Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jordan C Langston"'
Autor:
Jordan C Langston, Michael T Rossi, Qingliang Yang, William Ohley, Edwin Perez, Laurie E Kilpatrick, Balabhaskar Prabhakarpandian, Mohammad F Kiani
Publikováno v:
Vascular Biology, Vol 4, Iss 1, Pp R15-R34 (2022)
During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, resulting in inc
Externí odkaz:
https://doaj.org/article/95cdab2dcca64d429a1149bc75f259c8
Autor:
Qingliang Yang, Jordan C. Langston, Roman Prosniak, Samantha Pettigrew, Huaqing Zhao, Edwin Perez, Hannah Edelmann, Nadia Mansoor, Carmen Merali, Salim Merali, Nathaniel Marchetti, Balabhaskar Prabhakarpandian, Mohammad F. Kiani, Laurie E. Kilpatrick
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
PurposeSepsis is a clinical syndrome defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is a highly heterogeneous syndrome with distinct phenotypes that impact immune function and response to inf
Externí odkaz:
https://doaj.org/article/4a549513b5354850bcc150fe7987e872
Autor:
Dan Liu, Jordan C. Langston, Balabhaskar Prabhakarpandian, Mohammad F. Kiani, Laurie E. Kilpatrick
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2024)
Sepsis is a global health concern accounting for more than 1 in 5 deaths worldwide. Sepsis is now defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis can develop from bacterial (gram negative or g
Externí odkaz:
https://doaj.org/article/2075bf0ecf0a44f586a6623f3f920686
Publikováno v:
Shock. 59:224-231
Sepsis is a major health issue and a leading cause of death in hospitals globally. The treatment of sepsis is largely supportive and there are no therapeutics available that target the underlying pathophysiology of the disease. The development of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d74d34269cd4660e465ea751498454
https://doi.org/10.1097/shk.0000000000002047
https://doi.org/10.1097/shk.0000000000002047
Autor:
Qingliang Yang, Harshani Wijerathne, Jordan C. Langston, Mohammad F. Kiani, Laurie E. Kilpatrick
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7770 (2021)
The endothelium is the inner layer of all blood vessels and it regulates hemostasis. It also plays an active role in the regulation of the systemic inflammatory response. Systemic inflammatory disease often results in alterations in vascular endothel
Externí odkaz:
https://doaj.org/article/c34f57b236214d4ba7a530a9d97e4d56
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1498 (2019)
Protein Kinase C (PKC) is a family composed of phospholipid-dependent serine/threonine kinases that are master regulators of inflammatory signaling. The activity of different PKCs is context-sensitive and these kinases can be positive or negative reg
Externí odkaz:
https://doaj.org/article/73b782b14608499e8bfe71a6e07cd95f
Autor:
Mohammad F. Kiani, Laurie E. Kilpatrick, Balabhaskar Prabhakarpandian, Yuan Tang, Jordan C. Langston, Qingliang Yang
Publikováno v:
Journal of Visualized Experiments.
Leukocyte-endothelial cell interactions play an important role in inflammatory diseases such as sepsis. During inflammation, excessive migration of activated leukocytes across the vascular endothelium into key organs can lead to organ failure. A phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b27dca69aaf20ad72a4253dbbbca95
https://doi.org/10.3791/63312-v
https://doi.org/10.3791/63312-v
Autor:
Kimberly Guglielmo, Shuang Sun, Satya P. Kunapuli, Mohammad F. Kiani, Akruti Patel, Laurie E. Kilpatrick, Jordan C. Langston, Elisabetta Liverani, Alex Engelmann, Yuan Tang, Fariborz Soroush
Publikováno v:
Shock
Background Neutrophil dysfunction plays an important role in inflammation-induced tissue injury. Previously, we identified protein kinase C-δ (PKCδ) as a critical controller of neutrophil activation and trafficking but how PKCδ is regulated in inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d485fc67f229ee42a70fb1cc16c2a5b1
https://doi.org/10.1097/shk.0000000000001247
https://doi.org/10.1097/shk.0000000000001247
Molecular Framework of Mouse Endothelial Cell Dysfunction during Inflammation: A Proteomics Approach
Autor:
Michael T. Rossi, Jordan C. Langston, Narender Singh, Carmen Merali, Qingliang Yang, Salim Merali, Balabhaskar Prabhakarpandian, Laurie E. Kilpatrick, Mohammad F. Kiani
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8399
A key aspect of cytokine-induced changes as observed in sepsis is the dysregulated activation of endothelial cells (ECs), initiating a cascade of inflammatory signaling leading to leukocyte adhesion/migration and organ damage. The therapeutic targeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8c70b0e50a0843e6469c39ce7b091d
https://doi.org/10.3390/ijms23158399
https://doi.org/10.3390/ijms23158399
Autor:
Mohammad F. Kiani, Harshani Wijerathne, Qingliang Yang, Jordan C. Langston, Laurie E. Kilpatrick
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7770, p 7770 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 7770, p 7770 (2021)
The endothelium is the inner layer of all blood vessels and it regulates hemostasis. It also plays an active role in the regulation of the systemic inflammatory response. Systemic inflammatory disease often results in alterations in vascular endothel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb67771ac85379694f75b6f8dad73d5
https://pubmed.ncbi.nlm.nih.gov/34360536
https://pubmed.ncbi.nlm.nih.gov/34360536