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Autor:
Joost vanHaasteren, Stephen L. Hart, Aristides D. Tagalakis, David McCarthy, Luca Rosa, Mustafa M. Munye, Ahmad Aldossary
Publikováno v:
Molecular Therapy. 24:S11
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis conductance regulator (CFTR) gene, which encodes for a chloride channel. Loss of CFTR upregulates the epithelial sodium channel (ENaC) causing hyperabsorption of sodium, reducing the