IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes

Autor: Cécile Apert, Ariel O. Galindo-Albarrán, Sarah Castan, Claire Detraves, Héloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Holländer, Saulius Žuklys, Jérémy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Development of Foxp3-expressing regulatory T-lymphocytes (Treg) in the thymus is controlled by signals delivered in T-cell precursors via the TCR, co-stimulatory receptors, and cytokine receptors. In absence of IL-2, IL-15 or their receptors, fewer T

Externí odkaz: https://doaj.org/article/99c45be99e5148a1b68f7c4d8d930a42

The Repertoire of Newly Developing Regulatory T Cells in the Type 1 Diabetes–Prone NOD Mouse Is Very Diverse

Autor: Olivier Joffre, Bart Haegeman, Jérémy C. Santamaria, Joost P. M. van Meerwijk, Sarah Castan, Paola Romagnoli, Ariel Galindo-Albarrán

Publikováno v: Diabetes
Diabetes, American Diabetes Association, 2021, 70 (8), pp.1729-1737. ⟨10.2337/db20-1072⟩
Diabetes, 2021, 70 (8), pp.1729-1737. ⟨10.2337/db20-1072⟩

Regulatory T lymphocytes expressing the forkhead/winged helix transcription factor Foxp3 (Treg) play a vital role in the protection of the organism from autoimmune disease and other immunopathologies. The antigen specificity of Treg plays an importan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc033f43c579b397a74202c99b665de8
https://doi.org/10.2337/db20-1072

IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes

Autor: Paola Romagnoli, Joost P. M. van Meerwijk, Cécile Apert

Publikováno v: Protein & Cell, Vol 9, Iss 4, Pp 322-332 (2017)
Protein & Cell

Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4115b085f8b894a1829d62bffbcb88a2
http://link.springer.com/article/10.1007/s13238-017-0425-3

Antigen-presenting cells and T-lymphocytes homing to the thymus shape T cell development

Autor: Jeremy C. Santamaria, Paola Romagnoli, Joost P. M. van Meerwijk, Julie Darrigues

Publikováno v: Immunology letters. 204

Hematopoietic precursors entering the thymus undergo a maturation process leading to the generation of a variety of T cell subsets that migrate to the periphery to perform their effector functions. This maturation process is strictly regulated by mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0778d796eba6ead92f480c61538b04f9
https://pubmed.ncbi.nlm.nih.gov/30308217

CD28

Autor: Yirajen, Vuddamalay, Joost P M, van Meerwijk

Publikováno v: Frontiers in Immunology

Since the rebirth of regulatory (formerly known as suppressor) T cells in the early 1990s, research in the field of immune-regulation by various T cell populations has quickly gained momentum. While T cells expressing the transcription factor Foxp3 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41d330156790ced9321df741558741ad
https://pubmed.ncbi.nlm.nih.gov/28167946