Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Jordan S. Fridman"'
Autor:
Ross L. Levine, Rong Fan, Franziska Michor, Thomas Radimerski, Masato Murakami, Julie Teruya-Feldstein, Jacqueline Bromberg, Jordan S. Fridman, Vincent Romanet, Jonathan J. Chen, Sachie Marubayashi, Raajit Rampal, Omar Abdel-Wahab, Efthymia Papalexi, Anna Sophia McKenney, Neha Bhagwat, Todd Hricik, Lennart Bastian, Matthew Keller, Markus Riester, Priya Koppikar, Minsuk Kwak, Maria Kleppe
Supplementary Figure 1. Pro-inflammatory cytokines are elevated in MF mice and reversed with JAK inhibitor treatment. Supplementary Figure 2. Principal component analysis of MF cells. Supplementary Figure 3. Single cell analysis of immunophenotypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0739c902c6e921c3e4e3ab17e50ad9dd
https://doi.org/10.1158/2159-8290.22530627
https://doi.org/10.1158/2159-8290.22530627
Autor:
Peggy A. Scherle, Robert C. Newton, Wenqing Yao, Jincong Zhuo, Meizhong Xu, Chunhong He, Sharon Diamond, Jason Boer, Yu Li, Richard Wynn, Elham Behshad, Jordan S. Fridman, Leslie M. Hall, Holly K. Koblish, Cindy Marando, Gengjie Yang, Qian Wang, Xiangdong Liu
PDF file - 91K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e2ac65557a6da0e73230a1e910ea93
https://doi.org/10.1158/1078-0432.22443831.v1
https://doi.org/10.1158/1078-0432.22443831.v1
Autor:
Jordan S. Fridman, Kris Vaddi, Timothy C. Burn, James D. Rodgers, Andrew P. Combs, Richard B. Sparks, Patrick Haley, Gregory Hollis, Erin Crowgey, Yanlong Li, Mary Becker-Pasha, Richard Wynn, Alex Margulis, Paul Waeltz, Jun Li, Eian Caulder, Phillip C.C. Liu
Supplementary Data from Combined Inhibition of Janus Kinase 1/2 for the Treatment of JAK2V617F-Driven Neoplasms: Selective Effects on Mutant Cells and Improvements in Measures of Disease Severity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e47b931a262ce765e455bcf760d62f8
https://doi.org/10.1158/1078-0432.22440651
https://doi.org/10.1158/1078-0432.22440651
Autor:
Peggy A. Scherle, Robert C. Newton, Wenqing Yao, Jincong Zhuo, Meizhong Xu, Chunhong He, Sharon Diamond, Jason Boer, Yu Li, Richard Wynn, Elham Behshad, Jordan S. Fridman, Leslie M. Hall, Holly K. Koblish, Cindy Marando, Gengjie Yang, Qian Wang, Xiangdong Liu
PDF file - 94K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38dc9ab0796303e073ea0830c1554ad1
https://doi.org/10.1158/1078-0432.22443834
https://doi.org/10.1158/1078-0432.22443834
Autor:
Peggy A. Scherle, Robert C. Newton, Wenqing Yao, Jincong Zhuo, Meizhong Xu, Chunhong He, Sharon Diamond, Jason Boer, Yu Li, Richard Wynn, Elham Behshad, Jordan S. Fridman, Leslie M. Hall, Holly K. Koblish, Cindy Marando, Gengjie Yang, Qian Wang, Xiangdong Liu
PDF file - 66K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a72bf8abaf13e94800645d9e3c5eb8d
https://doi.org/10.1158/1078-0432.22443828
https://doi.org/10.1158/1078-0432.22443828
Autor:
Jun Li, Margaret Favata, Jennifer A. Kelley, Eian Caulder, Beth Thomas, Xiaoming Wen, Richard B. Sparks, Ari Arvanitis, James D. Rogers, Andrew P. Combs, Kris Vaddi, Kimberly A. Solomon, Peggy A. Scherle, Robert Newton, Jordan S. Fridman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 1, Pp 28-38 (2010)
Cytokines in the bone marrow of multiple myeloma patients activate Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways in tumor cells and promote tumor growth, survival, and drug resistance. INCB16562 was dev
Externí odkaz:
