Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jordan R. Willis"'
Autor:
Allan C. deCamp, Martin M. Corcoran, William J. Fulp, Jordan R. Willis, Christopher A. Cottrell, Daniel L. V. Bader, Oleksandr Kalyuzhniy, David J. Leggat, Kristen W. Cohen, Ollivier Hyrien, Sergey Menis, Greg Finak, Lamar Ballweber-Fleming, Abhinaya Srikanth, Jason R. Plyler, Farhad Rahaman, Angela Lombardo, Vincent Philiponis, Rachael E. Whaley, Aaron Seese, Joshua Brand, Alexis M. Ruppel, Wesley Hoyland, Celia R. Mahoney, Alberto Cagigi, Alison Taylor, David M. Brown, David R. Ambrozak, Troy Sincomb, Tina-Marie Mullen, Janine Maenza, Orpheus Kolokythas, Nadia Khati, Jeffrey Bethony, Mario Roederer, David Diemert, Richard A. Koup, Dagna S. Laufer, Juliana M. McElrath, Adrian B. McDermott, Gunilla B. Karlsson Hedestam, William R. Schief
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Vaccine priming immunogens that activate germline precursors for broadly neutralizing antibodies (bnAbs) have promise for development of precision vaccines against major human pathogens. In a clinical trial of the eOD-GT8 60mer germline-targ
Externí odkaz:
https://doaj.org/article/2e580eabca0b4c0f8e97acb243086a89
Autor:
Cinque Soto, Jessica A. Finn, Jordan R. Willis, Samuel B. Day, Robert S. Sinkovits, Taylor Jones, Samuel Schmitz, Jens Meiler, Andre Branchizio, James E. Crowe
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background Recent advances in DNA sequencing technologies have enabled significant leaps in capacity to generate large volumes of DNA sequence data, which has spurred a rapid growth in the use of bioinformatics as a means of interrogating an
Externí odkaz:
https://doaj.org/article/edd5c95dc07b4be798f44bcf7e346469
Autor:
Tom Z. Yuan, Pankaj Garg, Linya Wang, Jordan R. Willis, Eric Kwan, Ana G Lujan Hernandez, Emily Tuscano, Emily N. Sever, Erica Keane, Cinque Soto, Eric M. Mucker, Mallorie E. Fouch, Edgar Davidson, Benjamin J. Doranz, Shweta Kailasan, M. Javad Aman, Haoyang Li, Jay W. Hooper, Erica Ollmann Saphire, James E. Crowe, Qiang Liu, Fumiko Axelrod, Aaron K. Sato
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Coronavirus disease 2019 (COVID-19) is an evolving global public health crisis in need of therapeutic options. Passive immunization of monoclonal antibodies (mAbs) represents a promising therapeutic strategy capable of conferring immediate protection
Externí odkaz:
https://doaj.org/article/b6c1901170674ee7807acd867a09110b
Autor:
Daniel W. Kulp, Jon M. Steichen, Matthias Pauthner, Xiaozhen Hu, Torben Schiffner, Alessia Liguori, Christopher A. Cottrell, Colin Havenar-Daughton, Gabriel Ozorowski, Erik Georgeson, Oleksandr Kalyuzhniy, Jordan R. Willis, Michael Kubitz, Yumiko Adachi, Samantha M. Reiss, Mia Shin, Natalia de Val, Andrew B. Ward, Shane Crotty, Dennis R. Burton, William R. Schief
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Eliciting broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal, but available immunogens expose epitopes for development of non-nAbs. Here, the authors use computational and structure-guided design to develop improved native-like env
Externí odkaz:
https://doaj.org/article/e45b30de0325403bb21de6e2ce224daa
Autor:
Morgan L. Nance, Steven J. Bertolani, William R. Schief, Rebecca F. Alford, Daniel W. Kulp, Jason C. Klima, Shourya S. Roy Burman, Yuanhan Wu, Jack Maguire, Jordan R. Willis, Roland L. Dunbrack, Andrew Leaver-Fay, Jason W. Labonte, Aleexsan Adal, Ramya Rangan, Brian Kuhlman, Sergey Lyskov, Jared Adolf-Bryfogle, Justin B. Siegel, Kathy H. Le, Rhiju Das, Jeffrey J. Gray, Brian D. Weitzner, Matt A. Adrianowycz
Publikováno v:
Biophysicist (Rockv)
Biomolecular structure drives function, and computational capabilities have progressed such that the prediction and computational design of biomolecular structures is increasingly feasible. Because computational biophysics attracts students from many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb58dd22c2bb7028a8c98596909a46ca
