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Discovery of HLA-E-Presented Epitopes: MHC-E/Peptide Binding and T-Cell Recognition

Autor: Ruibal, P, Franken, KLMC, van Meijgaarden, KE, Walters, LC, McMichael, AJ, Gillespie, GM, Joosten, SA, Ottenhoff, THM

Publikováno v: Methods in Molecular Biology ISBN: 9781071627112

Understanding the interactions involved during the immunological synapse between peptide, HLA-E molecules, and TCR is crucial to effectively target protective HLA-E-restricted T-cell responses in humans. Here we describe three techniques based on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57efd9c797ef29f810c9c9b9889910ae
https://pubmed.ncbi.nlm.nih.gov/36087196

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Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19

Autor: Pongracz, T, Nouta, J, Wang, Wenjun, van, Meijgaarden KE, Linty, F, Vidarsson, G, Joosten, SA, Ottenhoff, THM, Hokke, CH, de, Vries JJC, Arbous, SM, Roukens, AHE, groups, COVID-19, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

Publikováno v: eBioMedicine
EBioMedicine, 78. ELSEVIER
EBioMedicine, 78:103957. Elsevier BV
EBioMedicine, 78(April 01). Elsevier BV

BackgroundImmunoglobulin G1 (IgG1) effector functions are impacted by the structure of fragment crystallizable (Fc) tail-linked N-glycans. Low fucosylation levels on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d085ac87507a506f709b738dd27c95

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RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Autor: Penn-Nicholson, A, Mbandi, SK, Thompson, E, Mendelsohn, SC, Suliman, S, Chegou, NN, Malherbe, ST, Darboe, F, Erasmus, M, Hanekom, WA, Bilek, N, Fisher, M, Kaufmann, SHE, Winter, J, Murphy, M, Wood, R, Morrow, C, Van Rhijn, I, Moody, B, Murray, M, Andrade, BB, Sterling, TR, Sutherland, J, Naidoo, K, Padayatchi, N, Walzl, G, Hatherill, M, Zak, D, Scriba, TJ, Kafaar, F, Workman, L, Mulenga, H, Hughes, EJ, Xasa, O, Veldsman, A, Cloete, Y, Abrahams, D, Moyo, S, Gelderbloem, S, Tameris, M, Geldenhuys, H, Ehrlich, R, Verver, S, Geiter, L, Black, GF, van der Spuy, G, Stanley, K, Kriel, M, Du Plessis, N, Nene, N, Roberts, T, Kleynhans, L, Gutschmidt, A, Smith, B, Loxton, AG, Tromp, G, Tabb, D, Ottenhoff, THM, Klein, MR, Haks, MC, Franken, KLMC, Geluk, A, van Meijgaarden, KE, Joosten, SA, Boom, WH, Thiel, B, Mayanja-Kizza, H, Joloba, M, Zalwango, S, Nsereko, M, Okwera, B, Kisingo, H, Parida, SK, Golinski, R, Maertzdorf, J, Weiner, J, Jacobson, M, Dockrell, H, Smith, S, Gorak-Stolinska, P, Hur, YG, Lalor, M, Lee, JS, Crampin, AC, French, N, Ngwira, B, Ben-Smith, A, Watkins, K, Ambrose, L, Simukonda, F, Mvula, H, Chilongo, F, Saul, J, Branson, K, Mahomed, H, Downing, K

Publikováno v: Scientific reports
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, 10(1):8629. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-21 (2020)
Scientific Reports, 10(1). NATURE PUBLISHING GROUP
Scientific Reports, 10(1). NLM (Medline)
Scientific Reports, 10(1):8629. Nature Publishing Group

Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature, RISK6, for multiple applications: identifying individuals at risk of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72b4b335a138b78e75f4f968504b069
https://researchonline.lshtm.ac.uk/id/eprint/4656993/1/s41598-020-65043-8.pdf

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