Aversive Behavior in the Nematode C. elegans Is Modulated by cGMP and a Neuronal Gap Junction Network.

Autor: Michelle C Krzyzanowski, Sarah Woldemariam, Jordan F Wood, Aditi H Chaubey, Chantal Brueggemann, Alexander Bowitch, Mary Bethke, Noelle D L'Etoile, Denise M Ferkey

Publikováno v: PLoS Genetics, Vol 12, Iss 7, p e1006153 (2016)

All animals rely on their ability to sense and respond to their environment to survive. However, the suitability of a behavioral response is context-dependent, and must reflect both an animal's life history and its present internal state. Based on th

Externí odkaz: https://doaj.org/article/bcf23d9fbc4c42d7bb22592713d27fff

The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons

Autor: Erdem Varol, Amelia Antone, Emily Berghoff, Steven J. Cook, Cyril Cros, Jordan F. Wood, Abhishek Bhattacharya, Yi Feng, Lori Glenwinkel, Neda Masoudi, Denise M. Ferkey, David H. Hall, Oliver Hobert, Yasmin H Ramadan, Ken Nguyen, HaoSheng Sun, Nicki Mohammadi

Publikováno v: eLife, Vol 10 (2021)

Many neuronal identity regulators are expressed in distinct populations of cells in the nervous system, but their function is often analyzed only in specific isolated cellular contexts, thereby potentially leaving overarching themes in gene function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf6e4ac1d8aae3d91e6fd6654097428
https://doi.org/10.7554/elife.64903

The Prop1-like homeobox gene

Autor: Emily G, Berghoff, Lori, Glenwinkel, Abhishek, Bhattacharya, HaoSheng, Sun, Erdem, Varol, Nicki, Mohammadi, Amelia, Antone, Yi, Feng, Ken, Nguyen, Steven J, Cook, Jordan F, Wood, Neda, Masoudi, Cyril C, Cros, Yasmin H, Ramadan, Denise M, Ferkey, David H, Hall, Oliver, Hobert

Publikováno v: eLife

Many neuronal identity regulators are expressed in distinct populations of cells in the nervous system, but their function is often analyzed only in specific isolated cellular contexts, thereby potentially leaving overarching themes in gene function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4648190ad4f6b11ea2d16026fe9c47f8
https://pubmed.ncbi.nlm.nih.gov/34165428

The C. elegans cGMP-Dependent Protein Kinase EGL-4 Regulates Nociceptive Behavioral Sensitivity

Autor: Chantal Brueggemann, Kimberly D. Collins, Christopher A. Jackson, Denise M. Ferkey, Michelle C. Krzyzanowski, Noelle D. L'Etoile, Meredith J. Ezak, Michael C. Yu, Bi-Tzen Juang, Jordan F. Wood, Kerry L. Michaels

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 9, Iss 7, p e1003619 (2013)
L'Etoile, Noelle; Krzyzanowski, MC; Brueggemann, C; Ezak, MJ; Wood, JF; Michaels, KL; et al.(2013). The C. elegans cGMP-Dependent Protein Kinase EGL-4 Regulates Nociceptive Behavioral Sensitivity. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/85x534mj

Signaling levels within sensory neurons must be tightly regulated to allow cells to integrate information from multiple signaling inputs and to respond to new stimuli. Herein we report a new role for the cGMP-dependent protein kinase EGL-4 in the neg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f49052c4370264d38d9b93de9c5b56
http://europepmc.org/articles/PMC3708839

Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo

Autor: Jeffrey L. Benovic, Jianjun Wang, Denise M. Ferkey, Jordan F. Wood

Publikováno v: The Journal of biological chemistry. 287(16)

G protein-coupled receptor kinases (GRKs) are key regulators of signal transduction that specifically phosphorylate activated G protein-coupled receptors (GPCRs) to terminate signaling. Biochemical and crystallographic studies have provided great ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810256ebe405ef967eaa3af3267c2c5f
https://pubmed.ncbi.nlm.nih.gov/22375004