Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jordan, Waters"'
Autor:
Hualan Liu, Morgan N. Price, Robert Jordan Waters, Jayashree Ray, Hans K. Carlson, Jacob S. Lamson, Romy Chakraborty, Adam P. Arkin, Adam M. Deutschbauer
Publikováno v:
mSystems, Vol 3, Iss 1 (2018)
ABSTRACT Transposon mutagenesis coupled to next-generation sequencing (TnSeq) is a powerful approach for discovering the functions of bacterial genes. However, the development of a suitable TnSeq strategy for a given bacterium can be costly and time-
Externí odkaz:
https://doaj.org/article/404e17b3e1ea41b195351afe078dd4d5
Autor:
Harley Green, Lydia Barnes, Jolyon Matthews-Wright, Rachel Szpara, Luke Francis, Nuria S. Lima, Hollie Blaber, Carrie K. W. Wong, Alexander Seal, Charlotte S. Payne, Matthew F. Meehan, C. Elizabeth Killalea, Rohan J. Trainor, Katherine Wood, Jack M. J. Grace, Oliver Williams, Liam Cochrane, Edmund J. P. Hogarth, Katherine Louise Jones, Zoe J. Lee, Shusha Mahdy, Anna Gruszka, Lisa Morrison, Freya Taday, Leyla Jusu, Oliver King, May-Li Mackinnon, Joe Stillibrand, Daniel Buckley, Edward Cooney, Z.A. Henley, Simon J. F. Macdonald, Christina L. Long, Daniel Fu He, Craig Pike, Zoe C. Byron, Keenan M. Smith, Ian Edward David Smith, Antony M. Threadgould, Lewis Byers, Kamile Stanelyte, Hal R. I. Parke, Nick Barton, Rosa Cookson, James E. Rowedder, Andrew Nortcliffe, Aaron J. Senior, Alan Nadin, Makenzie J. Millward, Joseph Lambert, Lawrence Payne, David T. K. Brooks, Christopher Merrett, Heather A. Damian, Jordan Waters, Richard G. Chilvers
Publikováno v:
Journal of Medicinal Chemistry. 62:10402-10422
Phosphoinositide-3-kinase δ (PI3Kδ) is a critical regulator of cell growth and transformation and has been explored as a therapeutic target for a range of diseases. Through the exploration of the t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3c565e07f6df53b788d687eb5d9b250
https://doi.org/10.1021/acs.jmedchem.9b01499
https://doi.org/10.1021/acs.jmedchem.9b01499
Autor:
Adam P. Arkin, Adam M. Deutschbauer, Zuelma Esquivel, Morgan N. Price, Jacob S. Lamson, Kelly M. Wetmore, Jayashree Ray, Judy D. Wall, Yumi Suh, Hualan Liu, Jennifer V. Kuehl, Axel Visel, Hans K. Carlson, Harini Sadeeshkumar, Mark Callaghan, Grant M. Zane, Benjamin E. Rubin, Ryan A. Melnyk, James Bristow, Matthew J. Blow, Robert Jordan Waters, Romy Chakraborty
Publikováno v:
Nature. 557:503-509
One-third of all protein-coding genes from bacterial genomes cannot be annotated with a function. Here, to investigate the functions of these genes, we present genome-wide mutant fitness data from 32 diverse bacteria across dozens of growth condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::839d4a3ce3c05899d47ce505ce13cc45
https://doi.org/10.1038/s41586-018-0124-0
https://doi.org/10.1038/s41586-018-0124-0
Autor:
Lydia, Barnes, Hollie, Blaber, David T K, Brooks, Lewis, Byers, Daniel, Buckley, Zoe C, Byron, Richard G, Chilvers, Liam, Cochrane, Edward, Cooney, Heather A, Damian, Luke, Francis, Daniel, Fu He, Jack M J, Grace, Harley J, Green, Edmund J P, Hogarth, Leyla, Jusu, C Elizabeth, Killalea, Oliver, King, Joseph, Lambert, Zoe J, Lee, Nuria S, Lima, Christina L, Long, May-Li, Mackinnon, Shusha, Mahdy, Jolyon, Matthews-Wright, Makenzie J, Millward, Matthew F, Meehan, Christopher, Merrett, Lisa, Morrison, Hal R I, Parke, Charlotte, Payne, Lawrence, Payne, Craig, Pike, Alexander, Seal, Aaron J, Senior, Keenan M, Smith, Kamile, Stanelyte, Joe, Stillibrand, Rachel, Szpara, Freya F H, Taday, Antony M, Threadgould, Rohan J, Trainor, Jordan, Waters, Oliver, Williams, Carrie K W, Wong, Katherine, Wood, Nick, Barton, Anna, Gruszka, Zoe, Henley, James E, Rowedder, Rosa, Cookson, Katherine L, Jones, Alan, Nadin, Ian E, Smith, Simon J F, Macdonald, Andrew, Nortcliffe
