, huda zahid, zachary hoell, mikael ellingson, ke shi, Hideki Aihara, Daniel A. Harki, william pomerantz
This manuscript focuses on the structure-based design of selective inhibitors of the first bromodomain of BRD4. This manuscript uses describes organic synthesis to make inhibitors, and biophysical analysis to evaluate their inhibitor potency in compe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6977776df1ca078d9f50c57a6f3cfb80
https://doi.org/10.26434/chemrxiv.12156747
https://doi.org/10.26434/chemrxiv.12156747
Autor:
Jennifer R Kimbrough, Jorden A. Johnson, Steven E. Kirberger, Anil K. Pandey, William C. K. Pomerantz, Danika K. D. Partridge
Publikováno v:
Organic Letters. 22:5271-5272