Low-dose cyclophosphamide depletes circulating naïve and activated regulatory T cells in malignant pleural mesothelioma patients synergistically treated with dendritic cell-based immunotherapy

Autor: Lisanne Noordam, Margaretha E.H. Kaijen, Koen Bezemer, Robin Cornelissen, Lex A.P.W.M. Maat, Henk C. Hoogsteden, Joachim G.J.V. Aerts, Rudi W. Hendriks, Joost P.J.J Hegmans, Heleen Vroman

Publikováno v: OncoImmunology, Vol 7, Iss 12 (2018)

Rationale: Regulatory T cells (Treg) play a pivotal role in the immunosuppressive tumor micro-environment in cancer, including mesothelioma. Recently, the combination of autologous tumor lysate-pulsed dendritic cells (DC) and metronomic cyclophospham

Externí odkaz: https://doaj.org/article/5511702cf6784ad3925ba874ceb4f0f3

Supplementary Data from Autologous Dendritic Cells Pulsed with Allogeneic Tumor Cell Lysate in Mesothelioma: From Mouse to Human

Autor: Henk C. Hoogsteden, Joost P.J.J. Hegmans, Rudi W. Hendriks, Arnold G. Vulto, Bronno van der Holt, Eric Braakman, Cynthia Waasdorp, Ferry A.L.M. Eskens, André Kunert, Niken M. Mahaweni, Cor H. van der Leest, Koen Bezemer, Margaretha E.H. Kaijen-Lambers, Robin Cornelissen, Pauline L. de Goeje, Joachim G.J.V. Aerts

Supplementary Material and Methods: Preparation of allogeneic tumor lysate Figure S1: CD8 T-cells from DC immunotherapy treated mice show tumor cell killing capacity Figure S2: Progression free survival of patients in the first-in-human clinical stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f97b6c8e3225f046d755e41fbb18e34
https://doi.org/10.1158/1078-0432.22465283.v1

Autologous Dendritic Cells Pulsed with Allogeneic Tumor Cell Lysate in Mesothelioma: From Mouse to Human

Autor: Bronno van der Holt, Pauline L. de Goeje, Cynthia Waasdorp, Eric Braakman, Joachim G.J.V. Aerts, Andre Kunert, Rudi W. Hendriks, Henk C. Hoogsteden, Margaretha E.H. Kaijen-Lambers, Joost P.J.J. Hegmans, Robin Cornelissen, Koen Bezemer, Ferry A.L.M. Eskens, Cor van der Leest, Niken M. Mahaweni, Arnold G. Vulto

Publikováno v: Clinical Cancer Research, 24(4), 766-776. American Association for Cancer Research Inc.

Purpose: Mesothelioma has been regarded as a nonimmunogenic tumor, which is also shown by the low response rates to treatments targeting the PD-1/PD-L1 axis. Previously, we demonstrated that autologous tumor lysate–pulsed dendritic cell (DC) immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e2e871d1f3d2556c2422b6bb11a232
https://doi.org/10.1158/1078-0432.ccr-17-2522

Efficacy of Tumor Vaccines and Cellular Immunotherapies in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

Autor: Henk C. Hoogsteden, Floris Dammeijer, Lidia R. Arends, Joost P.J.J. Hegmans, Lysanne A. Lievense, G.D. Marijn Veerman, Joachim G.J.V. Aerts

Publikováno v: Journal of Clinical Oncology, 34(26), 3204-3212. American Society of Clinical Oncology

Purpose Programmed cell death protein-1- checkpoint blockers have recently been approved as second-line treatment for advanced non–small-cell lung cancer (NSCLC). Unfortunately, only a subgroup of patients responds and shows long-term survival to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089b0c29748f35a79b8dd72d2e87391c
https://pure.eur.nl/en/publications/61f0d600-c71b-4b38-83b2-6637d7c5aebc

Stereotactic ablative radiotherapy induces peripheral t-cell activation in patients with early-stage lung cancer

Autor: Suresh Senan, Cynthia Waasdorp, Alexander P.W.M. Maat, Margaretha E.H. Kaijen-Lambers, Rudi W. Hendriks, Koen Bezemer, Koen J. Hartemink, Joachim G.J.V. Aerts, Joost J. Nuyttens, Mark de Mol, Egbert F. Smit, Merel T B Schram, Pauline L. de Goeje, Joost P.J.J. Hegmans

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 196(9), 1224-1227. American Thoracic Society
De Goeje, P L, Smit, E F, Waasdorp, C, Schram, M T B, Kaijen-Lambers, M E H, Bezemer, K, De Mol, M, Hartemink, K J, Nuyttens, J J M E, Maat, A P W M, Hegmans, J P J J, Hendriks, R W, Senan, S & Aerts, J G J V 2017, ' Stereotactic ablative radiotherapy induces peripheral t-cell activation in patients with early-stage lung cancer ', American Journal of Respiratory and Critical Care Medicine, vol. 196, no. 9, pp. 1224-1227 . https://doi.org/10.1164/rccm.201610-2178LE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32029c5ce63f69c99a00a907275fe08
https://research.vumc.nl/en/publications/bd84b4eb-0042-48f8-a7e8-7901c0a41b8e