Publikováno v:
Journal of medicinal chemistry. 62(22)
Phosphoinositide-3-kinase δ (PI3Kδ) is a critical regulator of cell growth and transformation and has been explored as a therapeutic target for a range of diseases. Through the exploration of the thienopyrimidine scaffold, we have identified a liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fdc25e5b8f8a8c4bddd4753118b0c5e
https://pubmed.ncbi.nlm.nih.gov/31647659
https://pubmed.ncbi.nlm.nih.gov/31647659
Autor:
Hans K. Carlson, Jacob S. Lamson, Morgan N. Price, Hualan Liu, Adam P. Arkin, Robert Jordan Waters, Romy Chakraborty, Jayashree Ray, Adam M. Deutschbauer
Publikováno v:
mSystems, vol 3, iss 1
Liu, H; Price, MN; Waters, RJ; Ray, J; Carlson, HK; Lamson, JS; et al.(2018). Magic pools: Parallel assessment of transposon delivery vectors in bacteria. mSystems, 3(1). doi: 10.1128/mSystems.00143-17. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/75r5966d
mSystems, Vol 3, Iss 1 (2018)
mSystems, Vol 3, Iss 1, p e00143-17 (2018)
mSystems
Liu, H; Price, MN; Waters, RJ; Ray, J; Carlson, HK; Lamson, JS; et al.(2018). Magic pools: Parallel assessment of transposon delivery vectors in bacteria. mSystems, 3(1). doi: 10.1128/mSystems.00143-17. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/75r5966d
mSystems, Vol 3, Iss 1 (2018)
mSystems, Vol 3, Iss 1, p e00143-17 (2018)
mSystems
Molecular genetics is indispensable for interrogating the physiology of bacteria. However, the development of a functional genetic system for any given bacterium can be time-consuming. Here, we present a streamlined approach for identifying an effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac7c303fd3609c2149cde9fc5bf1f58
https://escholarship.org/uc/item/75r5966d
https://escholarship.org/uc/item/75r5966d
Autor:
Tonia L. Mehlhorn, Andrea M. Rocha, W. Andrew Lancaster, Brian J. Vaccaro, Angelica Pettenato, Adam P. Arkin, Ryan A. Melnyk, Michael P. Thorgersen, Adam M. Deutschbauer, Farris L. Poole, R. Jordan Waters, Terry C. Hazen, Jayashree Ray, Michael W. W. Adams, Romy Chakraborty
Publikováno v:
Thorgersen, MP; Lancaster, WA; Vaccaro, BJ; Poole, FL; Rocha, AM; Mehlhorn, T; et al.(2015). Molybdenum availability is key to nitrate removal in contaminated groundwater environments. Applied and Environmental Microbiology, 81(15), 4976-4983. doi: 10.1128/AEM.00917-15. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/4cq3m6r3
Applied and environmental microbiology, vol 81, iss 15
Applied and environmental microbiology, vol 81, iss 15
The concentrations of molybdenum (Mo) and 25 other metals were measured in groundwater samples from 80 wells on the Oak Ridge Reservation (ORR) (Oak Ridge, TN), many of which are contaminated with nitrate, as well as uranium and various other metals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac86b9f769dc8ad61554412c3779350
https://doi.org/10.1128/aem.00917-15
https://doi.org/10.1128/aem.00917-15
Autor:
Meghan E. Feltcher, Rex R. Malmstrom, Jeffery L. Dangl, Gaoyan Wang, Adam M. Deutschbauer, Meredith McDonald, Benjamin J. Cole, Kelly M. Wetmore, Axel Visel, Sabah Ul-Hasan, Elizabeth M. Ryan, Robert Jordan Waters, Yasuo Yoshikuni, Tatiana S. Mucyn
Publikováno v:
