Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jordan Jacobelli"'
Autor:
Ashton L. Sigler, Scott B. Thompson, Logan Ellwood-Digel, Adithan Kandasamy, Mary J. Michaels, Dean Thumkeo, Shuh Narumiya, Juan C. Del Alamo, Jordan Jacobelli
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Lymphocyte trafficking and migration through tissues is critical for adaptive immune function and, to perform their roles, T cells must be able to navigate through diverse tissue environments that present a range of mechanical challenges. T cells pre
Externí odkaz:
https://doaj.org/article/8d8a242143d24c529f8431db63d56272
Autor:
Kelsey C. Haist, Sophie L. Gibbings, Jordan Jacobelli, Kara J. Mould, Peter M. Henson, Donna L. Bratton
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109589- (2024)
Summary: Sterile pyogranulomas and heightened cytokine production are hyperinflammatory hallmarks of Chronic Granulomatous Disease (CGD). Using peritoneal cells of zymosan-treated CGD (gp91phox−/−) versus wild-type (WT) mice, an ex vivo system of
Externí odkaz:
https://doaj.org/article/3319f50980b44809ac3b2750cd5c9663
Autor:
Monique M. Waldman, Jeremy T. Rahkola, Ashton L. Sigler, Jeffrey W. Chung, Benjamin A. S. Willett, Ross M. Kedl, Rachel S. Friedman, Jordan Jacobelli
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Naïve T cell activation in secondary lymphoid organs such as lymph nodes (LNs) occurs upon recognition of cognate antigen presented by antigen presenting cells (APCs). T cell activation requires cytoskeleton rearrangement and sustained interactions
Externí odkaz:
https://doaj.org/article/2f94a80c66674531848e898f60d561a1
Autor:
Scott B Thompson, Adam M Sandor, Victor Lui, Jeffrey W Chung, Monique M Waldman, Robert A Long, Miriam L Estin, Jennifer L Matsuda, Rachel S Friedman, Jordan Jacobelli
Publikováno v:
eLife, Vol 9 (2020)
Lymphocyte migration is essential for the function of the adaptive immune system, and regulation of T cell entry into tissues is an effective therapy in autoimmune diseases. Little is known about the specific role of cytoskeletal effectors that media
Externí odkaz:
https://doaj.org/article/05848d0787a543cab416fc0649eb8077
CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes
Autor:
Adam M. Sandor, Robin S. Lindsay, Nathan Dyjack, Jennifer C. Whitesell, Cydney Rios, Brenda J. Bradley, Kathryn Haskins, David V. Serreze, Aron M. Geurts, Yi-Guang Chen, Max A. Seibold, Jordan Jacobelli, Rachel S. Friedman
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that affects more than 19 million people with incidence increasing rapidly worldwide. For T cells to effectively drive T1D, they must first traffic to the islets and extravasate through th
Externí odkaz:
https://doaj.org/article/84f626d760c74ffda3d49e544096b774
Autor:
Hawa-Racine Thiam, Pablo Vargas, Nicolas Carpi, Carolina Lage Crespo, Matthew Raab, Emmanuel Terriac, Megan C. King, Jordan Jacobelli, Arthur S. Alberts, Theresia Stradal, Ana-Maria Lennon-Dumenil, Matthieu Piel
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cell migration through micrometric constraints is limited by low deformability of the nucleus. Here the authors show that in dendritic cells a perinuclear actin network nucleated by Arp2/3 increases nuclear deformation and allows the cells to pass th
Externí odkaz:
https://doaj.org/article/796be198360b48fbb790124ac2cd0cd1
Autor:
Scott B. Thompson, Eric J. Wigton, Sai Harsha Krovi, Jeffrey W. Chung, Robert A. Long, Jordan Jacobelli
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Leukemias typically arise in the bone marrow and then spread to the blood and into other tissues. To disseminate into tissues, leukemia cells migrate into the blood stream and then exit the circulation by migrating across vascular endothelial barrier
Externí odkaz:
https://doaj.org/article/afc9c01cb6db49a2b593407fb3cd88a6
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75151 (2013)
Following activation, T cells are released from lymph nodes to traffic via the blood to effector sites. The re-entry of these activated T cells into tissues represents a critical step for them to carry out local effector functions. Here we have asses
Externí odkaz:
https://doaj.org/article/72450fb457514acd90fb647c06135b37
Autor:
Edward M. Gardner, Lindsay K. Nicholson, Edward N. Janoff, James Scott, Vibha Jha, Jordan Jacobelli, Jeremy T Rahkola, Mandy Borgeson, Harsh Pratap
Publikováno v:
The Journal of Immunology. 206:2402-2411
Pneumococcal infections are common and serious complications of HIV-1 disease. Prevention has been compromised by the limited magnitude and quality of Ab responses to T cell–independent type 2 pneumococcal capsular polysaccharides (PPS). The pneumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7da4b633bbd4eead67935b0ac2cb8de
https://doi.org/10.4049/jimmunol.2001133
https://doi.org/10.4049/jimmunol.2001133
Publikováno v:
Immunol Rev
Autoimmunity arises when mechanisms of immune tolerance fail. Here we discuss mechanisms of T cell activation and tolerance and the dynamics of the autoimmune response at the site of disease. Live imaging of autoimmunity provides the ability to analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a558da6a2908ade72835bec0e9f42ac3
https://pubmed.ncbi.nlm.nih.gov/34825390
https://pubmed.ncbi.nlm.nih.gov/34825390