Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren’s Syndrome

Autor: Maria Herrala, Soile Turunen, Kati Hanhineva, Marko Lehtonen, Jopi J. W. Mikkonen, Hubertus Seitsalo, Reijo Lappalainen, Leo Tjäderhane, Raija K. Niemelä, Tuula Salo, Sami Myllymaa, Arja M. Kullaa, Olli Kärkkäinen

Publikováno v: Metabolites, Vol 11, Iss 9, p 595 (2021)

Saliva is a complex oral fluid, and plays a major role in oral health. Primary Sjögren’s syndrome (pSS), as an autoimmune disease that typically causes hyposalivation. In the present study, salivary metabolites were studied from stimulated saliva

Externí odkaz: https://doaj.org/article/6319bc642196472282eb43931ea858e5

Irradiation Induced Biochemical Changes in Human Mandibular Bone: A Raman Spectroscopic Study

Autor: Sridhar Reddy Padala, Dimple Saikia, Jopi J. W. Mikkonen, Emilia Uurasjärvi, Hannah Dekker, Engelbert A. J. M. Schulten, Nathalie Bravenboer, Arto Koistinen, Amrita Chauhan, Surya P. Singh, Arja M. Kullaa

Publikováno v: Applied Spectroscopy, 76(10), 1165-1173. Society for Applied Spectroscopy
Applied Spectroscopy, 76(10), 1165-1173. SAGE PUBLICATIONS INC
Reddy Padala, S, Saikia, D, Mikkonen, J J W, Uurasjärvi, E, Dekker, H, Schulten, E A J M, Bravenboer, N, Koistinen, A, Chauhan, A, Singh, S P & Kullaa, A M 2022, ' Irradiation Induced Biochemical Changes in Human Mandibular Bone : A Raman Spectroscopic Study ', Applied Spectroscopy, vol. 76, no. 10, pp. 1165-1173 . https://doi.org/10.1177/00037028221109244

Understanding the biochemical changes in irradiated human mandible after radiotherapy of cancer patients is critical for oral rehabilitation. The underlying mechanism for radiation-associated changes in the bone at the molecular level could lead to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d24e61828d4811c48b9d0c3a3ee6841
https://research.vumc.nl/en/publications/6f039547-eb1b-4ffb-a68e-5e83303d501b

Variability of salivary metabolite levels in patients with Sjögren’s syndrome

Autor: Paula Pesonen, Sami Myllymaa, Jopi J. W. Mikkonen, Raija K. Niemelä, Tuula Salo, Arja M. Kullaa, Leo Tjäderhane, Hubertus Seitsalo, Reijo Lappalainen, Maria Herrala

Publikováno v: Journal of Oral Science. 63:22-26

Purpose To investigate inter- and intra-individual variation in the levels and outputs (concentration multiplied by salivary flow rate) of salivary metabolites in patients with primary Sjogren's syndrome (pSS). Methods A total of 56 samples of stimul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dcd9a2830bfc74515c7844519d723f
https://doi.org/10.2334/josnusd.19-0504

Irradiation affects the structural, cellular and molecular components of jawbones

Autor: Anni Palander, Hannah Dekker, Arja M. Kullaa, Sridhar Reddy P, Jopi J. W. Mikkonen, Bina Kashyap, Nathalie Bravenboer

Publikováno v: Padala, S R, Kashyap, B, Dekker, H, Mikkonen, J J W, Palander, A, Bravenboer, N & Kullaa, A M 2022, ' Irradiation affects the structural, cellular and molecular components of jawbones ', International Journal of Radiation Biology, vol. 98, no. 2, pp. 136-147 . https://doi.org/10.1080/09553002.2022.2013568
International Journal of Radiation Biology, 98(2), 136-147. TAYLOR & FRANCIS LTD
Padala, S R, Kashyap, B, Dekker, H, Mikkonen, J J W, Palander, A, Bravenboer, N & Kullaa, A M 2021, ' Irradiation affects the structural, cellular and molecular components of jawbones ', International Journal of Radiation Biology . https://doi.org/10.1080/09553002.2022.2013568

Purpose: Emerging evidence shows that changes in the bone and its microenvironment following radiotherapy are associated with either an inhibition or a state of low bone formation. Ionizing radiation is damaging to the jawbone as it increases the com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7810046f6f76556fab8c4f79abbee69a
https://doi.org/10.1080/09553002.2022.2013568

Acid-etching technique of non-decalcified bone samples for visualizing osteocyte-lacuno-canalicular network using scanning electron microscope

Autor: Chris M. ten Bruggenkate, Arja M. Kullaa, Arto Koistinen, Tiina Lampi, Hannah Dekker, E.A.J.M. Schulten, Jopi J. W. Mikkonen

Publikováno v: Lampi, T, Dekker, H, Ten Bruggenkate, C M, Schulten, E A J M, Mikkonen, J J W, Koistinen, A & Kullaa, A M 2018, ' Acid-etching technique of non-decalcified bone samples for visualizing osteocyte-lacuno-canalicular network using scanning electron microscope ', Ultrastructural Pathology, vol. 42, no. 1, pp. 74-79 . https://doi.org/10.1080/01913123.2017.1384418
Ultrastructural pathology, 42(1), 74-79. Informa Healthcare
Lampi, T, Dekker, H, ten Bruggenkate, C M, Schulten, E A J M, Mikkonen, J J W, Koistinen, A & Kullaa, A M 2018, ' Acid-etching technique of non-decalcified bone samples for visualizing osteocyte-lacuno-canalicular network using scanning electron microscope ', Ultrastructural pathology, vol. 42, no. 1, pp. 74-79 . https://doi.org/10.1080/01913123.2017.1384418
Ultrastructural Pathology, 42(1), 74-79. Informa Healthcare

The aim of this study was to define the acid-etching technique for bone samples embedded in polymethyl metacrylate (PMMA) in order to visualize the osteocyte lacuno-canalicular network (LCN) for scanning electron microscopy (SEM). Human jaw bone tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df41e842a2e6b5c98d75a783f7fc06fd
https://doi.org/10.1080/01913123.2017.1384418