https://doi.org/10.35459/tbp.2019.000147
https://doi.org/10.35459/tbp.2019.000147
Autor:
Jessica A Finn, Julia Koehler Leman, Jordan R Willis, Alberto Cisneros, James E Crowe, Jens Meiler
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154811 (2016)
Structural restrictions are present even in the most sequence diverse portions of antibodies, the complementary determining region (CDR) loops. Previous studies identified robust rules that define canonical structures for five of the six CDR loops, h
Externí odkaz:
https://doaj.org/article/95d9151e4e9d4a5c86ca3df27dbc6d1c
Autor:
Eleonora Melzi, Jordan R. Willis, Krystal M. Ma, Ying-Cing Lin, Sven Kratochvil, Zachary T. Berndsen, Elise A. Landais, Oleksandr Kalyuzhniy, Usha Nair, John Warner, Jon M. Steichen, Anton Kalyuzhniy, Amber Le, Simone Pecetta, Manfredo Perez, Kathrin Kirsch, Stephanie R. Weldon, Samantha Falcone, Sunny Himansu, Andrea Carfi, Devin Sok, Andrew B. Ward, William R. Schief, Facundo D. Batista
Publikováno v:
Immunity. 55(11)
Eliciting broadly neutralizing antibodies (bnAbs) is the core of HIV vaccine design. bnAbs specific to the V2-apex region of the HIV envelope acquire breadth and potency with modest somatic hypermutation, making them attractive vaccination targets. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd499a4a96174a0c3d0ed4c1e6155698
https://pubmed.ncbi.nlm.nih.gov/36179690
https://pubmed.ncbi.nlm.nih.gov/36179690
Autor:
Jordan R. Willis, Zachary T. Berndsen, Krystal M. Ma, Jon M. Steichen, Torben Schiffner, Elise Landais, Alessia Liguori, Oleksandr Kalyuzhniy, Joel D. Allen, Sabyasachi Baboo, Oluwarotimi Omorodion, Jolene K. Diedrich, Xiaozhen Hu, Erik Georgeson, Nicole Phelps, Saman Eskandarzadeh, Bettina Groschel, Michael Kubitz, Yumiko Adachi, Tina-Marie Mullin, Nushin B. Alavi, Samantha Falcone, Sunny Himansu, Andrea Carfi, Ian A. Wilson, John R. Yates, James C. Paulson, Max Crispin, Andrew B. Ward, William R. Schief
Publikováno v:
Immunity. 55(11)
Broadly neutralizing antibodies (bnAbs) to the HIV envelope (Env) V2-apex region are important leads for HIV vaccine design. Most V2-apex bnAbs engage Env with an uncommonly long heavy-chain complementarity-determining region 3 (HCDR3), suggesting th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7039e0eead4b1fcdc1dd22908c1c84
https://pubmed.ncbi.nlm.nih.gov/36179689
https://pubmed.ncbi.nlm.nih.gov/36179689
Autor:
Tom Z. Yuan, Pankaj Garg, Linya Wang, Jordan R. Willis, Eric Kwan, Ana G Lujan Hernandez, Emily Tuscano, Emily N. Sever, Erica Keane, Cinque Soto, Eric M. Mucker, Mallorie E. Fouch, Edgar Davidson, Benjamin J. Doranz, Shweta Kailasan, M. Javad Aman, Haoyang Li, Jay W. Hooper, Erica Ollmann Saphire, James E. Crowe, Qiang Liu, Fumiko Axelrod, Aaron K. Sato
Publikováno v:
mAbs
article-version (VoR) Version of Record
mAbs, Vol 14, Iss 1 (2022)
article-version (VoR) Version of Record
mAbs, Vol 14, Iss 1 (2022)
Coronavirus disease 2019 (COVID-19) is an evolving global public health crisis in need of therapeutic options. Passive immunization of monoclonal antibodies (mAbs) represents a promising therapeutic strategy capable of conferring immediate protection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01454b5bcdde59a32f20af4ed44d29d1
http://europepmc.org/articles/PMC8726723
http://europepmc.org/articles/PMC8726723
Autor:
James E. Crowe, Taylor Jones, Jessica A. Finn, Jens Meiler, Robert S. Sinkovits, Cinque Soto, Jordan R. Willis, Samuel Schmitz, Samuel Day, Andre Branchizio
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-7 (2020)
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-7 (2020)
Background Recent advances in DNA sequencing technologies have enabled significant leaps in capacity to generate large volumes of DNA sequence data, which has spurred a rapid growth in the use of bioinformatics as a means of interrogating antibody va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af85a8fca832a58bad9c6779c961ed9
http://europepmc.org/articles/PMC7364545
http://europepmc.org/articles/PMC7364545