Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jordany R. Maignan"'
Autor:
Andrii Monastyrskyi, Jordany R. Maignan, Fabian Brockmeyer, Ami H. Asakawa, Sherwin Mashkouri, Prakash T. Parvatkar, Debora Casandra, Yingzhao Zhao, Dennis E. Kyle, Lili Huang, Roman Manetsch, Vivian Padín-Irizarry, Steven P. Maher, Alexis N. LaCrue, Yana I Sakhno
Publikováno v:
J Med Chem
Preclinical and clinical development of numerous small molecules is prevented by their poor aqueous solubility, limited absorption, and oral bioavailability. Herein, we disclose a general prodrug approach that converts promising lead compounds into a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005b49dd5345b7c5ef1724b0ef0b7f31
https://europepmc.org/articles/PMC8904075/
https://europepmc.org/articles/PMC8904075/
Autor:
Paul Willis, Sherwin Mashkouri, Roman Manetsch, Alexis N. LaCrue, Jordany R. Maignan, Andrii Monastyrskyi, Debora Casandra, Tina S. Mutka, Cynthia L. Lichorowic, Raghupathi Neelarapu, Dennis E. Kyle, Lynn D. Blake, Jeremy N. Burrows
Publikováno v:
Journal of Medicinal Chemistry. 61:1450-1473
Malaria deaths have been decreasing over the last 10–15 years, with global mortality rates having fallen by 47% since 2000. While the World Health Organization (WHO) recommends the use of artemisinin-based combination therapies (ACTs) to combat mal
Autor:
Karen L. White, David L. Flanigan, Andrii Monastyrskyi, Fabián E. Sáenz, Frank R. Fronczek, Matthew Cross, Dennis E. Kyle, Ian Bathurst, Roman Manetsch, Lukasz Wojtas, Alexis N. LaCrue, David M. Shackleford, Tina S. Mutka, Susan A. Charman, Wayne C. Guida, Jordany R. Maignan, Jeremy N. Burrows
Publikováno v:
Journal of Medicinal Chemistry
The continued proliferation of malaria throughout temperate and tropical regions of the world has promoted a push for more efficacious treatments to combat the disease. Unfortunately, more recent remedies such as artemisinin combination therapies hav
Autor:
R. Matthew Cross, Kenneth O. Udenze, Jordany R. Maignan, Dennis E. Kyle, Fabián E. Sáenz, Roman Manetsch, Alexis N. LaCrue
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:6187-6195
Malaria kills approximately 1 million people a year, mainly in sub-Saharan Africa. Essential steps in the life cycle of the parasite are the development of gametocytes, as well as the formation of oocysts and sporozoites, in the Anopheles mosquito ve
Autor:
Roman Manetsch, Paul Willis, Debora Casandra, James Giarrusso, Dennis E. Kyle, Alexis N. LaCrue, Cynthia L. Lichorowic, Jeremy N. Burrows, Jordany R. Maignan, Tina S. Mutka, Lynn D. Blake
Publikováno v:
J Med Chem
Malaria is estimated to have caused 584,000 deaths and 198 million cases of the disease globally in 2013. Though mortality rates are down 47% globally since 2000 and significant progress has been made in the quest for eradication, reported occurrence
Autor:
Dennis E. Kyle, Jordany R. Maignan, R. Matthew Cross, Tina S. Mutka, Justin Sargent, Roman Manetsch, Lisa Luong
Publikováno v:
Journal of Medicinal Chemistry. 54:4399-4426
Antimalarial activity of 1,2,3,4-tetrahydroacridin-9(10H)-ones (THAs) has been known since the 1940s and has garnered more attention with the development of the acridinedione floxacrine (1) in the 1970s and analogues thereof such as WR 243251 (2a) in