Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jordan C. O'Neill"'
Autor:
Sichen Chang, Jonathan W. Dickerson, Baker Logan A, Thomas M. Bridges, Craig W. Lindsley, Darren W. Engers, Aidong Qi, Jerri M. Rook, Aaron M. Bender, P. Jeffrey Conn, Katrina A. Bollinger, Colleen M. Niswender, Changho Han, Alice L. Rodriguez, Trever R Carter, Li Peng, Julie L. Engers, Jordan C. O’Neill, Matthew Spock, Katherine J. Watson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein, we report the SAR leading to the discovery of VU6028418, a potent M(4) mAChR antagonist with high subtype-selectivity and attractive DMPK properties in vitro and in vivo across multiple species. VU6028418 was subsequently ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388290e5061b99e6a85f95357b9a3b32
https://doi.org/10.1021/acsmedchemlett.1c00363
https://doi.org/10.1021/acsmedchemlett.1c00363
Autor:
Jerri M. Rook, Aaron M. Bender, Colleen M. Niswender, Yuping Donsante, P. Jeffrey Conn, Hyekyung P. Cho, Li Peng, Julie L. Engers, Jonathan W. Dickerson, Thomas M. Bridges, Craig W. Lindsley, Ellen J. Hess, Sichen Chang, Aidong Qi, Weimin Peng, Mark S. Moehle, Jordan C. O’Neill, Daniel J. Foster, Alice L. Rodriguez, Zoey Bryant, Katherine J. Watson, Kaylee J. Stillwell
Publikováno v:
ACS Pharmacology & Translational Science. 4:1306-1321
Nonselective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson's disease and dystonia. Despite their efficacy in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5425dfe0a6fb74da410878130ec6660
https://doi.org/10.1021/acsptsci.0c00162
https://doi.org/10.1021/acsptsci.0c00162
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006638 (2017)
Coordination between cell division and chromosome replication is essential for a cell to produce viable progeny. In the commonly accepted view, Escherichia coli realize this coordination via the accurate positioning of its cell division apparatus rel
Externí odkaz:
https://doaj.org/article/7b08306f17a04e018828136e0f437c42
Autor:
Sichen Chang, Ellen J. Hess, Jerri M. Rook, Jonathan W. Dickerson, Colleen M. Niswender, Yuping Donsante, Weimin Peng, Craig W. Lindsley, Li Peng, Julie L. Engers, Thomas M. Bridges, Mark S. Moehle, Daniel J. Foster, P. Jeffrey Conn, Aaron M. Bender, Alice L. Rodriguez, Zoey Bryant, Katherine J. Watson, Jordan C. O’Neill
Non-selective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson disease and dystonia. Despite their efficacy in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2f6ae5b896aa0960348eb4cabab3c6e
https://doi.org/10.1101/2020.10.12.324152
https://doi.org/10.1101/2020.10.12.324152
Autor:
Mark S, Moehle, Aaron M, Bender, Jonathan W, Dickerson, Daniel J, Foster, Aidong, Qi, Hyekyung P, Cho, Yuping, Donsante, Weimin, Peng, Zoey, Bryant, Kaylee J, Stillwell, Thomas M, Bridges, Sichen, Chang, Katherine J, Watson, Jordan C, O'Neill, Julie L, Engers, Li, Peng, Alice L, Rodriguez, Colleen M, Niswender, Craig W, Lindsley, Ellen J, Hess, P Jeffrey, Conn, Jerri M, Rook
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Nonselective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson’s disease and dystonia. Despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::201a9605778eafcb97e04614395cae35
https://pubmed.ncbi.nlm.nih.gov/34423268
https://pubmed.ncbi.nlm.nih.gov/34423268
Autor:
Kellie D. Nance, Colleen M. Niswender, Christopher J. Langmead, Aaron M. Bender, Hyekyung P. Cho, Karl R. Voigtritter, P. Jeffrey Conn, Carrie K. Jones, Thomas M. Bridges, Sichen Chang, Patrick R. Gentry, Vincent B. Luscombe, Kaelyn S. Lingenfelter, Alice E. Berizzi, Jordan C. O’Neill, Craig W. Lindsley, Arthur Christopoulos, Charles W. Locuson, Patrick M. Sexton, Xiaoyan Zhan
Publikováno v:
ACS Chemical Neuroscience. 9:1572-1581
The pharmacology of the M5 muscarinic acetylcholine receptor (mAChR) is the least understood of the five mAChR subtypes due to a historic lack of selective small molecule tools. To address this shortcoming, we have continued the optimization effort a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16e38b3b033988bef5ccd6f3c551fb2
https://doi.org/10.1021/acschemneuro.8b00126
https://doi.org/10.1021/acschemneuro.8b00126
Autor:
Aaron M, Bender, Hyekyung P, Cho, Kellie D, Nance, Kaelyn S, Lingenfelter, Vincent B, Luscombe, Patrick R, Gentry, Karl, Voigtritter, Alice E, Berizzi, Patrick M, Sexton, Christopher J, Langmead, Arthur, Christopoulos, Charles W, Locuson, Thomas M, Bridges, Sichen, Chang, Jordan C, O'Neill, Xiaoyan, Zhan, Colleen M, Niswender, Carrie K, Jones, P Jeffrey, Conn, Craig W, Lindsley
Publikováno v:
ACS chemical neuroscience. 9(7)
[Image: see text] The pharmacology of the M(5) muscarinic acetylcholine receptor (mAChR) is the least understood of the five mAChR subtypes due to a historic lack of selective small molecule tools. To address this shortcoming, we have continued the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::591af45d955d6d8ab49f9660a56fee9a
https://pubmed.ncbi.nlm.nih.gov/29678111
https://pubmed.ncbi.nlm.nih.gov/29678111
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 13, Iss 2, p e1006638 (2017)
PLoS Genetics, Vol 13, Iss 2, p e1006638 (2017)
Coordination between cell division and chromosome replication is essential for a cell to produce viable progeny. In the commonly accepted view, Escherichia coli realize this coordination via the accurate positioning of its cell division apparatus rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16c919d4d737741a7cee528442e0f14
https://doi.org/10.1371/journal.pgen.1006638
https://doi.org/10.1371/journal.pgen.1006638