Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jordan Cran"'
Autor:
Jonathan K. M. Lim, Arash Samiei, Alberto Delaidelli, Jessica Oliveira de Santis, Vanessa Brinkmann, Christopher J. Carnie, Daniel Radiloff, Laura Hruby, Alisa Kahler, Jordan Cran, Gabriel Leprivier, Poul H. Sorensen
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-10 (2024)
Abstract Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a stress-responsive hub that inhibits the translation elongation factor eEF2, and consequently mRNA translation elongation, in response to hypoxia and nutrient deprivation. EEF2K is als
Externí odkaz:
https://doaj.org/article/6835837b84d7441fa2ee38d01cd997d9
Autor:
Joshua S. Clayton, Christina Vo, Jordan Crane, Carolin K. Scriba, Safaa Saker, Thierry Larmonier, Edoardo Malfatti, Norma B. Romero, Gianina Ravenscroft, Nigel G. Laing, Rhonda L. Taylor
Publikováno v:
Stem Cell Research, Vol 80, Iss , Pp 103491- (2024)
Variants in MYH7 cause cardiomyopathies as well as myosin storage myopathy and Laing early-onset distal myopathy (MPD1). MPD1 is characterized by muscle weakness and atrophy usually beginning in the lower legs. Here, we generated iPSC lines from lymp
Externí odkaz:
https://doaj.org/article/3d5d74df28c54775a784033792ebea4b
Autor:
Joshua S. Clayton, Christina Vo, Jordan Crane, Carolin K. Scriba, Safaa Saker, Thierry Larmonier, Edoardo Malfatti, Norma B. Romero, Gianina Ravenscroft, Nigel G. Laing, Rhonda L. Taylor
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103411- (2024)
RYR1 variants are a common cause of congenital myopathies, including multi-minicore disease (MmD) and central core disease (CCD). Here, we generated iPSC lines from two CCD patients with dominant RYR1 missense variants that affect the transmembrane (
Externí odkaz:
https://doaj.org/article/a2f31142d3c04bd2b691d66e91321b37
Autor:
Joshua S. Clayton, Christina Vo, Jordan Crane, Carolin K. Scriba, Safaa Saker, Thierry Larmonier, Edoardo Malfatti, Norma B. Romero, Gianina Ravenscroft, Nigel G. Laing, Rhonda L. Taylor
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103410- (2024)
RYR1 variants are the most common genetic cause of congenital myopathies, and typically cause central core disease (CCD) and/or malignant hyperthermia (MH). Here, we generated iPSC lines from two patients with CCD and MH caused by dominant RYR1 varia
Externí odkaz:
https://doaj.org/article/83937e9ad64641f5b8a74afaa10b22c6
Autor:
Xue Qi Wang, Fan Zhang, Syam Prakash Somasekharan, Jordan Cran, Olivier Delattre, Melvin Pan, Christopher S. Hughes, Hongwei Cheng, Yemin Wang, Poul H. Sorensen, David G. Huntsman, Anna Mandinova, Amal El-Naggar, Hai-Feng Zhang, Shane Colborne, Yuzhuo Wang, Didier Surdez, Bo Rafn, Gian Luca Negri, Martin E. Gleave, Nancy Kedersha, Gregg B. Morin, Alberto Delaidelli
Publikováno v:
EMBO Reports
Outcomes for metastatic Ewing sarcoma and osteosarcoma are dismal and have not changed for decades. Oxidative stress attenuates melanoma metastasis, and melanoma cells must reduce oxidative stress to metastasize. We explored this in sarcomas by scree
Autor:
Jordan Cran, Gabriel Leprivier, Marcel Kool, Poul H. Sorensen, Alberto Delaidelli, Simran Sidhu, John M. Maris, Stefan M. Pfister, Gian Luca Negri, Michael D. Taylor, Marc Remke
Publikováno v:
Neuro-Oncology. 20:i140-i140
BACKGROUND: The MYC oncogenes contribute to more than 50% of all human cancers, but their therapeutic targeting has proven challenging. MYC/MYCN amplification in childhood medulloblastoma (MB) and neuroblastoma (NB) determine aggressive disease and h
Autor:
Peter C. Chua, Jordan Cran, Karlo Kordic, Jason S. Tan, Geoffrey C. Winters, James W. Evans, Andrew I. Minchinton, Alastair H. Kyle, Jerome Lozada, Kirstin E. Lindquist
Publikováno v:
Tumor Microenvironment and Therapy. 1
Tumour hypoxia presents a barrier to conventional chemotherapy and radiation therapy. To combat hypoxic cells a number of hypoxia modifying treatments are currently in development. In this study we assessed the potential for inhibiting DNA double str
Autor:
Jordan Cran, Kirsten L. Bartels, Andrew Balbirnie, Erin J. Flanagan, Andrew I. Minchinton, Alastair H. Kyle, Stephen P. Methot, Jennifer H.E. Baker
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76832 (2013)
PLoS ONE
PLoS ONE
Many cancer research efforts focus on exploiting genetic-level features that may be targeted for therapy. Tissue-level features of the tumour microenvironment also represent useful therapeutic targets. Here we investigate the presence of low oxygen t
Autor:
Haley Patrick, Jordan Cran, Maria-Jose Gandolfo, Andrew I. Minchinton, Alastair H. Kyle, Jennifer H.E. Baker
Publikováno v:
Molecular Cancer Research. 14:B32-B32
Despite significant success, the response of Her2+ patients to trastuzumab (TzMAb, Herceptin ®) is varied, with many still experiencing tumor progression. We have used 3D tissue, tumor xenograft and metastatic models to examine the microregional dis
Autor:
Andrew I. Minchinton, Alastair H. Kyle, Urs O. Häfeli, Firas Moosvi, Jordan Cran, Katayoun Saatchi, Jennifer H.E. Baker, Stefan A. Reinsberg
Publikováno v:
Cancer Research. 74:2988-2988
We have previously shown that trastuzumab distributes heterogeneously within MDA-435-Her2 xenografts. Though peak accumulation occurs 24h after administration & trastuzumab was detected greater than 150 µm from many vessels, there remained substanti