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Review

FIRST CONTEMPORARY CHINESE COMPOSERS' FESTIVAL 1986 Kenneth Schermerhorn Jordan Tang

Autor: Bozzetti, Elmar

Publikováno v: Neue Zeitschrift für Musik (1991-), 1997 Nov 01. 158(6), 68-69.

Externí odkaz: https://www.jstor.org/stable/23986776

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Akademický článek

Improving Fat Graft Retention with Micro/Nanobubbles in Vivo

Autor: Daniel Zaki, MS, Lohrasb R. Sayadi, MD, Faris Halaseh, BS, Jordan Tang, BS, Mary E. Ziegler, MD, PhD, Nawal Khan, MD, Alan D. Widgerow, MBBCh, MMed, FCS, FACS

Publikováno v: Plastic and Reconstructive Surgery, Global Open, Vol 9, Iss 10S, Pp 129-129 (2021)

Externí odkaz: https://doaj.org/article/bd572c48058c4216bd2d891f7e24f8cf

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Cardosin A endocytosis mediated by integrin leads to lysosome leakage and apoptosis of epithelial cells

Autor: Carlos Faro, Pedro Castanheira, Hao Wu, Jordan Tang

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 87:502-511

Cardosin A is an aspartic protease present in large amount in the pistils of cardoon flowers. This protease is known to contain an -Arg-Gly-Asp- (RGD) motif located on the molecular surface. In this study, we found that isolated recombinant cardosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410a358cc539cf809c4b9e29f8a56305
https://doi.org/10.1002/prot.25672

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Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes

Autor: Andrew D. Mesecar, Emilio L. Cárdenas, Deborah Downs, Kanury V. S. Rao, Yu-Chen Yen, Xiangping Huang, Jordan Tang, Arun K. Ghosh, Bhavanam Sekhara Reddy

Publikováno v: Chemical Science. 7:3117-3122

Design, synthesis and evaluation of very potent and selective β-secretase 2 (memapsin 1, BACE 2) inhibitors are described. The inhibitors were designed specifically to interact with the S2′-site of β-secretase 2 to provide >170000-fold selectivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573b8d66f02273c2c3c567ed0e16a2b0
https://doi.org/10.1039/c5sc03718b

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Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies

Autor: Emma K. Lendy, Bhavanam Sekhara Reddy, Satish Kovela, Emilio L. Cárdenas, Andrew D. Mesecar, Yu-Chen Yen, Margherita Brindisi, Xiangping Huang, Jordan Tang, Arun K. Ghosh, Deborah Downs, Kalapala Venketeswara Rao

Publikováno v: ChemMedChem. 14(5)

Herein we present the design, synthesis, and biological evaluation of potent and highly selective β-secretase 2 (memapsin 1, beta-site amyloid precursor protein cleaving enzyme 2, or BACE 2) inhibitors. BACE2 has been recognized as an exciting new t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fba27ca172570d648b5c71e66b4c56d
https://pubmed.ncbi.nlm.nih.gov/30637955

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Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand

Autor: Nagaswamy Kumaragurubaran, Koena Ghosh, Andrew D. Mesecar, Arun K. Ghosh, Emma K. Lendy, Jordan Tang, Margherita Brindisi, Yu-Chen Yen, Xiangping Huang

We describe the design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors containing bicyclic isoxazoline carboxamides as the P3 ligand in combination with methyl cysteine, methylsulfonylalanine and Boc-amino alanine as P2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ab8582625d739744a324e7c35a80f3
http://hdl.handle.net/11588/771102

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Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand

Autor: Andrew D. Mesecar, Thippeswamy Devasamudram, Xiao Ming Xu, Jordan Tang, Yu-Chen Yen, Xiangping Huang, Gerald Koelsch, Arun K. Ghosh, Geoffrey Bilcer, Margherita Brindisi, Hui Lei

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 25:668-672

We describe structure-based design, synthesis and biological evaluation of a series of novel inhibitors bearing a pyrazole (compounds 3a-h ) or a thiazole moiety (compounds 4a-e) as the P3 ligand. We have also explored Boc-β-amino-L-alanine as a nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ca53b6dd2a23f1f20f45eecab6420d
https://doi.org/10.1016/j.bmcl.2014.11.087

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Beneficial Effects of the β-Secretase Inhibitor GRL-8234 in 5XFAD Alzheimer’s Transgenic Mice Lessen During Disease Progression

Autor: Latha Devi, Masuo Ohno, Jordan Tang

Publikováno v: Current Alzheimer Research. 12:13-21

The β-secretase enzyme BACE1, which initiates the cleavage of amyloid precursor protein (APP) into the amyloid-β (Aβ) peptide, is a prime therapeutic target for Alzheimer's disease (AD). However, recent investigations using genetic animal models r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8435b27bebe51a74b287bd8855af5ba
https://doi.org/10.2174/1567205012666141218125042

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Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1 '-P2 ' ligands

Autor: Andrew D. Mesecar, Emilio L. Cárdenas, Jordan Tang, Yu-Chen Yen, Margherita Brindisi, Xiangping Huang, Nagaswamy Kumaragurubaran, Jean Rene Ella-Menye, Arun K. Ghosh

We report the design and synthesis of a series of BACE1 inhibitors incorporating mono- and bicyclic 6-substituted 2-oxopiperazines as novel P1′ and P2′ ligands and isophthalamide derivative as P2-P3 ligands. Among mono-substituted 2-oxopiperazine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae81974b3994c5ead563c93b995ec91
http://hdl.handle.net/11588/771128

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