Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation

Autor: Juan M. Ilarregui, Gijs Kooij, Ernesto Rodríguez, Susanne M. A. van der Pol, Nathalie Koning, Hakan Kalay, Joost C. van der Horst, Sandra J. van Vliet, Juan J. García-Vallejo, Helga E. de Vries, Yvette van Kooyk

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)

Abstract Background Multiple sclerosis (MS) involves a misdirected immune attack against myelin in the brain and spinal cord, leading to profound neuroinflammation and neurodegeneration. While the mechanisms of disease pathogenesis have been widely s

Externí odkaz: https://doaj.org/article/22f87aeffcb24a268513be628fe3e17d

MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma

Autor: Neha M. Sahasrabudhe, Joost C. van der Horst, Vivian Spaans, Gemma Kenter, Cor de Kroon, Tjalling Bosse, Sandra J. van Vliet, Ekaterina S. Jordanova

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

Cervical cancer is the fourth most common cancer type in women worldwide and is characterized by a highly immune-suppressive microenvironment. Here, we describe aberrant glycosylation as a factor mediating this immunosuppressive microenvironment. Exp

Externí odkaz: https://doaj.org/article/b32770edffd04bf3bfaf974593528907

Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

Autor: R. J. Eveline Li, Nicole C.T. van Grieken, Sjoerd T.T. Schetters, Thomas van Ee, Sven C. M. Bruijns, Kelly Boelaars, Ernesto Rodríguez, Matheus H.W. Crommentuijn, Laura J.W. Kruijssen, Elisa Giovannetti, Joost C. van der Horst, Kari Brown, Sandra J. van Vliet, Geert Kazemier, Juan J. Garcia-Vallejo, Yvette van Kooyk

Publikováno v: Rodriguez, E, Boelaars, K, Brown, K, Eveline Li, R J, Kruijssen, L, Bruijns, S C M, van Ee, T, Schetters, S T T, Crommentuijn, M H W, van der Horst, J C, van Grieken, N C T, van Vliet, S J, Kazemier, G, Giovannetti, E, Garcia-Vallejo, J J & van Kooyk, Y 2021, ' Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9 ', Nature Communications, vol. 12, no. 1, 1270 . https://doi.org/10.1038/s41467-021-21550-4
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, 12(1):1270. Nature Publishing Group

Changes in glycosylation during tumour progression are a key hallmark of cancer. One of the glycan moieties generally overexpressed in cancer are sialic acids, which can induce immunomodulatory properties via binding to Siglec receptors. We here show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a9d6c2a58db5a149a8cd1253b52843
https://doi.org/10.1038/s41467-021-21550-4

Oncogenic BRAFV600E drives expression of MGL ligands in the colorectal cancer cell line HT29 through N-acetylgalactosamine-transferase 3

Autor: Kristiaan Lenos, Joost C. van der Horst, Sandra J. van Vliet, Ernesto Rodríguez, Neha M. Sahasrabudhe

Publikováno v: Sahasrabudhe, N M, Lenos, K, van der Horst, J C, Rodríguez, E & van Vliet, S J 2018, ' Oncogenic BRAFV600E drives expression of MGL ligands in the colorectal cancer cell line HT29 through N-acetylgalactosamine-transferase 3 ', Biological Chemistry, vol. 399, no. 7, pp. 649-659 . https://doi.org/10.1515/hsz-2018-0120
Biological chemistry, 399(7), 649-659. Walter de Gruyter GmbH
Biological Chemistry, 399(7), 649-659. Walter de Gruyter GmbH

Colorectal cancer is the third most common cancer type worldwide. It is characterized by a high expression of aberrantly glycosylated ligands, such as the Tn antigen (GalNAcα1-Ser/Thr), which is a major ligand for the C-type lectin macrophage galact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8561baa56ed905ef66dfcb41b15e711c
https://doi.org/10.1515/hsz-2018-0120

MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma

Autor: Neha M. Sahasrabudhe, Joost C. van der Horst, Vivian Spaans, Gemma Kenter, Cor de Kroon, Tjalling Bosse, Sandra J. van Vliet, Ekaterina S. Jordanova

Publikováno v: Frontiers in Oncology
Frontiers in Oncology, 9
Frontiers in Oncology, Vol 9 (2019)
Sahasrabudhe, N M, van der Horst, J C, Spaans, V, Kenter, G, de Kroon, C, Bosse, T, van Vliet, S J & Jordanova, E S 2019, ' MGL ligand expression is correlated to lower survival and distant metastasis in cervical squamous cell and adenosquamous carcinoma ', Frontiers in Oncology, vol. 9, no. JAN, 29 . https://doi.org/10.3389/fonc.2019.00029
Frontiers in Oncology, 9(JAN):29. Frontiers Media S.A.

Cervical cancer is the fourth most common cancer in women worldwide and is characterized by a highly immune-suppressive microenvironment. Here, we describe aberrant glycosylation as a factor mediating this immunosuppressive microenvironment. Strong e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b1e3d9aace7fc72f48c14a3c6b0ef4
https://pubmed.ncbi.nlm.nih.gov/30761272