Výsledky vyhledávání - "Jordan E Burke"

Akademický článek

A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.

Autor: Cedric A Brimacombe, Jordan E Burke, Jahan-Yar Parsa, Sandra Catania, Teresa R O'Meara, Jessica N Witchley, Laura S Burrack, Hiten D Madhani, Suzanne M Noble

Publikováno v: PLoS Biology, Vol 17, Iss 6, p e3000331 (2019)

Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress. Here, we identify a chromatin-based system req

Externí odkaz: https://doaj.org/article/bf4b51dfd9104c519b547c34c1aeb20a

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A Non-Dicer RNase III and Four Other Novel Factors Required for RNAi-Mediated Transposon Suppression in the Human Pathogenic Yeast Cryptococcus neoformans

Autor: Jolene K. Diedrich, Jade Sales-Lee, Beiduo Rao, Prashanthi Natarajan, Yasaman Mortensen, Hiten D. Madhani, S. John Liu, John R. Yates, James J. Moresco, Adam D. Longhurst, Jordan E. Burke

Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2235-2244 (2019)

The human pathogenic yeast Cryptococcus neoformans silences transposable elements using endo-siRNAs and an Argonaute, Ago1. Endo-siRNAs production requires the RNA-dependent RNA polymerase, Rdp1, and two partially redundant Dicer enzymes, Dcr1 and Dc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32e793dddcb4cafa7b7159ded1a4238
http://g3journal.org/lookup/doi/10.1534/g3.119.400330

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Polymerase pausing induced by sequence-specific RNA-binding protein drives heterochromatin assembly

Autor: Selim Boudoukha, Jordan E. Burke, Christina M. Homer, Hiten D. Madhani, Jahan-Yar Parsa

Publikováno v: Genes & Development. 32:953-964

Packaging of pericentromeric DNA into heterochromatin is crucial for genome stability, development and health, yet its endogenous triggers remain poorly understood1. A defining feature of pericentromeric heterochromatin is histone H3 lysine 9 methyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883af6fb35d2ff158a5f0e5c8c80d0ea
https://doi.org/10.1101/gad.310136.117

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Conformational flexibility in the enterovirus RNA replication platform

Autor: Jordan E. Burke, Steven M. Pascal, Komala Ponniah, Samuel E. Butcher, Kai Cai, Gabriel Cornilescu, Meghan S. Warden

A presumed RNA cloverleaf (5′CL), located at the 5′-most end of the noncoding region of the enterovirus genome, is the primary established site for initiation of genomic replication. Stem–loop B (SLB) and stem–loop D (SLD), the two largest st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8c739ca2a4e8a3137a2b5cf809f6a1
https://europepmc.org/articles/PMC6380274/

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Analytical validation of a tissue agnostic ctDNA MRD assay using tumor specific methylation and somatic variant profiles in early-stage CRC

Autor: Farsheed Ghadiri, Anna Hartwig, Dustin Hite, Marisa Juntilla, Mahmoud Dahdouli, Jordan E. Burke, Tracy Nance, Sweta Sharma, Darya Chudova, AmirAli Talasaz, Jessica Kurata, Carlo Artieri, Saiyou Ohshima, Yupeng He, Oscar Westesson, Ariel Jaimovich, Haley Axelrod, Arthur Baca, Yu Kong

Publikováno v: Journal of Clinical Oncology. 38:e15549-e15549

e15549 Background: Liquid biopsy is a candidate for detection of minimal residual disease (MRD) in early colorectal cancer. Detection of circulating tumor (ct)DNA in early stage cancer is challenging given the low abundance of ctDNA molecules. We dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c35d32131a849f77eb4400453bdaa3e6
https://doi.org/10.1200/jco.2020.38.15_suppl.e15549

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Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase

Autor: Sandra Catania, John R. Yates, Terrance Shea, Harold Pimentel, Robert E. Lintner, Caitlin I. Stoddard, Jolene K. Diedrich, Geeta J. Narlikar, Elizabeth Gienger, Ammar Nasif, Petra Hajkova, Sophie Cooke, Christina A. Cuomo, Hiten D. Madhani, Phillip A. Dumesic, Jonathan K. Pritchard, Jordan E. Burke

Publikováno v: Cell

SUMMARYCytosine methylation of DNA is a widespread modification of DNA that plays numerous critical roles, yet has been lost many times in diverse eukaryotic lineages. In the yeastCryptococcus neoformans, CG methylation occurs in transposon-rich repe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1e809047431ff56254abd210d77998
https://doi.org/10.1016/j.cell.2020.02.006

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Chromatin rewiring mediates programmed evolvability via aneuploidy

Autor: Cedric A. Brimacombe, Jahan-Yar Parsa, Jessica N. Witchley, Hiten D. Madhani, Suzanne M. Noble, Laura S. Burrack, Jordan E. Burke

Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis1, and yet specific aneuploidies can be adaptive during environmental stress2,3. Here, we identify a chromatin-based system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af016343fcacf9b52261215d1a905200
https://doi.org/10.1101/407841

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Spliceosome Profiling Visualizes Operations of a Dynamic RNP at Nucleotide Resolution

Autor: Jingyi Jessica Li, John R. Yates, James J. Moresco, Hiten D. Madhani, Daria Merkurjev, Jordan E. Burke, Adam D. Longhurst, Beiduo Rao, Jade Sales-Lee

Publikováno v: Cell, vol 173, iss 4
Burke, JE; Longhurst, AD; Merkurjev, D; Sales-Lee, J; Rao, B; Moresco, JJ; et al.(2018). Spliceosome Profiling Visualizes Operations of a Dynamic RNP at Nucleotide Resolution. Cell, 173(4), 1014-1030.e17. doi: 10.1016/j.cell.2018.03.020. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9722m74v

© 2018 Elsevier Inc. Tools to understand how the spliceosome functions in vivo have lagged behind advances in the structural biology of the spliceosome. Here, methods are described to globally profile spliceosome-bound pre-mRNA, intermediates, and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fa25cb514e4efbd67099f0633bc14f
https://escholarship.org/uc/item/9722m74v

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Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation

Autor: Edwin R. Chapman, Amber L. Schuh, Jennifer Bird, Samuel E. Butcher, Anjon Audhya, E. B. Franke, Erin L. Slosarek, Scott M. Stagg, Michael D. Sheets, David A. Ruhl, Kyle Quinney, Jordan E. Burke, Michael G. Hanna, Adam Johnson, Nilakshee Bhattacharya, Matthew C. Johnson

Publikováno v: SSRN Electronic Journal.

Length-dependent axonopathy of the corticospinal tract causes lower limb spasticity and weakness and is characteristic of several neurological disorders, including hereditary spastic paraplegia (HSP) and amyotrophic lateral sclerosis (ALS). Mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46e7ac3564fea31229c6d753151ae7f0
https://doi.org/10.2139/ssrn.3155929

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Structural mechanisms of DNA binding and unwinding in bacterial RecQ helicases

Autor: Jordan E. Burke, Morgan C. Hill, Kelly A. Manthei, Samuel E. Butcher, James L. Keck

Publikováno v: Proceedings of the National Academy of Sciences. 112:4292-4297

RecQ helicases unwind remarkably diverse DNA structures as key components of many cellular processes. How RecQ enzymes accommodate different substrates in a unified mechanism that couples ATP hydrolysis to DNA unwinding is unknown. Here, the X-ray cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a29238ba314d22b49c13ba62e564d56
https://doi.org/10.1073/pnas.1416746112

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