Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Jordan D. Dimitrov"'
Autor:
Nia Toshkova, Violeta Zhelyzkova, Alejandra Reyes-Ruiz, Eline Haerens, Marina de Castro Deus, Robin V. Lacombe, Maxime Lecerf, Gaelle Gonzalez, Nolwenn Jouvenet, Cyril Planchais, Jordan D. Dimitrov
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The bat immune system features multiple unique properties such as dampened inflammatory responses and increased tissue protection, explaining their long lifespan and tolerance to viral infections. Here, we demonstrated that body temperature
Externí odkaz:
https://doaj.org/article/13f32342da5a482e90b688394328e434
Autor:
Cyril Planchais, Ignacio Fernández, Benjamin Chalopin, Timothée Bruel, Pierre Rosenbaum, Maxime Beretta, Jordan D. Dimitrov, Laurine Conquet, Flora Donati, Matthieu Prot, Françoise Porrot, Delphine Planas, Isabelle Staropoli, Florence Guivel-Benhassine, Eduard Baquero, Sylvie van der Werf, Ahmed Haouz, Etienne Simon-Lorière, Xavier Montagutelli, Bernard Maillère, Félix A. Rey, Pablo Guardado-Calvo, Hervé Nozach, Olivier Schwartz, Hugo Mouquet
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110354- (2024)
Summary: Antibodies play a pivotal role in protecting from SARS-CoV-2 infection, but their efficacy is challenged by the continuous emergence of viral variants. In this study, we describe two broadly neutralizing antibodies cloned from the memory B c
Externí odkaz:
https://doaj.org/article/c653ff8957ad4f029dc47c33231f0107
Autor:
Cyril Planchais, Luis M. Molinos-Albert, Pierre Rosenbaum, Thierry Hieu, Alexia Kanyavuz, Dominique Clermont, Thierry Prazuck, Laurent Lefrou, Jordan D. Dimitrov, Sophie Hüe, Laurent Hocqueloux, Hugo Mouquet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract HIV-1 infection causes severe alterations of gut mucosa, microbiota and immune system, which can be curbed by early antiretroviral therapy. Here, we investigate how treatment timing affects intestinal memory B-cell and plasmablast repertoire
Externí odkaz:
https://doaj.org/article/721b42fa56454c4cb5fce2e7f31a7b08
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
An antibody molecule that can bind to multiple distinct antigens is defined as polyreactive. In the present study, we performed statistical analyses to assess sequence correlates of polyreactivity of >600 antibodies cloned from different B-cell types
Externí odkaz:
https://doaj.org/article/d90610c442ff48beae4027eb5ffd1970
Autor:
Cyril Planchais, Remi Noe, Marie Gilbert, Maxime Lecerf, Srini V. Kaveri, Sébastien Lacroix-Desmazes, Lubka T. Roumenina, Jordan D. Dimitrov
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Oxidized hemoglobin induces polyreactivity and autoreactivity of human IgG through direct transfer and binding of heme to the variable region of IgG, which contributes to a better understanding of the physiopathology of hemolytic diseases.
Externí odkaz:
https://doaj.org/article/f7705e6c7787475685bc115f0bcea333
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/25eb5069e2a74dba9926a6758927b88e
Autor:
Melissa Bou-Jaoudeh, Sandrine Delignat, Victoria Daventure, Jan Astermark, Hervé Lévesque, Jordan D. Dimitrov, Claire Deligne, Valérie Proulle, Sébastien Lacroix-Desmazes
Publikováno v:
Haematologica, Vol 108, Iss 5 (2023)
Neutralizing anti-factor VIII (FVIII) antibodies, known as FVIII inhibitors, represent a major drawback of replacement therapy in persons with congenital hemophilia A (PwHA), rendering further infusions of FVIII ineffective. FVIII inhibitors can also
Externí odkaz:
https://doaj.org/article/9ef633a3841246aeb61a09081db47918
Autor:
Alexandra Gerogianni, Jordan D. Dimitrov, Alessandra Zarantonello, Victoria Poillerat, Satheesh Chonat, Kerstin Sandholm, Karin E. McAdam, Kristina N. Ekdahl, Tom E. Mollnes, Camilla Mohlin, Lubka T. Roumenina, Per H. Nilsson
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma. The liberation of heme has been linked to the act
Externí odkaz:
https://doaj.org/article/0a05f1bf9b5b4cc29cb6730c4a4c8d47
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme. They find that those that do interact with heme possess specific sequence traits tha
Externí odkaz:
https://doaj.org/article/af921751134f450894b0f294ada57a9b
Autor:
Marie Wiatr, Maya Hadzhieva, Maxime Lecerf, Rémi Noé, Sune Justesen, Sébastien Lacroix-Desmazes, Marie-Agnès Dragon-Durey, Jordan D. Dimitrov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3416 (2023)
The interaction of some human antibodies with heme results in posttranslational acquisition of binding to various self- and pathogen-derived antigens. The previous studies on this phenomenon were performed with oxidized heme (Fe3+). In the present st
Externí odkaz:
https://doaj.org/article/e1c5d20a77d44e4880350de066218a9b