Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jordan M. Hotz"'
Autor:
Robert W. Robey, Andrea N. Robinson, Fatima Ali-Rahmani, Lyn M. Huff, Sabrina Lusvarghi, Shahrooz Vahedi, Jordan M. Hotz, Andrew C. Warner, Donna Butcher, Jennifer Matta, Elijah F. Edmondson, Tobie D. Lee, Jacob S. Roth, Olivia W. Lee, Min Shen, Kandice Tanner, Matthew D. Hall, Suresh V. Ambudkar, Michael M. Gottesman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Capillary endothelial cells of the human blood–brain barrier (BBB) express high levels of P-glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2). However, little information is available regarding ATP-binding cassette transpo
Externí odkaz:
https://doaj.org/article/d695e11725554b04bae4d6fdca65d5b1
Autor:
Ruchi P. Patel, Skyler Kuhn, Da Yin, Jordan M. Hotz, Frances A. Maher, Robert W. Robey, Michael M. Gottesman, Sachi Horibata
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100917- (2021)
Although the first line of therapy for epithelial ovarian cancer typically consists of taxane-platinum combination therapy, many patients develop a platinum-resistant tumor within a year. Several previous studies have looked at this cross-resistance
Externí odkaz:
https://doaj.org/article/33dded77f70e4fac8056743ce6baa44e
Autor:
Brian Buckley, Keith R. Cooper, Kristin R Terez, Jordan M. Hotz, Leonor Côrte-Real, Victoria L. DiBona, Andreia Valente, Brittany F Karas, Brian M Gural
Publikováno v:
Toxicol Sci
Ruthenium is popular as a metal core for chemotherapeutics, due to versatile molecular coordination. Because new metallodrugs are synthesized at high rates, our studies included assays in zebrafish to expedite the initial evaluation as anticancer age
Autor:
Min Shen, Donna Butcher, Olivia W. Lee, Robert W. Robey, Elijah F. Edmondson, Kandice Tanner, Jacob S. Roth, Matthew D. Hall, Andrea N. Robinson, Tobie D. Lee, Michael M. Gottesman, Fatima Ali-Rahmani, Jennifer L Matta, Shahrooz Vahedi, Sabrina Lusvarghi, Jordan M. Hotz, Suresh V. Ambudkar, Lyn M. Huff, Andrew C. Warner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Given its similarities with mammalian systems, the zebrafish has emerged as a potential model to study the blood-brain barrier (BBB). Capillary endothelial cells at the human BBB express high levels of P-glycoprotein (P-gp, encoded by the ABCB1 gene)
Autor:
Jordan M, Hotz, Joanna R, Thomas, Emily N, Katz, Robert W, Robey, Sachi, Horibata, Michael M, Gottesman
Publikováno v:
Cancer drug resistance (Alhambra, Calif.)
The brain is protected from toxins by a tightly regulated network of specialized cells, including endothelial cells, pericytes, astrocyes, and neurons, known collectively as the blood-brain barrier (BBB). This selectively permeable barrier permits on
Autor:
Robert W. Robey, Sachi Horibata, Emily N. Katz, Jordan M. Hotz, Michael M. Gottesman, Joanna R. Thomas
Publikováno v:
Cancer Drug Resistance.
The brain is protected from toxins by a tightly regulated network of specialized cells, including endothelial cells, pericytes, astrocyes, and neurons, known collectively as the blood-brain barrier (BBB). This selectively permeable barrier permits on
Autor:
Skyler Kuhn, Michael M Gottesman, Frances Maher, Da Yin, Robert W. Robey, Jordan M. Hotz, Sachi Horibata, Ruchi P. Patel
Publikováno v:
Translational Oncology
Translational Oncology, Vol 14, Iss 1, Pp 100917-(2021)
Translational Oncology, Vol 14, Iss 1, Pp 100917-(2021)
Highlights • Subpopulations of cisplatin-resistant cells are cross-resistant to anti-microtubule drugs. • Resistance mechanisms in cisplatin-resistant ovarian cancer cells are diverse. • Increased TNF and NFκB signaling found in cisplatin-resi
Publikováno v:
Aquat Toxicol
Zebrafish have gained popularity as a model organism due to their rapid, external, and transparent development, high fecundity, and gene homology with higher vertebrate models and humans. Specifically, drug discovery has had high success in the imple