Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Joost H A Martens"'
Autor:
Harry Dolstra, Gosse J Adema, Nataschja I Ho, Lisa G M Huis in 't Veld, Jesper van Eck van der Sluijs, Branco M H Heuts, Maaike W G Looman, Esther D Kers-Rebel, Koen van den Dries, Joost H A Martens, Willemijn Hobo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background Adjuvants are key for effective vaccination against cancer and chronic infectious diseases. Saponin-based adjuvants (SBAs) are unique among adjuvants in their ability to induce robust cell-mediated immune responses in addition to antibody
Externí odkaz:
https://doaj.org/article/c01dcb8743c64477b7c1e9befc909182
Autor:
Esther Tijchon, Guoqiang Yi, Amit Mandoli, Jos G A Smits, Francesco Ferrari, Branco M H Heuts, Falco Wijnen, Bowon Kim, Eva M Janssen-Megens, Jan Jacob Schuringa, Joost H A Martens
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226435 (2019)
Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect normal hematopoiesis. The analysis of human AMLs has mostly been performed using end-point materials, such as cell lines and patient derived AMLs that also carry additio
Externí odkaz:
https://doaj.org/article/c2d8cbfea6314d7495286f1c3efb457d
Autor:
Marco Carretta, Annet Z Brouwers-Vos, Matthieu Bosman, Sarah J Horton, Joost H A Martens, Edo Vellenga, Jan Jacob Schuringa
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189102 (2017)
In the present work we aimed to identify targetable signaling networks in human MLL-AF9 leukemias. We show that MLL-AF9 cells critically depend on FLT3-ligand induced pathways as well as on BRD3/4 for their survival. We evaluated the in vitro and in
Externí odkaz:
https://doaj.org/article/b1805072dfc34bbfa2edac39950bafeb
Autor:
Jeron Venhuizen, Maaike G. J. M. van Bergen, Saskia M. Bergevoet, Daan Gilissen, Cornelia G. Spruijt, Laura Wingens, Emile van den Akker, Michiel Vermeulen, Joop H. Jansen, Joost H. A. Martens, Bert A. van der Reijden
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract The transcription factor Growth Factor Independence 1B (GFI1B) recruits Lysine Specific Demethylase 1 A (LSD1/KDM1A) to stimulate gene programs relevant for megakaryocyte and platelet biology. Inherited pathogenic GFI1B variants result in th
Externí odkaz:
https://doaj.org/article/558fcbd9db0c4afb9f0c4bb2090de2b9
Autor:
Nunzio Del Gaudio, Antonella Di Costanzo, Ning Qing Liu, Lidio Conte, Carmela Dell’Aversana, Guglielmo Bove, Rosaria Benedetti, Liliana Montella, Fortunato Ciardiello, Vincenzo Carafa, Concetta Ambrosino, Valeria Tucci, Mariarosaria Conte, Joost H. A. Martens, Hendrik G. Stunnenberg, Angela Nebbioso, Lucia Altucci
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovered chromatin readers i
Externí odkaz:
https://doaj.org/article/07529a4a602742c3a53ad8261632a83c
Autor:
Sandra Cantilena, Luca Gasparoli, Deepali Pal, Olaf Heidenreich, Jan‐Henning Klusmann, Joost H. A. Martens, Alexandre Faille, Alan J. Warren, Mawar Karsa, Ruby Pandher, Klaartje Somers, Owen Williams, Jasper de Boer
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 6, Pp n/a-n/a (2022)
Abstract Background Improving the poor prognosis of infant leukaemias remains an unmet clinical need. This disease is a prototypical fusion oncoprotein‐driven paediatric cancer, with MLL (KMT2A)‐fusions present in most cases. Direct targeting of
Externí odkaz:
https://doaj.org/article/1c1567bc09014df8bcc740417102afeb
Autor:
Olivier B. Bakker, Aarón D. Ramírez-Sánchez, Zuzanna A. Borek, Niek de Klein, Yang Li, Rutger Modderman, Yvonne Kooy-Winkelaar, Marie K. Johannesen, Filomena Matarese, Joost H. A. Martens, Vinod Kumar, Jeroen van Bergen, Shuo-Wang Qiao, Knut E. A. Lundin, Ludvig M. Sollid, Frits Koning, Cisca Wijmenga, Sebo Withoff, Iris H. Jonkers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Celiac disease is an auto-immune disease in which an immune response to dietary gluten leads to inflammation and subsequent atrophy of small intestinal villi, causing severe bowel discomfort and malabsorption of nutrients. The major instigat
Externí odkaz:
https://doaj.org/article/66b9019aaac7432d846ad8c14c396c51
Autor:
Lotte E. Tholen, Femke Latta, Joost H. A. Martens, Joost G. J. Hoenderop, Jeroen H. F. de Baaij
Publikováno v:
American Journal of Physiology : Renal Physiology, 324, F211-F224
American Journal of Physiology : Renal Physiology, 324, 2, pp. F211-F224
American Journal of Physiology : Renal Physiology, 324, 2, pp. F211-F224
Genetic defects in transcription factor hepatocyte nuclear factor (HNF)1β cause a heterogeneous disease characterized by electrolyte disturbances, kidney cysts, and diabetes. By combining RNA-sequencing and HNF1β chromatin immunoprecipitation-seque
Autor:
Branco Heuts, Saioa Arza-Apalategi, Sinna Alkema, Esther Tijchon, Laura Jussen, Saskia Bergevoet, Bert van der Reijden, Joost H. A. Martens
A t(9;11)(p22;q23) translocation produces the MLL-AF9 fusion protein, which is found in up to 25% of de novo AML cases in children. Despite major advances, obtaining a comprehensive understanding of context-dependent MLL-AF9-mediated gene programs du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af6664e2950a51ae1d66deb9b6d711c1
https://doi.org/10.21203/rs.3.rs-2521405/v1
https://doi.org/10.21203/rs.3.rs-2521405/v1
Autor:
Büsra Geckin, Martijn Zoodsma, Gizem Kilic, Priya A. Debisarun, Srabanti Rakshit, Vasista Adiga, Asma Ahmed, Chaitra Parthiban, Nirutha Chetan Kumar, George D’Souza, Marijke P. Baltissen, Joost H. A. Martens, Jorge Domínguez-Andrés, Yang Li, Annapurna Vyakarnam, Mihai G. Netea
Publikováno v:
Microbiology spectrum, 11, 1-12
Microbiology spectrum, 11, 2, pp. 1-12
Microbiology spectrum, 11, 2, pp. 1-12
In this study, we assessed the differences in immune responses in individuals from India and Europe. This aspect is of great relevance, because of the described differences in morbidity and mortality between India and Europe during the pandemic.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07e9518f99995718b78648252f3bef9
http://hdl.handle.net/2066/291030
http://hdl.handle.net/2066/291030