Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment

Autor: Tom Houben, Tulasi Yadati, Robbin de Kruijf, Marion J. J. Gijbels, Joost J. F. P. Luiken, Marc van Zandvoort, Dimitris Kapsokalyvas, Dieter Lütjohann, Marit Westerterp, Jogchum Plat, David Leake, Ronit Shiri-Sverdlov

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Lifestyle- and genetically induced disorders related to disturbances in cholesterol metabolism have shown the detrimental impact of excessive cholesterol levels on a plethora of pathological processes such as inflammation. In this context, two-hydrox

Externí odkaz: https://doaj.org/article/bbd2929920734dc38c17c39f7b117938

Acute and Chronic Effects of Protein Kinase-D Signaling on Cardiac Energy Metabolism

Autor: Ozlenen Simsek Papur, Aomin Sun, Jan F. C. Glatz, Joost J. F. P. Luiken, Miranda Nabben

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 5 (2018)

Protein kinase-D (PKD) is increasingly recognized as a key regulatory signaling hub in cardiac glucose uptake and also a major player in the development of hypertrophy. Glucose is one of the predominant energy substrates for the heart to support cont

Externí odkaz: https://doaj.org/article/94adcf5ea1fe4bad8470cdf130210247

Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H+-ATPase Disassembly—Rescue by Specific Amino Acid Supplementation

Autor: Shujin Wang, Dietbert Neumann, B. Daan Westenbrink, Francesco Schianchi, Li-Yen Wong, Aomin Sun, Agnieszka Strzelecka, Jan F. C. Glatz, Joost J. F. P. Luiken, Miranda Nabben

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 12909
International Journal of Molecular Sciences, 23(21):12909. MDPI AG
International journal of molecular sciences, 23(21):12909. Multidisciplinary Digital Publishing Institute (MDPI)

The heart is metabolically flexible. Under physiological conditions, it mainly uses lipids and glucose as energy substrates. In uncontrolled diabetes, the heart switches towards predominant lipid utilization, which over time is detrimental to cardiac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271271f426d3b4ebb25cd7ea28570770

Phosphatidylinositol 4-kinase IIIβ mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes

Autor: Ellen Dirkx, Agnieszka Strzelecka, Jan F. C. Glatz, Shujin Wang, Miranda Nabben, Dietbert Neumann, O. Simsek Papur, Aomin Sun, Joost J. F. P. Luiken, Li-Yen Wong, T. Sips

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 78(6), 2839-2856. Springer

In the diabetic heart, long-chain fatty acid (LCFA) uptake is increased at the expense of glucose uptake. This metabolic shift ultimately leads to insulin resistance and a reduced cardiac function. Therefore, signaling kinases that mediate glucose up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c03f02376c8fc81fed59183e93ee1b
https://doi.org/10.1007/s00018-020-03669-7

CD36 (SR-B2) as a Target to Treat Lipid Overload-Induced Cardiac Dysfunction

Autor: Jan F. C. Glatz, Miranda Nabben, Joost J. F. P. Luiken

Publikováno v: Journal of Lipid and Atherosclerosis
Journal of Lipid and Atherosclerosis, Vol 9, Iss 1, Pp 66-78 (2020)

The heart faces the challenge of adjusting the rate of fatty acid uptake to match myocardial demand for energy provision at any given moment, avoiding both too low uptake rates, which could elicit an energy deficit, and too high uptake rates, which p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c687fd01a5114e7e25cb322227a008
http://europepmc.org/articles/PMC7379071