Zobrazeno 1 - 10
of 251
pro vyhledávání: '"Joost, Verhaagen"'
Autor:
Santiago Mora, Anna Stuckert, Rasmus von Huth Friis, Kimberly Pietersz, Gith Noes-Holt, Roser Montañana-Rosell, Haoyu Wang, Andreas Toft Sørensen, Raghavendra Selvan, Joost Verhaagen, Ilary Allodi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Loss of connectivity between spinal V1 inhibitory interneurons and motor neurons is found early in disease in the SOD1G93A mice. Such changes in premotor inputs can contribute to homeostatic imbalance of motor neurons. Here, we show that the
Externí odkaz:
https://doaj.org/article/2528f7f26b0f4d03a00277f90da7c3b6
Autor:
Luuk E. de Vries, Aldo Jongejan, Jennifer Monteiro Fortes, Rawien Balesar, Annemieke J. M. Rozemuller, Perry D. Moerland, Inge Huitinga, Dick F. Swaab, Joost Verhaagen
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer’s disease (AD). This phenomenon has been referred to as ‘resilience’. The molecular and cellular underpinnin
Externí odkaz:
https://doaj.org/article/e03528769b2a4a3cb0f3eb56cfdfb93b
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-33 (2024)
Abstract Some individuals are able to maintain their cognitive abilities despite the presence of significant Alzheimer’s Disease (AD) neuropathological changes. This discrepancy between cognition and pathology has been labeled as resilience and has
Externí odkaz:
https://doaj.org/article/366a52247abc420094a7a727d47c1fd6
Autor:
Santiago Mora, Anna Stuckert, Rasmus Von Huth-Friis, Kimberly Pietersz, Gith Noes-Holt, Roser Montañana-Rosell, Andreas Toft Sørensen, Joost Verhaagen, Raghavendra Selvan, Ilary Allodi
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S612-S613 (2023)
Externí odkaz:
https://doaj.org/article/b54d49907b7f427b9f8088b803d1091a
Autor:
Isaac Francos-Quijorna, Marina Sánchez-Petidier, Emily R. Burnside, Smaranda R. Badea, Abel Torres-Espin, Lucy Marshall, Fred de Winter, Joost Verhaagen, Victoria Moreno-Manzano, Elizabeth J. Bradbury
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Inflammation resolution failure is a pathological hallmark of spinal cord injury. Here, the authors show in rodents that chondroitin sulfate proteoglycans contribute to failed resolution by preventing immune cells at the injury core from converting t
Externí odkaz:
https://doaj.org/article/1fa069c153554f5aa4e6bb33426afeed
Autor:
Simone M. Crivelli, Qian Luo, Jo A.A. Stevens, Caterina Giovagnoni, Daan van Kruining, Gerard Bode, Sandra den Hoedt, Barbara Hobo, Anna-Lena Scheithauer, Jochen Walter, Monique T. Mulder, Christopher Exley, Matthew Mold, Michelle M. Mielke, Helga E. De Vries, Kristiaan Wouters, Daniel L. A. van den Hove, Dusan Berkes, María Dolores Ledesma, Joost Verhaagen, Mario Losen, Erhard Bieberich, Pilar Martinez-Martinez
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-21 (2021)
Abstract Background Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD). Ceramide transfer proteins (CERTs) are ceramide carriers which are crucial for ceramide and sp
Externí odkaz:
https://doaj.org/article/d634c5d563fa46608f8877609d288d6f
Autor:
Jeroen Melief, Marie Orre, Koen Bossers, Corbert G. van Eden, Karianne G. Schuurman, Matthew R. J. Mason, Joost Verhaagen, Jörg Hamann, Inge Huitinga
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract Inter-individual differences in cortisol production by the hypothalamus–pituitary–adrenal (HPA) axis are thought to contribute to clinical and pathological heterogeneity of multiple sclerosis (MS). At the same time, accumulating evidence
Externí odkaz:
https://doaj.org/article/91ae7c2831ea493c9b3564de0c282815
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Semaphorins, originally discovered as guidance cues for developing axons, are involved in many processes that shape the nervous system during development, from neuronal proliferation and migration to neuritogenesis and synapse formation. Interestingl
Externí odkaz:
https://doaj.org/article/f9cbba535eca437cb6466f767f5796d0
Autor:
Arie C van Vliet, Jinhui Lee, Marlijn van der Poel, Matthew R J Mason, Jasprina N Noordermeer, Lee G Fradkin, Martijn R Tannemaat, Martijn J A Malessy, Joost Verhaagen, Fred De Winter
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249748 (2021)
A human neuroma-in continuity (NIC), formed following a peripheral nerve lesion, impedes functional recovery. The molecular mechanisms that underlie the formation of a NIC are poorly understood. Here we show that the expression of multiple genes of t
Externí odkaz:
https://doaj.org/article/c7133a97562842fe8a06a7b4001c0c4e
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
A spinal root avulsion is the most severe proximal peripheral nerve lesion possible. Avulsion of ventral root filaments disconnects spinal motoneurons from their target muscles, resulting in complete paralysis. In patients that undergo brachial plexu
Externí odkaz:
https://doaj.org/article/2cf52272938f4dd3b280a6164cc148c4