Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia.

Autor: Stiff A; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Fornerod M; Department of Cell Biology, Erasmus Medical Center, Rotterdam, the Netherlands., Kain BN; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Nicolet D; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Kelly BJ; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Miller KE; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA., Mrózek K; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Boateng I; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Bollas A; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Garfinkle EAR; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Momoh O; Department of Internal Medicine, Montefiore Health System/Albert Einstein College of Medicine, New York, NY, USA., Fasola FA; Department of Hematology, Faculty of Basic Medical Science, University of Ibadan, University College Hospital, Ibadan, Nigeria., Olawumi HO; Department of Haematology, University of Ilorin, Ilorin, Nigeria., Mencia-Trinchant N; Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Kloppers JF; School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.; National Health Laboratory Service, Universitas Academic Business Unit, Bloemfontein, South Africa., van Marle AC; School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.; National Health Laboratory Service, Universitas Academic Business Unit, Bloemfontein, South Africa., Hu E; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Department of Internal Medicine, University of Texas Southwestern, Dallas, TX, USA., Wijeratne S; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Wheeler G; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Walker CJ; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Buss J; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Heyrosa A; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Desai H; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Laganson A; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Hamp E; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Abu-Shihab Y; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Abaza H; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Kronen P; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Sen S; Divison of Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH, USA., Johnstone ME; Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA., Quinn K; Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA., Wronowski B; Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA., Hertlein E; Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA., Miles LA; Cancer and Blood Diseases Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA., Mims AS; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Oakes CC; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Blachly JS; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Larkin KT; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Mundy-Bosse B; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Carroll AJ; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA., Powell BL; Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA., Kolitz JE; Monter Cancer Center, Hofstra Northwell School of Medicine, Lake Success, NY, USA., Stone RM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Duarte C; University of Colorado, Anschutz Medical Campus, College of Medicine, Denver, CO, USA., Abbott D; University of Colorado, Anschutz Medical Campus, College of Medicine, Denver, CO, USA., Amaya ML; University of Colorado, Anschutz Medical Campus, College of Medicine, Denver, CO, USA., Jordan CT; University of Colorado, Anschutz Medical Campus, College of Medicine, Denver, CO, USA., Uy GL; Washington University School of Medicine, Saint Louis, MO, USA., Stock W; University of Chicago, College of Medicine, Chicago, IL, USA., Archer KJ; Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, USA., Paskett ED; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.; Division of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA., Guzman ML; Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, New York, NY, USA., Levine RL; Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Menghrajani K; Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Chakravarty D; Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Berger MF; Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Bottomly D; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., McWeeney SK; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Tyner JW; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Byrd JC; Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA., Salomonis N; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Grimes HL; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Mardis ER; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Elaine.Mardis@nationwidechildrens.org.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA. Elaine.Mardis@nationwidechildrens.org., Eisfeld AK; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Ann-Kathrin.Eisfeld@osumc.edu.; Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Ann-Kathrin.Eisfeld@osumc.edu.; Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Ann-Kathrin.Eisfeld@osumc.edu.

Publikováno v: Nature genetics [Nat Genet] 2024 Nov; Vol. 56 (11), pp. 2434-2446. Date of Electronic Publication: 2024 Oct 04.

Understanding MDS stem cells: Advances and limitations.

Autor: Patel SB; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora CO., Moskop DR; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora CO., Jordan CT; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora CO. Electronic address: Craig.Jordan@cuanschutz.edu., Pietras EM; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora CO. Electronic address: Eric.Pietras@cuanschutz.edu.

Publikováno v: Seminars in hematology [Semin Hematol] 2024 Sep 28. Date of Electronic Publication: 2024 Sep 28.

MYC Inhibition Potentiates CD8+ T Cells Against Multiple Myeloma and Overcomes Immunomodulatory Drug Resistance.

Autor: Davis LN; Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Walker ZJ; Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Reiman LT; Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Parzych SE; Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Stevens BM; Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Jordan CT; Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Forsberg PA; Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado., Sherbenou DW; Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.; University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Jul 15; Vol. 30 (14), pp. 3023-3035.

In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia.

Autor: Sahasrabudhe DM; Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY, 14618, USA. Deepak_Sahasrabudhe@urmc.rochester.edu.; Department of Medicine, Hematology/Oncology, University of Rochester Medical Center, Rochester, NY, USA. Deepak_Sahasrabudhe@urmc.rochester.edu., Liesveld JL; Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY, 14618, USA.; Department of Medicine, Hematology/Oncology, University of Rochester Medical Center, Rochester, NY, USA., Minhajuddin M; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, US., Singh NA; Department of Medicine, Hematology/Oncology, University of Rochester Medical Center, Rochester, NY, USA., Nath S; Department of Chemistry, Birla Institute of Technology, Ranchi, Jharkhand, India., Kumar VM; Department of Chemistry, Birla Institute of Technology, Ranchi, Jharkhand, India., Balys M; Genomics Research Center, University of Rochester Medical Center, Rochester, NY, USA., Evans AG; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Azadniv M; Department of Medicine, Hematology/Oncology, University of Rochester Medical Center, Rochester, NY, USA., Hansen JN; Department of Psychological and Brain Sciences, Colgate University, Hamilton, NY, USA., Becker MW; Indiana University School of Medicine, Indianapolis, IN, USA., Sharon A; Department of Chemistry, Birla Institute of Technology, Ranchi, Jharkhand, India., Thomas VK; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, 14642, USA., Moore RG; Division of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, USA., Khera MK; Presude Lifesciences Pvt Ltd., Uttam Nagar, New Delhi, 110059, India., Jordan CT; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, US., Singh RK; Division of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, USA. Rakesh_Singh@urmc.rochester.edu.; Wilmot Cancer Institute, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY, 14642, USA. Rakesh_Singh@urmc.rochester.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Jun 04; Vol. 14 (1), pp. 12868. Date of Electronic Publication: 2024 Jun 04.

Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid Leukemia.

Autor: Rodems BJ; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA., Sharma S; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA., Baker CD; Genomics Research Center, University of Rochester Medical Center, Rochester, NY 14642, USA., Kaszuba CM; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.; Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA., Ito T; Department of Bioscience and Technology, Graduate School of Bioscience and Technology, Fukui Prefectural University, Fukui, Japan., Liesveld JL; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.; Division of Hematology and Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA., Calvi LM; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.; Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA., Becker MW; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.; Division of Hematology and Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA., Jordan CT; Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Ashton JM; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.; Genomics Research Center, University of Rochester Medical Center, Rochester, NY 14642, USA., Bajaj J; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 14. Date of Electronic Publication: 2024 May 14.