Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Joost B Beltman"'
Autor:
Muriel M Heldring, Lukas S Wijaya, Marije Niemeijer, Huan Yang, Talel Lakhal, Sylvia E Le Dévédec, Bob van de Water, Joost B Beltman
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 7, p e1010264 (2022)
Interindividual variability in DNA damage response (DDR) dynamics may evoke differences in susceptibility to cancer. However, pathway dynamics are often studied in cell lines as alternative to primary cells, disregarding variability. To compare DDR d
Externí odkaz:
https://doaj.org/article/bd05827ec19846e2a4c97f9f4699496c
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 7, p e1007972 (2020)
Although quantitative insights into the killing behaviour of Cytotoxic T Lymphocytes (CTLs) are necessary for the rational design of immune-based therapies, CTL killing function remains insufficiently characterised. One established model of CTL killi
Externí odkaz:
https://doaj.org/article/3d1267dd82ca426cb0c01ff066a721e0
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 2, p e1005954 (2018)
Tumors consist of a hierarchical population of cells that differ in their phenotype and genotype. This hierarchical organization of cells means that a few clones (i.e., cells and several generations of offspring) are abundant while most are rare, whi
Externí odkaz:
https://doaj.org/article/dd648e88c26c416ba1d89756a7664d38
Autor:
Johannes Textor, Sarah E Henrickson, Judith N Mandl, Ulrich H von Andrian, Jürgen Westermann, Rob J de Boer, Joost B Beltman
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 8, p e1003752 (2014)
To fight infections, rare T cells must quickly home to appropriate lymph nodes (LNs), and reliably localize the antigen (Ag) within them. The first challenge calls for rapid trafficking between LNs, whereas the second may require extensive search wit
Externí odkaz:
https://doaj.org/article/229a5459e6ff4cffa93b60e78b6ac2b6
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 11, p e1002763 (2012)
In many immunological processes chemoattraction is thought to play a role in guiding cells to their sites of action. However, based on in vivo two-photon microscopy experiments in the absence of cognate antigen, T cell migration in lymph nodes (LNs)
Externí odkaz:
https://doaj.org/article/bd547b215ced467bb8e29a855303130f
Autor:
Jos Urbanus, Jason Cosgrove, Joost B. Beltman, Yuval Elhanati, Rafael A. Moral, Cecile Conrad, Jeroen W. van Heijst, Emilie Tubeuf, Arno Velds, Lianne Kok, Candice Merle, Jens P. Magnusson, Léa Guyonnet, Jonas Frisén, Silvia Fre, Aleksandra M. Walczak, Thierry Mora, Heinz Jacobs, Ton N. Schumacher, Leïla Perié
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce immune cells are thought to decline in their regenerative capacity. However, HSPC
Externí odkaz:
https://doaj.org/article/59862cc7f88545bf963a5cd524bcd9f4
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Epithelial-mesenchymal transition (EMT) and immune resistance mediated by Programmed Death-Ligand 1 (PD-L1) upregulation are established drivers of tumor progression. Their bi-directional crosstalk has been proposed to facilitate tumor immunoevasion,
Externí odkaz:
https://doaj.org/article/cc17b7a0b83a4c5bbcf5d006a6bb64cc
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106666- (2023)
Summary: Cytotoxic T lymphocytes (CTLs) control tumors via lysis of antigen-presenting targets or through secretion of cytokines such as interferon-γ (IFNG), which inhibit tumor cell proliferation. Improved understanding of CTL interactions within s
Externí odkaz:
https://doaj.org/article/7d3c3274309642b8a3b7b1d2bbf4b8a8
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2199 (2023)
Nitrofurantoin (NFT) is a commonly used antibiotic for the treatment of urinary tract infections that can cause liver toxicity. Despite reports of hepatic adverse events associated with NFT exposure, there is still limited understanding of the interp
Externí odkaz:
https://doaj.org/article/658aa83d30304d5ca3f8f962a74c6934
Supplemental Video 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49187aa2daabae9cfba8dff893ee5bdf
https://doi.org/10.1158/0008-5472.22420832
https://doi.org/10.1158/0008-5472.22420832
