Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jordan T. Gladman"'
Autor:
Aishwarya G. Jacob, Dennis O'Brien, Ravi K. Singh, Daniel F. Comiskey, Jr, Robert M. Littleton, Fuad Mohammad, Jordan T. Gladman, Maria C. Widmann, Selvi C. Jeyaraj, Cheryl Bolinger, James R. Anderson, Donald A. Barkauskas, Kathleen Boris-Lawrie, Dawn S. Chandler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 9, Pp 1049-1063 (2013)
Pediatric rhabdomyosarcoma (RMS) is a morphologically and genetically heterogeneous malignancy commonly classified into three histologic subtypes, namely, alveolar, embryonal, and anaplastic. An issue that continues to challenge effective RMS patient
Externí odkaz:
https://doaj.org/article/53b97b11b81b4eb4aafcf498a7dac607
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0150192 (2016)
Myotonic dystrophy type 1 (DM1), the most common form of muscular dystrophy in adults, is caused by toxic RNAs produced from the mutant DM protein kinase (DMPK) gene. DM1 is characterized by progressive muscle wasting and weakness. Therapeutic strate
Externí odkaz:
https://doaj.org/article/da8d9ca5a0f248d4b35c01403e596705
Autor:
Karunasai Mahadevan, Mani S. Mahadevan, Yun K. Kim, Mahua Mandal, Qing Yu, Jordan T. Gladman, Ramesh S. Yadava
Publikováno v:
Hum Mol Genet
Myotonic dystrophy type 1 (DM1) is caused by an expanded (CTG)n tract in the 3′UTR of the DM protein kinase (DMPK) gene. The RNA transcripts produced from the expanded allele sequester or alter the function of RNA-binding proteins (MBNL1, CUGBP1, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12431120710d8c4b0eae353f5294af92
https://doi.org/10.1093/hmg/ddz065
https://doi.org/10.1093/hmg/ddz065
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95957 (2014)
Förster Resonance Energy Transfer (FRET) microscopy is a powerful tool used to identify molecular interactions in live or fixed cells using a non-radiative transfer of energy from a donor fluorophore in the excited state to an acceptor fluorophore i
Externí odkaz:
https://doaj.org/article/7e901708c1354b9cb661accacd7b638f
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72907 (2013)
Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults. It is caused by an expanded (CTG)n tract in the 3' UTR of the Dystrophia Myotonica Protein Kinase (DMPK) gene. This causes nuclear retention of the mutant mRNA into ribo
Externí odkaz:
https://doaj.org/article/349c1d91ca3d4712ae019868bcdaf489
Autor:
Martin Dichgans, Steven M. Greenberg, Stéphanie Debette, Jordan T. Gladman, Perminder S. Sachdev, Roderick A. Corriveau, Joanna M. Wardlaw, Geert Jan Biessels
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Gladman, J T, Corriveau, R A, Debette, S, Dichgans, M, Greenberg, S M, Sachdev, P S, Wardlaw, J M & Biessels, G J 2019, ' Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide ', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 5, no. C, pp. 789-796 . https://doi.org/10.1016/j.trci.2019.09.017
Edinburgh Research Explorer
PubMed Central
Alzheimer's and Dementia: Translational Research and Clinical Interventions, 5, 789. Elsevier Inc.
Alzheimer's & Dementia: Translational Research & Clinical Interventions
Alzheimer's & Dementia: Translational Research & Clinical Interventions, Elsevier, 2019, 5, pp.789-796. ⟨10.1016/j.trci.2019.09.017⟩
Alzheimer's & dementia / Translational research & clinical interventions 5(1), 789-796 (2019). doi:10.1016/j.trci.2019.09.017
Alzheimers & Dementia: Translational Research & Clinical Interventions
Gladman, J T, Corriveau, R A, Debette, S, Dichgans, M, Greenberg, S M, Sachdev, P S, Wardlaw, J M & Biessels, G J 2019, ' Vascular contributions to cognitive impairment and dementia: Research consortia that focus on etiology and treatable targets to lessen the burden of dementia worldwide ', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 5, no. C, pp. 789-796 . https://doi.org/10.1016/j.trci.2019.09.017
Edinburgh Research Explorer
PubMed Central
Alzheimer's and Dementia: Translational Research and Clinical Interventions, 5, 789. Elsevier Inc.
