Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Jordan W. Squair"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Differential accessibility (DA) analysis of single-cell epigenomics data enables the discovery of regulatory programs that establish cell type identity and steer responses to physiological and pathophysiological perturbations. While many sta
Externí odkaz:
https://doaj.org/article/793d4834872a4dac9d9bba82d4a07595
Autor:
Kaya J. E. Matson, Daniel E. Russ, Claudia Kathe, Isabelle Hua, Dragan Maric, Yi Ding, Jonathan Krynitsky, Randall Pursley, Anupama Sathyamurthy, Jordan W. Squair, Boaz P. Levi, Gregoire Courtine, Ariel J. Levine
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Matson et al. performed single nucleus sequencing of the “spared” spinal cord tissue distal to an injury in mice. They found that spinocerebellar neurons expressed a pro-regenerative gene signature and showed axon outgrowth after injury.
Externí odkaz:
https://doaj.org/article/cf00edd9055f4674b40f954fa5095d19
Autor:
Jan Elaine Soriano, Jordan W. Squair, Jacquelyn J. Cragg, Jennifer Thompson, Rafael Sanguinetti, Bita Vaseghi, Carolyn A. Emery, Christopher Grant, Rebecca Charbonneau, Kelly A. Larkin-Kaiser, Aaron A. Phillips, Zeljko Dujic
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Physical activity is a powerful modifiable risk factor for disease and mortality. Physical activity levels in people with spinal cord injury (SCI) have not been quantified relative to uninjured individuals in a large population-based sample.
Externí odkaz:
https://doaj.org/article/0b99461aeff34122a74e54916dd4d270
Autor:
Mary P. M. Fossey, Shane J. T. Balthazaar, Jordan W. Squair, Alexandra M. Williams, Malihe-Sadat Poormasjedi-Meibod, Tom E. Nightingale, Erin Erskine, Brian Hayes, Mehdi Ahmadian, Garett S. Jackson, Diana V. Hunter, Katharine D. Currie, Teresa S. M. Tsang, Matthias Walter, Jonathan P. Little, Matt S. Ramer, Andrei V. Krassioukov, Christopher R. West
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
By combining experimental models with prospective clinical studies, the authors show that spinal cord injury causes a rapid reduction in cardiac function that precedes structural changes, and that the loss of descending sympathetic control is the maj
Externí odkaz:
https://doaj.org/article/3046aebaccdc45cdbfc10db7ef4000cf
Autor:
Jordan W. Squair, Matthieu Gautier, Claudia Kathe, Mark A. Anderson, Nicholas D. James, Thomas H. Hutson, Rémi Hudelle, Taha Qaiser, Kaya J. E. Matson, Quentin Barraud, Ariel J. Levine, Gioele La Manno, Michael A. Skinnider, Grégoire Courtine
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries
Externí odkaz:
https://doaj.org/article/315bac3c84574451adbbba4a10948a12
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-5 (2021)
Externí odkaz:
https://doaj.org/article/38977cc431d54667ade597591dc02880
Autor:
Marco Bonizzato, Nicholas D. James, Galyna Pidpruzhnykova, Natalia Pavlova, Polina Shkorbatova, Laetitia Baud, Cristina Martinez-Gonzalez, Jordan W. Squair, Jack DiGiovanna, Quentin Barraud, Silvestro Micera, Gregoire Courtine
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Deep brain stimulation and epidural electrical stimulation of the spinal cord enable locomotion in humans with spinal cord injury (SCI) but the potential synergy between both approaches is unclear. The authors show that a complex technological approa
Externí odkaz:
https://doaj.org/article/3e33fdf15f7148f6ac0e70238e049c1c
Autor:
Kathryn A. Harman, Kathryn M. DeVeau, Jordan W. Squair, Christopher R. West, Andrei V. Krassioukov, David S. K. Magnuson
Publikováno v:
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Abstract Hemodynamic instability and cardiovascular (CV) dysfunction are hallmarks of patients living with cervical and high thoracic spinal cord injuries (SCI). Individuals experience bouts of autonomic dysreflexia (AD) and persistent hypotension wh
Externí odkaz:
https://doaj.org/article/2a8e68c1434a4b2797e3bbb7b6e02365
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Astrocytes are essential for the development and homeostatic maintenance of the central nervous system (CNS). They are also critical players in the CNS injury response during which they undergo a process referred to as “reactive astrogliosis.” Di
Externí odkaz:
https://doaj.org/article/3159265feb344db482e6ac1b259efca0
Publikováno v:
Bioelectronic Medicine, Vol 5, Iss 1, Pp 1-19 (2019)
Abstract In the absence of approved treatments to repair damage to the central nervous system, the role of neurosurgeons after spinal cord injury (SCI) often remains confined to spinal cord decompression and vertebral fracture stabilization. However,
Externí odkaz:
https://doaj.org/article/6ceecfa2bf414c25b296bdcb03139db9