Zobrazeno 1 - 10
of 409
pro vyhledávání: '"Jordan S, Pober"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Serum response factor (SRF) controls gene transcription in vascular smooth muscle cells (VSMCs) and regulates VSMC phenotypic switch from a contractile to a synthetic state, which plays a key role in the pathogenesis of cardiovascular diseas
Externí odkaz:
https://doaj.org/article/8e2772b1af744a1ab833e117a481cac3
Autor:
Alexandra S. Piotrowski-Daspit, Laura G. Bracaglia, David A. Eaton, Owen Richfield, Thomas C. Binns, Claire Albert, Jared Gould, Ryland D. Mortlock, Marie E. Egan, Jordan S. Pober, W. Mark Saltzman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The in vivo efficacy of polymeric nanoparticles (NPs) is dependent on their pharmacokinetics, including time in circulation and tissue tropism. Here we explore the structure-function relationships guiding physiological fate of a library of p
Externí odkaz:
https://doaj.org/article/1fd79750bbb044449ad583ead8cb54cf
Autor:
Xue Li, Quan Jiang, Guiyu Song, Mahsa Nouri Barkestani, Qianxun Wang, Shaoxun Wang, Matthew Fan, Caodi Fang, Bo Jiang, Justin Johnson, Arnar Geirsson, George Tellides, Jordan S. Pober, Dan Jane-wit
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Internalization of complement membrane attack complexes (MACs) assembles NLRP3 inflammasomes in endothelial cells (EC) and promotes IL-β-mediated tissue inflammation. Informed by proteomics analyses of FACS-sorted inflammasomes, we identify
Externí odkaz:
https://doaj.org/article/73d4be8bbed044429f60bcc1d5d0dca6
Autor:
Zeguo Sun, Zhongyang Zhang, Khadija Banu, Ian W. Gibson, Robert B. Colvin, Zhengzi Yi, Weijia Zhang, Bony De Kumar, Anand Reghuvaran, John Pell, Thomas D. Manes, Arjang Djamali, Lorenzo Gallon, Philip J. O’Connell, John Cijiang He, Jordan S. Pober, Peter S. Heeger, Madhav C. Menon
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Donor-recipient (D-R) mismatches outside of human leukocyte antigens (HLAs) contribute to kidney allograft loss, but the mechanisms remain unclear, specifically for intronic mismatches. We quantified non-HLA mismatches at variant-, gene-, and genome-
Externí odkaz:
https://doaj.org/article/1062a57a1df84d2eb0cec1a6f8b62c10
Autor:
Shaoxun Wang, Guiyu Song, Mahsa Nouri Barkestani, Zuzana Tobiasova, Qianxun Wang, Quan Jiang, Roberto Lopez, Yasmin Adelekan-Kamara, Matthew Fan, Jordan S. Pober, George Tellides, Dan Jane-wit
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionIschemia reperfusion injury (IRI) confers worsened outcomes and is an increasing clinical problem in solid organ transplantation. Previously, we identified a “PtchHi” T-cell subset that selectively received costimulatory signals from
Externí odkaz:
https://doaj.org/article/4ca01d1d88114534882289e450ed8b40
Autor:
Asawari Korde, Maria Haslip, Prachi Pednekar, Alamzeb Khan, Maurizio Chioccioli, Sameet Mehta, Francesc Lopez-Giraldez, Santos Bermejo, Mauricio Rojas, Charles Dela Cruz, Michael A. Matthay, Jordan S. Pober, Richard W. Pierce, Shervin S. Takyar
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), cause severe endothelial dysfunction in the lung, and vascular endothelial growth factor (VEGF) is elevated in ARDS. We found that the levels of a VEGF-regu
Externí odkaz:
https://doaj.org/article/ebda4adf73f34110a81a0dc129c0b9de
Autor:
Dennis G. Moledina, Wassim Obeid, Rex N. Smith, Ivy Rosales, Meghan E. Sise, Gilbert Moeckel, Michael Kashgarian, Michael Kuperman, Kirk N. Campbell, Sean Lefferts, Kristin Meliambro, Markus Bitzer, Mark A. Perazella, Randy L. Luciano, Jordan S. Pober, Lloyd G. Cantley, Robert B. Colvin, F. Perry Wilson, Chirag R. Parikh
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Background Acute tubulointerstitial nephritis (AIN) is one of the few causes of acute kidney injury with diagnosis-specific treatment options. However, due to the need to obtain a kidney biopsy for histological confirmation, AIN diagnosis can be dela
Externí odkaz:
https://doaj.org/article/8efe2f2685704f25a2ece87934b2792f
Autor:
Adi Egozi, Oluwabunmi Olaloye, Lael Werner, Tatiana Silva, Blake McCourt, Richard W Pierce, Xiaojing An, Fujing Wang, Kong Chen, Jordan S Pober, Dror Shouval, Shalev Itzkovitz, Liza Konnikova
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3002124 (2023)
Necrotizing enterocolitis (NEC) is a gastrointestinal complication of premature infants with high rates of morbidity and mortality. A comprehensive view of the cellular changes and aberrant interactions that underlie NEC is lacking. This study aimed
Externí odkaz:
https://doaj.org/article/9b1581b62447470ea9e8a8526e8a60d5
Autor:
Xue Li, Quan Jiang, Guiyu Song, Mahsa Nouri Barkestani, Qianxun Wang, Shaoxun Wang, Matthew Fan, Caodi Fang, Bo Jiang, Justin Johnson, Arnar Geirsson, George Tellides, Jordan S. Pober, Dan Jane-wit
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/787081c29d7e4b8bb572acf783f37322
Autor:
Tania Baltazar, Bo Jiang, Alejandra Moncayo, Jonathan Merola, Mohammad Z. Albanna, W. Mark Saltzman, Jordan S. Pober
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)
Abstract Bioengineered tissues or organs produced using matrix proteins or components derived from xenogeneic sources pose risks of allergic responses, immune rejection, or even autoimmunity. Here, we report successful xeno‐free isolation, expansio
Externí odkaz:
https://doaj.org/article/cca95b821139495c9811f7522656e8f0