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Akademický článek

CHOmics: A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines.

Autor: Dongdong Lin, Hima B Yalamanchili, Xinmin Zhang, Nathan E Lewis, Christina S Alves, Joost Groot, Johnny Arnsdorf, Sara P Bjørn, Tune Wulff, Bjørn G Voldborg, Yizhou Zhou, Baohong Zhang

Publikováno v: PLoS Computational Biology, Vol 16, Iss 12, p e1008498 (2020)

Chinese hamster ovary (CHO) cell lines are widely used in industry for biological drug production. During cell culture development, considerable effort is invested to understand the factors that greatly impact cell growth, specific productivity and p

Externí odkaz: https://doaj.org/article/849744a569d14e8f84cf44db421cb425

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Benchmarking and optimization of a high-throughput sequencing based method for transgene sequence variant analysis in biotherapeutic cell line development

Autor: Christina S. Alves, Chongfeng Xu, Yizhou Zhou, Baohong Zhang, Justin Crisafulli, Eric Marshall, Patrick Cullen, Fergal Casey, Thomas M. Carlile, Chao Sun, Dongdong Lin, Joost Groot

Publikováno v: Biotechnology journalREFERENCES. 16(8)

In recent years High-Throughput Sequencing (HTS) based methods to detect mutations in biotherapeutic transgene products have become a key quality step deployed during the development of manufacturing cell line clones. Previously we reported on a high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7ec4f571cfa5cc295a3e29b246dc19
https://pubmed.ncbi.nlm.nih.gov/34018310

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SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures

Autor: Melissa Bennion, Justin W. Nicholatos, Andreas Weihofen, Joost Groot, Thomas M. Carlile, Isin Dalkilic-Liddle, Lori Hrdlicka, David T. Tran, Shekhar Dhokai, Warren D. Hirst

Publikováno v: eNeuro

Here we report the independent discovery and validation of Stearoyl-CoA desaturase (SCD) as a modulator of alpha-synuclein (αSyn) induced pathology and toxicity in cell-based Parkinson’s Disease models (PD). We identified SCD as top altered gene f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113ae30442d1325f7906cb63d467e0e5
https://pubmed.ncbi.nlm.nih.gov/34301719

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CHOmics: A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

Autor: Nathan E. Lewis, Dongdong Lin, Hima Yalamanchili, Christina S. Alves, Johnny Arnsdorf, Yizhou Zhou, Baohong Zhang, Tune Wulff, Xinmin Zhang, Sara Peterson Bjørn, Bjørn G. Voldborg, Joost Groot

Publikováno v: PLoS computational biology, vol 16, iss 12
PLoS Computational Biology
Lin, D, Yalamanchili, H B, Zhang, X, Lewis, N E, Alves, C S, Groot, J, Arnsdorf, J, Bjørn, S P, Wulff, T, Voldborg, B G, Zhou, Y & Zhang, B 2020, ' CHOmics : A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines ', PLOS Computational Biology, vol. 16, no. 12, e1008498 . https://doi.org/10.1371/journal.pcbi.1008498
PLoS Computational Biology, Vol 16, Iss 12, p e1008498 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce535c630d3b5c1781f87633a7e721c
https://escholarship.org/uc/item/7kn8h9gx

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The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease of aging, affecting approximately 10 million patients worldwide with no approved therapies to modify progression of disease. Further understanding of the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb3ec65a00961d85ce63c47c5a6b5d9
https://doi.org/10.1073/pnas.2006476118

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Benchmarking and optimization of a Next Generation Sequencing based method for transgene Sequence Variant Analysis in Biotherapeutic Cell Line Development

Autor: Chao Sun, Justin Crisafulli, Dongdong Lin, Baohong Zhang, Yizhou Zhou, Patrick Cullen, Eric Marshall, Joost Groot, Thomas M. Carlile, Christina S. Alves, Fergal Casey, Chongfeng Xu

In recent years Next-Generation Sequencing (NGS) based methods to detect mutations in biotherapeutic transgene products have become a key quality step deployed during the development of manufacturing cell line clones. Previously we reported on a high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::673eb23f17e8240401d01b49c93bb93b
https://doi.org/10.22541/au.160397369.95796795/v1

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Genetic mutation analysis at early stages of cell line development using next generation sequencing

Autor: Mei Liu, Samantha Swahn, Helen McLaughlin, Chapman Wright, Scott Estes, Chongfeng Xu, Joost Groot, Chao Sun, Eric Zheng

Publikováno v: Biotechnology Progress. 32:813-817

A central goal for most biopharmaceutical companies is to reduce the development timeline to reach clinical proof of concept. This objective requires the development of tools that ensure the quality of biotherapeutic material destined for the clinic.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6828943d6d0b40e6e897e86371b14b
https://doi.org/10.1002/btpr.2263

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Multiplex growth rate phenotyping of synthetic mutants in selection to engineer glucose and xylose co-utilization in Escherichia coli

Autor: Sidney C. Cepress‐Mclean, Joost Groot, Ryan T. Gill, Rob Knight, Adam Robbins-Pianka

Publikováno v: Biotechnology and bioengineering. 114(4)

Engineering the simultaneous consumption of glucose and xylose sugars is critical to enable the sustainable production of biofuels from lignocellulosic biomass. In most major industrial microorganisms glucose completely inhibits the uptake of xylose,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfbc89526dc382184c923ccbc2fd7d41
https://pubmed.ncbi.nlm.nih.gov/27861733

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