Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jordan T. Newington"'
Autor:
Jordan T Newington, Andrea Pitts, Andrew Chien, Robert Arseneault, David Schubert, Robert C Cumming
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19191 (2011)
Amyloid beta (Aβ) peptide accumulation in the brains of patients with Alzheimer's disease (AD) is closely associated with increased nerve cell death. However, many cells survive and it is important to understand the mechanisms involved in this survi
Externí odkaz:
https://doaj.org/article/65ba085fc0ea441281202ff85aa0d6b0
Autor:
Robert C. Cumming, Andrew Chien, Robert Arseneault, Richard A. Harris, Tim Rappon, Jordan T. Newington
Publikováno v:
Cancer Letters. 338:255-266
Aerobic glycolysis, the preferential use of glycolysis even in the presence of oxygen to meet cellular metabolic demands, is a near universal feature of cancer. This unique type of metabolism is thought to protect cancer cells from damaging reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30a583bd729910600e7a9e37a21d6c6
https://doi.org/10.1016/j.canlet.2013.03.034
https://doi.org/10.1016/j.canlet.2013.03.034
Publikováno v:
Journal of Neurodegenerative Diseases
The conventional view of central nervous system (CNS) metabolism is based on the assumption that glucose is the main fuel source for active neurons and is processed in an oxidative manner. However, since the early 1990s research has challenged the id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8cb1551f2534802eed2d94babe8450
https://pubmed.ncbi.nlm.nih.gov/26316984
https://pubmed.ncbi.nlm.nih.gov/26316984
Autor:
Jordan T. Newington, Daisy Y. Wong, Robert C. Cumming, Tim Rappon, R. Jane Rylett, Shawn Albers
Publikováno v:
Paediatrics Publications
We previously demonstrated that nerve cell lines selected for resistance to amyloid β (Aβ) peptide exhibit elevated aerobic glycolysis in part due to increased expression of pyruvate dehydrogenase kinase 1 (PDK1) and lactate dehydrogenase A (LDHA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7c4b36208d0c819e182a8162084dba
https://ir.lib.uwo.ca/context/paedpub/article/2021/viewcontent/PIIS0021925820625236.pdf
https://ir.lib.uwo.ca/context/paedpub/article/2021/viewcontent/PIIS0021925820625236.pdf
Publikováno v:
Alzheimer's & Dementia. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c875ca5f04ad3c8055bd516c9c32a785
https://doi.org/10.1016/j.jalz.2012.05.836
https://doi.org/10.1016/j.jalz.2012.05.836
Autor:
Jordan T. Newington, Tyler Cann, Kyle Dailey, Andrew Chien, Robert C. Cumming, Robert Arseneault, Andrea Pitts, Leslie M. Thompson
Publikováno v:
Paediatrics Publications
Mitochondrial dysfunction and elevated reactive oxygen species are strongly implicated in both aging and various neurodegenerative disorders, including Huntington disease (HD). Because reactive oxygen species can promote the selective oxidation of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2de50e3ec19ec8546dce29640e7a0e
https://ir.lib.uwo.ca/context/paedpub/article/2022/viewcontent/22717.full.pdf
https://ir.lib.uwo.ca/context/paedpub/article/2022/viewcontent/22717.full.pdf