Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joost P. Bruijntjes"'
Molecular Characterization of Trimellitic Anhydride–induced Respiratory Allergy in Brown Norway Rats
Autor:
Joost P. Bruijntjes, André Boorsma, Hans Muijser, Kitty C.M. Verhoeckx, Josje H.E. Arts, Rob H. Stierum, Marijana Radonjic, Marinus Dansen, Wilbert H. M. Heijne, C. Frieke Kuper
Publikováno v:
Toxicologic pathology, 7, 36, 985-998
To contribute to the hazard identification of low molecular weight (LMW) respiratory allergens, respiratory allergy induced by trimellitic anhydride (TMA) was characterized by whole genome analysis of lung tissue and blood proteomics in Brown Norway
Autor:
André Penninks, Joost P. Bruijntjes, Niels-Christian Ganderup, M.L. de Zeeuw-Brouwer, C.F. Kuper, G.J.D. van Mierlo, M. Otto, Schijf
Publikováno v:
Clinical & Experimental Pharmacology.
Introduction: There is a growing interest in the minipig as a non-rodent species in the safety assessment of (bio) pharmaceuticals and (agro) chemicals. For (bio) pharmaceuticals the need to evaluate the potential adverse effects on the immune system
Autor:
Joost P. Bruijntjes, C. Frieke Kuper, Ine Waalkens, Andre Wolterbeek, Didima de Groot, Cor Snel, Lidy van Oostrum, Aswin Menke
Publikováno v:
Toxicologic Pathology, 2, 40, 255-260
Characteristic susceptibility to environmental and pharmaceutical exposure may occur during periods in life of marked histophysiological changes of the immune system. Perinatal development is such a period; pregnancy followed by lactation is potentia
Publikováno v:
Developmental Immunology
The histology of epithelium-free areas in the subcapsular region of the thymus was studied in Wistar rats. Lymphocytes in these areas were CD4/CD8 double-positive, TCR alpha/beta positive in low intensity, and in CD5 labeling either negative or posit
Autor:
Joop H. J. Van Nesselrooij, Victor J. Feron, Gwen M. Tillapaugh-Fay, Joost P. Bruijntjes, Annemarie van Garderen-Hoetmer
Publikováno v:
Carcinogenesis. 12:289-297
Estrogen-induced pituitary lesions in rats were studied in time-sequence experiments using magnetic resonance imaging (MRI), hormone determinations and light microscopy. The main purpose of the study was to evaluate the usefulness of MRI in compariso
Autor:
André Boorsma, C. Frieke Kuper, Josje H.E. Arts, Marcel A. Schijf, Nanne Bloksma, Joost P. Bruijntjes, Menk K. Prinsen, Rob H. Stierum
Publikováno v:
Toxicology. 246(2-3)
All LMW respiratory allergens known to date can also induce skin allergy in test animals. The question here was if in turn skin allergens can induce allergy in the respiratory tract. Respiratory allergy was tested in Th2-prone Brown Norway (BN) rats
Autor:
Ruud Woutersen, Jolanda van den Berg, Coen F. van Kreijl, Rudolf B. Beems, B.A.R. Lina, Bob Thoolen, Joost P. Bruijntjes, Jan van Benthem, Johan Monbaliu
Publikováno v:
Toxicologic pathology. 32(2)
As part of the international evaluation program coordinated by ILSI/HESI, the potential of DNA repair deficient Xpa- /- mice and the double knockout Xpa- /- .p53+ /- mice for short term carcinogenicity assays was evaluated. For comparison also wild-t
Autor:
Joost P. Bruijntjes, Ruud Woutersen, Frieke Kuper, M.J. Appel, André Penninks, Andre Wolterbeek, Geertje van Mierlo
Publikováno v:
Reproductive Toxicology. 30:232-232