Alzheimer's & Dementia: Translational Research & Clinical Interventions
Alzheimer's & Dementia: Translational Research & Clinical Interventions, Elsevier, 2019, 5, pp.789-796. ⟨10.1016/j.trci.2019.09.017⟩
Alzheimer's & dementia / Translational research & clinical interventions 5(1), 789-796 (2019). doi:10.1016/j.trci.2019.09.017
Alzheimers & Dementia: Translational Research & Clinical Interventions
The research into vascular contributions to cognitive impairment and dementia (VCID) aims to understand the importance of cerebrovascular biology in cognitive decline. Prevention and treatment of VCID is poised to have major impact on dementia-relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c064ff0315c4f8c267f8efe0e4fc40
http://hdl.handle.net/20.500.12278/8079
http://hdl.handle.net/20.500.12278/8079
Autor:
Francesca Bosetti, Roderick A. Corriveau, Katherine Pahigiannis, Marian Emr, James I. Koenig, Salina P. Waddy, Walter J. Koroshetz, Claudia S. Moy, Jordan T. Gladman
Publikováno v:
Cellular and Molecular Neurobiology. 36:281-288
The World Health Organization reports that 47.5 million people are affected by dementia worldwide. With aging populations and 7.7 million new cases each year, the burden of illness due to dementia approaches crisis proportions. Despite significant ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ec4e30b292ac64e634269d426d67a8
https://doi.org/10.1007/s10571-016-0334-7
https://doi.org/10.1007/s10571-016-0334-7
Autor:
Yun K. Kim, Qing Yu, Mani S. Mahadevan, Jordan T. Gladman, Kirti Bhatt, Timothy S. Zheng, Charles A. Thornton, Erin P. Foff, Ramesh S. Yadava
Publikováno v:
Human Molecular Genetics. 24:2035-2048
Myotonic dystrophy type 1 (DM1), the most prevalent muscular dystrophy in adults, is characterized by progressive muscle wasting and multi-systemic complications. DM1 is the prototype for disorders caused by RNA toxicity. Currently, no therapies exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a99bc0f1c62db2d41bd732113360785
https://doi.org/10.1093/hmg/ddu617
https://doi.org/10.1093/hmg/ddu617
Autor:
Margaret Sutherland, Susan Dickinson, Jennifer J. Manly, William W. Seeley, Marian Emr, Steven M. Greenberg, Creighton H. Phelps, David M. Holtzman, Debra Babcock, Nina Silverberg, Claudia S. Moy, Angela C. Taylor, Christine L. Torborg, Beth Anne Sieber, Sophia Jeon, David A. Bennett, S. Thomas Carmichael, Salina P. Waddy, P. Scott, Dennis W. Dickson, Jordan T. Gladman, Walter J. Koroshetz, Karen Marder, Amelie K. Gubitz, David S. Knopman, Roderick A. Corriveau, Howard Fillit, Michael Hutton
Publikováno v:
Neurology, vol 89, iss 23
Goal 1 of the National Plan to Address Alzheimer’s Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease–related dementias by 2025. To help inform the research agenda toward achieving this goal, the NIH hosts periodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cc4988596a0cc65377cd272ab06245
https://pubmed.ncbi.nlm.nih.gov/29117955
https://pubmed.ncbi.nlm.nih.gov/29117955
Publikováno v:
Human Molecular Genetics. 24:251-264
RNA toxicity is implicated in a number of disorders; especially those associated with expanded repeat sequences, such as myotonic dystrophy (DM1). Previously, we have shown increased NKX2-5 expression in RNA toxicity associated with DM1. Here, we inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71be9abe32432518e65fa98bdef21425
https://doi.org/10.1093/hmg/ddu443
https://doi.org/10.1093/hmg/ddu443