Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Jordan Tang"'
Autor:
Daniel Zaki, MS, Lohrasb R. Sayadi, MD, Faris Halaseh, BS, Jordan Tang, BS, Mary E. Ziegler, MD, PhD, Nawal Khan, MD, Alan D. Widgerow, MBBCh, MMed, FCS, FACS
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 9, Iss 10S, Pp 129-129 (2021)
Externí odkaz:
https://doaj.org/article/bd572c48058c4216bd2d891f7e24f8cf
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 87:502-511
Cardosin A is an aspartic protease present in large amount in the pistils of cardoon flowers. This protease is known to contain an -Arg-Gly-Asp- (RGD) motif located on the molecular surface. In this study, we found that isolated recombinant cardosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410a358cc539cf809c4b9e29f8a56305
https://doi.org/10.1002/prot.25672
https://doi.org/10.1002/prot.25672
Autor:
Andrew D. Mesecar, Emilio L. Cárdenas, Deborah Downs, Kanury V. S. Rao, Yu-Chen Yen, Xiangping Huang, Jordan Tang, Arun K. Ghosh, Bhavanam Sekhara Reddy
Publikováno v:
Chemical Science. 7:3117-3122
Design, synthesis and evaluation of very potent and selective β-secretase 2 (memapsin 1, BACE 2) inhibitors are described. The inhibitors were designed specifically to interact with the S2′-site of β-secretase 2 to provide >170000-fold selectivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573b8d66f02273c2c3c567ed0e16a2b0
https://doi.org/10.1039/c5sc03718b
https://doi.org/10.1039/c5sc03718b
Autor:
Emma K. Lendy, Bhavanam Sekhara Reddy, Satish Kovela, Emilio L. Cárdenas, Andrew D. Mesecar, Yu-Chen Yen, Margherita Brindisi, Xiangping Huang, Jordan Tang, Arun K. Ghosh, Deborah Downs, Kalapala Venketeswara Rao
Publikováno v:
ChemMedChem. 14(5)
Herein we present the design, synthesis, and biological evaluation of potent and highly selective β-secretase 2 (memapsin 1, beta-site amyloid precursor protein cleaving enzyme 2, or BACE 2) inhibitors. BACE2 has been recognized as an exciting new t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fba27ca172570d648b5c71e66b4c56d
https://pubmed.ncbi.nlm.nih.gov/30637955
https://pubmed.ncbi.nlm.nih.gov/30637955
Autor:
Nagaswamy Kumaragurubaran, Koena Ghosh, Andrew D. Mesecar, Arun K. Ghosh, Emma K. Lendy, Jordan Tang, Margherita Brindisi, Yu-Chen Yen, Xiangping Huang
We describe the design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors containing bicyclic isoxazoline carboxamides as the P3 ligand in combination with methyl cysteine, methylsulfonylalanine and Boc-amino alanine as P2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ab8582625d739744a324e7c35a80f3
http://hdl.handle.net/11588/771102
http://hdl.handle.net/11588/771102
Autor:
Andrew D. Mesecar, Thippeswamy Devasamudram, Xiao Ming Xu, Jordan Tang, Yu-Chen Yen, Xiangping Huang, Gerald Koelsch, Arun K. Ghosh, Geoffrey Bilcer, Margherita Brindisi, Hui Lei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:668-672
We describe structure-based design, synthesis and biological evaluation of a series of novel inhibitors bearing a pyrazole (compounds 3a-h ) or a thiazole moiety (compounds 4a-e) as the P3 ligand. We have also explored Boc-β-amino-L-alanine as a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ca53b6dd2a23f1f20f45eecab6420d
https://doi.org/10.1016/j.bmcl.2014.11.087
https://doi.org/10.1016/j.bmcl.2014.11.087
Publikováno v:
Current Alzheimer Research. 12:13-21
The β-secretase enzyme BACE1, which initiates the cleavage of amyloid precursor protein (APP) into the amyloid-β (Aβ) peptide, is a prime therapeutic target for Alzheimer's disease (AD). However, recent investigations using genetic animal models r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8435b27bebe51a74b287bd8855af5ba
https://doi.org/10.2174/1567205012666141218125042
https://doi.org/10.2174/1567205012666141218125042
Autor:
Andrew D. Mesecar, Emilio L. Cárdenas, Jordan Tang, Yu-Chen Yen, Margherita Brindisi, Xiangping Huang, Nagaswamy Kumaragurubaran, Jean Rene Ella-Menye, Arun K. Ghosh
We report the design and synthesis of a series of BACE1 inhibitors incorporating mono- and bicyclic 6-substituted 2-oxopiperazines as novel P1′ and P2′ ligands and isophthalamide derivative as P2-P3 ligands. Among mono-substituted 2-oxopiperazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae81974b3994c5ead563c93b995ec91
http://hdl.handle.net/11588/771128
http://hdl.handle.net/11588/771128
Autor:
Margherita Brindisi, Arun K. Ghosh, Bhavanam Sekhara Reddy, Andrew D. Mesecar, Kalapala Venketeswara Rao, Deborah Downs, Jordan Tang, Satish Kovela, Emma K. Lendy, Emilio L. Cárdenas, Yu-Chen Yen, Xiangping Huang
Publikováno v:
ChemMedChem. 14:513-513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbd9b7e06126cf58b3b66af6067e505a
https://doi.org/10.1002/cmdc.201900100
https://doi.org/10.1002/cmdc.201900100
Publikováno v:
Acta Biochimica et Biophysica Sinica. 45:613-621
Memapsin 2 (BACE1, β-secretase), a membrane aspartic protease, functions in the cleavage of the type I transmembrane protein, β-amyloid precursor protein (APP), leading to the production of amyloid β (Aβ) in the brain. Since Aβ is closely associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afadb60549e301417a953bcc794018d
https://doi.org/10.1093/abbs/gmt050
https://doi.org/10.1093/abbs/gmt050