Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Joost C. M. Holthuis"'
Autor:
Helene Jahn, Ladislav Bartoš, Grace I. Dearden, Jeremy S. Dittman, Joost C. M. Holthuis, Robert Vácha, Anant K. Menon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Mitochondria are double-membrane-bounded organelles that depend critically on phospholipids supplied by the endoplasmic reticulum. These lipids must cross the outer membrane to support mitochondrial function, but how they do this is unclear.
Externí odkaz:
https://doaj.org/article/80090a11e13246b496e3a818de0be8af
Autor:
Patrick Niekamp, Felix Scharte, Tolulope Sokoya, Laura Vittadello, Yeongho Kim, Yongqiang Deng, Elisabeth Südhoff, Angelika Hilderink, Mirco Imlau, Christopher J. Clarke, Michael Hensel, Christopher G. Burd, Joost C. M. Holthuis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Activation of ESCRT prevents potentially lethal outcomes of minor perturbations in lysosomal integrity. Here authors show that Ca2 + -activated scrambling of sphingomyelin and its cytosolic turnover drives lysosomal repair independently of ESCRT.
Externí odkaz:
https://doaj.org/article/8782aaf4d7804bac8f2c73df7fa64a62
Autor:
Shashank Dadsena, Svenja Bockelmann, John G. M. Mina, Dina G. Hassan, Sergei Korneev, Guilherme Razzera, Helene Jahn, Patrick Niekamp, Dagmar Müller, Markus Schneider, Fikadu G. Tafesse, Siewert J. Marrink, Manuel N. Melo, Joost C. M. Holthuis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Ceramides are lipids that act directly on mitochondria to trigger apoptosis, but the underlying mechanism remains largely unclear. Here authors use a photoactivatable ceramide probe combined with a computation approach and functional studies to ident
Externí odkaz:
https://doaj.org/article/161032635f8246f6afb463a1fd58d74b
Autor:
Patrick Niekamp, Gaelen Guzman, Hans C. Leier, Ali Rashidfarrokhi, Veronica Richina, Fabian Pott, Caroline Barisch, Joost C. M. Holthuis, Fikadu G. Tafesse
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Mycobacterium tuberculosisMtbMtb
Externí odkaz:
https://doaj.org/article/c10c9624a5e94da0b3613b77643ff8dc
Publikováno v:
Biological Chemistry. 404:467-490
Bilayered membranes separate cells from their surroundings and form boundaries between intracellular organelles and the cytosol. Gated transport of solutes across membranes enables cells to establish vital ion gradients and a sophisticated metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c6cce69c2fea6d1f65ab5ba21c1c382
https://doi.org/10.1515/hsz-2022-0321
https://doi.org/10.1515/hsz-2022-0321
Mitochondria depend on phospholipids supplied by the endoplasmic reticulum, but how these lipids cross the outer membrane to enter mitochondria is unclear. We identified the voltage-dependent ion channel (VDAC) as a scramblase that facilitates lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80828ca05678219ff882d99a98a98ba3
https://doi.org/10.1101/2022.10.17.512472
https://doi.org/10.1101/2022.10.17.512472
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The autophagy protein ATG2, proposed to transfer bulk lipid from the endoplasmic reticulum (ER) during autophagosome biogenesis, interacts with ER residents TMEM41B and VMP1 and with ATG9, in Golgi-derived vesicles that initiate autophagosome formati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4550aa3a601d851cf56dcb0fb4c85ce
https://doi.org/10.12703/r-01-0000015
https://doi.org/10.12703/r-01-0000015
Publikováno v:
FEBS Letters. 594:3739-3750
Mitochondrial translocation of ceramides triggers Bax-dependent apoptosis. To elucidate how ceramides activate Bax and commit cells to death, we developed a switchable version of the ceramide transfer protein CERT, sCERT. Upon its drug-induced recrui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075f7459e9d599d9368bd63acc704a22
https://doi.org/10.1002/1873-3468.13956
https://doi.org/10.1002/1873-3468.13956
Autor:
Zisis Koutsogiannis, John G. Mina, Christin A. Albus, Matthijs A. Kol, Joost C. M. Holthuis, Ehmke Pohl, Paul W. Denny
Toxoplasma gondii is an obligate, intracellular eukaryotic apicomplexan protozoan parasite that can cause foetal damage and abortion in both animals and humans. Sphingolipids have indispensable functions as signaling molecules and are essential and u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a51278a9839979c6b6a90b60cee02301
https://doi.org/10.1101/2022.01.05.475179
https://doi.org/10.1101/2022.01.05.475179
Autor:
Michael Philippi, Christian P. Richter, Marie Kappen, Isabelle Watrinet, Yi Miao, Mercedes Runge, Lara Jorde, Sergej Korneev, Michael Holtmannspötter, Rainer Kurre, Joost C. M. Holthuis, K. Christopher Garcia, Andreas Plückthun, Martin Steinhart, Jacob Piehler, Changjiang You
Publikováno v:
Small. 18:2270270
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6d96591cbd0a24681f12150eecf400d
https://doi.org/10.1002/smll.202270270
https://doi.org/10.1002/smll.202270270