https://doaj.org/article/8ff70b38f3cd4dcba837d81f78e72017
Autor:
Sharon Diamond, Kamna Katiyar, Qian Wang, Andrew P. Combs, Holly Koblish, Gengjie Yang, Jordan S. Fridman, Maryanne B. Covington, Gregory Hollis, Yanlong Li, Jun Li, Swamy Yeleswaram, Xin He, Reid Huber, Yun-Long Li, Lynn Leffet, Mark Rupar, Kathy Wang, Dana Shuey, Wenqing Yao, Leslie Hall, Maxim Soloviev, Kevin Bowman, Robert C. Newton, Mike Liu, Margaret F. Favata, Peggy Scherle, Timothy Burn, Kris Vaddi, Beth Rumberger, Song Mei, Niu Shin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 364:120-130
Phosphatidylinositol 3-kinase delta (PI3Kδ) is a critical signaling molecule in B cells and is considered a target for development of therapies against various B cell malignancies. INCB040093 is a novel PI3Kδ small-molecule inhibitor and has demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95263249a805825553343b41c10e5cf4
https://doi.org/10.1124/jpet.117.244947
https://doi.org/10.1124/jpet.117.244947
Autor:
Brian M. Glass, Padmaja Polam, Tom Emm, Kevin Bowman, Jordan S. Fridman, Holly Koblish, Richard Wynn, Michael Hansbury, Yanlong Li, Eddy W. Yue, Brian Metcalf, Michael J. Bower, Min Wei, Richard B. Sparks, Peggy Scherle, Xiangdong Liu, Andrew P. Combs, Timothy Burn, Dilip P. Modi, Brian Wayland, Qian Wang, Lynn Leffet, Brent Douty, Wenyu Zhu, Amy Takvorian, Joseph Glenn
Publikováno v:
ACS Medicinal Chemistry Letters
A data-centric medicinal chemistry approach led to the invention of a potent and selective IDO1 inhibitor 4f, INCB24360 (epacadostat). The molecular structure of INCB24360 contains several previously unknown or underutilized functional groups in drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5e3f5ea28d700b9b9ea48bc68260b0
http://europepmc.org/articles/PMC5430407
http://europepmc.org/articles/PMC5430407
Autor:
Jordan S. Fridman, Efthymia Papalexi, Maria Kleppe, Jonathan J. Chen, Raajit K. Rampal, Matthew D. Keller, Priya Koppikar, Vincent Romanet, Minsuk Kwak, Neha Bhagwat, Markus Riester, Rong Fan, Ross L. Levine, Franziska Michor, Julie Teruya-Feldstein, Todd Hricik, Omar Abdel-Wahab, Anna Sophia McKenney, Thomas Radimerski, Jacqueline Bromberg, Masato Murakami, Sachie Marubayashi, Lennart Bastian
Publikováno v:
Cancer Discovery. 5:316-331
The identification of JAK2/MPL mutations in patients with myeloproliferative neoplasms (MPN) has led to the clinical development of JAK kinase inhibitors, including ruxolitinib. Ruxolitinib reduces splenomegaly and systemic symptoms in myelofibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e73938fed3156e929907eb9f3ca391
https://doi.org/10.1158/2159-8290.cd-14-0736
https://doi.org/10.1158/2159-8290.cd-14-0736
Autor:
Beth Thomas, Gregory Hollis, Patrick J. Haley, Brian Metcalf, Kris Vaddi, Claire L. Neilan, Jack G. Shi, Paul Collier, Nancy Contel, Steven Friedman, Swamy Yeleswaram, Jordan S. Fridman, Denise Hertel, Robert Collins, Stacey Shepard, Peggy Scherle, Timothy Burn, Robert C. Newton, James D. Rodgers
Publikováno v:
Journal of Investigative Dermatology. 131:1838-1844
JAKs are required for signaling initiated by several cytokines (e.g., IL-4, IL-12, IL-23, thymic stromal lymphopoietin (TSLP), and IFNγ) implicated in the pathogenesis of inflammatory skin diseases such as psoriasis and atopic dermatitis (AD). Direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7345558e130f55ec6c48b0e14482a5
https://doi.org/10.1038/jid.2011.140
https://doi.org/10.1038/jid.2011.140