Cole, BJ; Feltcher, ME; Waters, RJ; Wetmore, KM; Mucyn, TS; Ryan, EM; et al.(2017). Genome-wide identification of bacterial plant colonization genes. PLoS Biology, 15(9). doi: 10.1371/journal.pbio.2002860. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/2r70j8xz
PLoS Biology
PLoS biology, vol 15, iss 9
PLoS Biology, Vol 15, Iss 9, p e2002860 (2017)
PLoS Biology
PLoS biology, vol 15, iss 9
PLoS Biology, Vol 15, Iss 9, p e2002860 (2017)
Diverse soil-resident bacteria can contribute to plant growth and health, but the molecular mechanisms enabling them to effectively colonize their plant hosts remain poorly understood. We used randomly barcoded transposon mutagenesis sequencing (RB-T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d4ad92eeb3e23976e639eabe858d00
http://www.escholarship.org/uc/item/2r70j8xz
http://www.escholarship.org/uc/item/2r70j8xz
Autor:
Robert Jordan Waters, James Bristow, Adam P. Arkin, Adam M. Deutschbauer, Kelly M. Wetmore, Harini Sadeeshkumar, Romy Chakraborty, Yumi Suh, Mark Callaghan, Jayashree Ray, Zuelma Esquivel, Ryan A. Melnyk, Jennifer V. Kuehl, Jacob S. Lamson, Morgan N. Price, Benjamin E. Rubin, Matthew J. Blow
SummaryThe function of nearly half of all protein-coding genes identified in bacterial genomes remains unknown. To systematically explore the functions of these proteins, we generated saturated transposon mutant libraries from 25 diverse bacteria and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a81e59989dd54c10267a50bc9e1424
https://doi.org/10.1101/072470
https://doi.org/10.1101/072470
Autor:
Adam M. Deutschbauer, Jayashree Ray, R. Jordan Waters, Jennifer V. Kuehl, Morgan N. Price, Jiawen Huang, Romy Chakraborty, Adam P. Arkin, Jeffrey M. Skerker
Publikováno v:
Genome Announcements
Cupriavidus basilensis 4G11 was isolated from groundwater at the Oak Ridge Field Research Center (FRC) site. Here, we report the complete genome sequence and annotation of Cupriavidus basilensis 4G11. The genome contains 8,421,483 bp, 7,661 predicted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92cb87b0221471566dff4b7d96b30811
https://doi.org/10.1128/genomea.00322-15
https://doi.org/10.1128/genomea.00322-15
Autor:
Gareth Butland, Robert Jordan Waters, Adam P. Arkin, Cindi A. Hoover, Morgan N. Price, Jennifer He, Kelly M. Wetmore, Adam M. Deutschbauer, Matthew J. Blow, James Bristow, Jacob S. Lamson
Publikováno v:
mBio, vol 6, iss 3
mBio, Vol 6, Iss 3 (2015)
mBio
Wetmore, KM; Price, MN; Waters, RJ; Lamson, JS; He, J; Hoover, CA; et al.(2015). Rapid quantification of mutant fitness in diverse bacteria by sequencing randomly bar-coded transposons. mBio, 6(3), 1-15. doi: 10.1128/mBio.00306-15. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/3h61s71h
mBio, Vol 6, Iss 3 (2015)
mBio
Wetmore, KM; Price, MN; Waters, RJ; Lamson, JS; He, J; Hoover, CA; et al.(2015). Rapid quantification of mutant fitness in diverse bacteria by sequencing randomly bar-coded transposons. mBio, 6(3), 1-15. doi: 10.1128/mBio.00306-15. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/3h61s71h
Transposon mutagenesis with next-generation sequencing (TnSeq) is a powerful approach to annotate gene function in bacteria, but existing protocols for TnSeq require laborious preparation of every sample before sequencing. Thus, the existing protocol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f559c808c53d859a5a2e6efd0b7338b
https://escholarship.org/uc/item/3h61s71h
https://escholarship.org/uc/item/3h61s71h