Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jordan M. Baumhardt"'
Autor:
Yoonji Lee, Yuh Min Chook, Rosa Lapalombella, Binita Shakya, Chad A. Brautigam, Nick V. Grishin, Jordan M. Baumhardt, Janek S. Walker
Publikováno v:
Molecular Biology of the Cell
The E571K mutation of CRM1 is highly prevalent in some cancers, but its mechanism of tumorigenesis is unclear. Glu571 of CRM1 is located in its nuclear export signal (NES)-binding groove, suggesting that binding of select NESs may be altered. We gene
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Nuclear export signal (NES) motifs function as essential regulators of the subcellular location of proteins by interacting with the major nuclear exporter protein, CRM1. Prediction of NES is of great interest in many aspects of research including can
Autor:
Zachary A. Hing, Jennifer A. Woyach, Katie Williams, Kerry A. Rogers, Brian Giacopelli, Neil E. Kay, Jordan M. Baumhardt, Matthew K. Summers, Benjamin R. Stromberg, Sameer A. Parikh, Sharon Shacham, Janek S. Walker, Christopher C. Oakes, Rosa Lapalombella, Vincenzo Coppola, Thomas J. Kipps, Qingxiang Sun, Bonnie K. Harrington, Hatice Gulcin Ozer, Larry Beaver, Laura Z. Rassenti, Amy Lehman, Jordan N. Skinner, Yuh Min Chook, Casey Cempre, Lynne V. Abruzzo, John C. Byrd
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-21 (2021)
Journal of hematology & oncology, vol 14, iss 1
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-21 (2021)
Journal of hematology & oncology, vol 14, iss 1
BackgroundExportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome sequencing has identified hot-spot somaticXPO1point mutations which we found to disrupt
Publikováno v:
Molecular Biology of the Cell
CRM1 (Exportin1/XPO1) exports hundreds of broadly functioning protein cargoes out of the cell nucleus by binding to their classical nuclear export signals (NESs). The 8- to 15-amino-acid-long NESs contain four to five hydrophobic residues and are hig
Publikováno v:
Bioinformatics
Motivation The consensus pattern of Nuclear Export Signal (NES) is a short sequence motif that is commonly identified in protein sequences, whether the motif acts as an NES (true positive) or not (false positive). Finding more plausible NES functioni
Autor:
Daniel J. Saltzberg, Seung Joong Kim, William B. Peeples, Rustam Ali, Michael M. Soniat, Jenny Jiou, Yuan Lin, Andrej Sali, Nicolas L. Fawzi, Michael K. Rosen, Yuh Min Chook, Ho Yee Joyce Fung, Takuya Yoshizawa, Rudolf Oldenbourg, Jordan M. Baumhardt, Kathleen A. Burke
Publikováno v:
Cell, vol 173, iss 3
Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular condensates, cellular compartments that concentrate macromolecules without surrounding membranes. Physical mechanisms that control condensate formation/dissolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37b68163c846ed834bc6d8d66f139be
https://escholarship.org/uc/item/721888cp
https://escholarship.org/uc/item/721888cp
Autor:
Jordan M. Baumhardt, Yuh Min Chook
Publikováno v:
Nucleic Acids and Molecular Biology ISBN: 9783319773087
The karyopherin-β (Kap) family of nuclear transport receptors mediates the majority of nuclear-cytoplasmic transport of macromolecules, especially that of proteins. Kaps include importins that transport cargos into the nucleus, exportins that transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71742952749784d4639edf29f312e028
https://doi.org/10.1007/978-3-319-77309-4_6
https://doi.org/10.1007/978-3-319-77309-4_6
Publikováno v:
Current Enzyme Inhibition
Using wheat germ acid phosphatase and sodium orthovanadate as a competitive inhibitor, a novel method for analyzing reversible inhibition was carried out. Our alternative approach involves plotting the initial velocity at which product is formed as a