Výsledky vyhledávání - "Jordan L. Holtzman"

Akademický článek

Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's.

Autor: Brian Buijsse, Duk-Hee Lee, Lyn Steffen, Richard R Erickson, Russell V Luepker, David R Jacobs, Jordan L Holtzman

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38901 (2012)

BACKGROUND: Since oxidized LDL is thought to initiate atherosclerosis and the serum glutathione peroxidase (GPx3) reduces oxidized lipids, we investigated whether high GPx3 activity reduces cardiovascular disease (CVD) mortality. METHODS: We determin

Externí odkaz: https://doaj.org/article/8f05b74b3bcc47cda072739e0f3afb05

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Within-person variability of urinary 6β-hydroxycortisol to urinaryl ratios in Caucasian women

Autor: Zhi Chen, Lisa A. Dunning, Jordan L. Holtzman, Wei Zheng, Kristin E. Anderson

Publikováno v: Steroids. 69:67-70

Cortisol is metabolized to 6beta-hydroxycortisol by human cytochrome p450-3A4 (CYP3A4), an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds. Both cortisol and 6beta-hydroxycortisol are excreted in urine,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8486b60281521d9b374a89759a1ace0
https://doi.org/10.1016/j.steroids.2003.10.004

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Studies comparing the kinetics of cysteine conjugation and protein binding of acetaminophen by hepatic microsomes from male mice

Autor: Richard R. Erickson, Jordan L. Holtzman, Ling Xiang Zhou

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1335:153-160

A large body of evidence indicates that acetaminophen toxicity is mediated through the formation of the reactive metabolite, N-acetyl-p-benzoquinone imine (NABQI). Two assays have been employed to monitor NABQI formation by hepatic microsomes: the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad813dded5ca73d61662876e98605b9
https://doi.org/10.1016/s0304-4165(96)00132-8

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Cellular and Animal Models for High Through-Put Screening of Therapeutic Agentsfor the Treatment of the Diseases of the Elderly in Generaland Alzheimer’s Disease in Particular

Autor: Jordan L. Holtzman

Publikováno v: Frontiers in Pharmacology, Vol 4 (2013)
Frontiers in Pharmacology

It is currently thought that the dementia of Alzheimer’s disease is due to the neurotoxicity of the deposits or aggregates of amyloid-β (Aβ) in the extracellular space of the cerebral cortex. This model has been widely criticized because there is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0eda26ddcef47687cc2c1bc28fdac1
http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00059/full

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Metabolism of phenytoin by the gingiva of normal humans: The possible role of reactive metabolities of phenytoin in the initiation of gingival hyperplasia*

Autor: Jordan L. Holtzman, James P. Hardwick, Steven A. Wrighton, Ling Xiang Zhou, Bruce Pihlstrom, Sang S. Park

Publikováno v: Clinical Pharmacology & Therapeutics. 60:191-198

Gingival hyperplasia is a well-known complication of therapy with cyclosporine, calcium channel blockers, and phenytoin. It is characterized by the presence of inflammation and a marked fibrotic response. The mechanism of this adverse reaction is unk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d267a085eae4e3a439f708a84ea32218
https://doi.org/10.1016/s0009-9236(96)90135-6

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Evidence That Casein Kinase 2 Phosphorylates Hepatic Microsomal Calcium-Binding Proteins 1 and 2 but Not 3

Autor: Nengqain Chen, Bruce A. McKenzie, Said A. Goueli, Khalil Ahmed, Yuxiu Liu, Erhan C. Canbulat, Jordan L. Holtzman, Eric D. Eccleston, Alan T. Davis

Publikováno v: Biochemistry. 35:8299-8306

We have extensively purified three of the hepatic microsomal intralumenal Ca2+-binding proteins, CBP1, CBP2, and CBP3, which were originally described by Van et al. [(1989) J. Biol. Chem. 264, 17494-17501]. These apparently homogeneous preparations s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fddbc4b495c7d9bdd1b44b33efc0d7
https://doi.org/10.1021/bi960296e

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The Covalent Binding of [14C]Acetaminophen to Mouse Hepatic Microsomal Proteins: The Specific Binding to Calreticulin and the Two Forms of the Thiol:Protein Disulfide Oxidoreductases

Autor: Richard R. Erickson, Eric D. Eccleston, Jordan L. Holtzman, Nengqain Chen, Bruce A. McKenzie, Sri Prakash Srivastava, Lingxiang Zhou

Publikováno v: Chemical Research in Toxicology. 9:1176-1182

Numerous in vitro studies have indicated that acetaminophen is activated by mouse hepatic microsomal cytochrome P450 to form N-acetylbenzoquinone imine. This in turn covalently binds through a Michael addition to protein sulfhydryl and amino groups.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7c932c11c62c1c3e7c552929ba4030
https://doi.org/10.1021/tx960069d

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Cytochrome P450 Catalyzed Covalent Binding of Methoxychlor to Rat Hepatic, Microsomal Iodothyronine 5′-Monodeiodinase, Type I: Does Exposure to Methoxychlor Disrupt Thyroid Hormone Metabolism?

Autor: Bruce A. McKenzie, Ling Xiang Zhou, Shangara S. Dehal, Eric D. Eccleston, Jordan L. Holtzman, David Kupfer, Shana L. Morrell

Publikováno v: Archives of Biochemistry and Biophysics. 322:390-394

The insecticide methoxychlor is estrogenic in birds and mammals and interferes with sexual development and reproduction, but it is not known whether this toxicity is due solely to its estrogenicity. We now have found that during hepatic, microsomal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2976239cde31b2e503b783be42fa93ce
https://doi.org/10.1006/abbi.1995.1479

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