Progesterone receptor distribution in the human hypothalamus and its association with suicide

Autor: Lin Zhang, Ronald W.H. Verwer, Joop van Heerikhuize, Paul J. Lucassen, Peter W. Nathanielsz, Elly M. Hol, Eleonora Aronica, Waljit S. Dhillo, Gerben Meynen, Dick F. Swaab

Publikováno v: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-14 (2024)

Abstract The human hypothalamus modulates mental health by balancing interactions between hormonal fluctuations and stress responses. Stress-induced progesterone release activates progesterone receptors (PR) in the human brain and triggers alteration

Externí odkaz: https://doaj.org/article/f3ec194bdc2c4ca6b6f0a9737f68b276

Different oxytocin and corticotropin-releasing hormone system changes in bipolar disorder and major depressive disorder patients

Autor: Lei Guo, Yang-Jian Qi, Hong Tan, Dan Dai, Rawien Balesar, Arja Sluiter, Joop van Heerikhuize, Shao-Hua Hu, Dick F. Swaab, Ai-Min Bao

Publikováno v: EBioMedicine, Vol 84, Iss , Pp 104266- (2022)

Summary: Background: Oxytocin (OXT) and corticotropin-releasing hormone (CRH) are both produced in hypothalamic paraventricular nucleus (PVN). Central CRH may cause depression-like symptoms, while peripheral higher OXT plasma levels were proposed to

Externí odkaz: https://doaj.org/article/9ad715b556a8455c8182c0721a5b7df8

Stress-associated purinergic receptors code for fatal suicidality in the hippocampal-hypothalamic-prefrontal circuit

Autor: Lin Zhang, Ronald W.H. Verwer, Joop van Heerikhuize, Rawien Balesar, Felipe Correa-da-Silva, Zala Slabe, Paul J. Lucassen, Dick F. Swaab

Imbalanced purine metabolism is a key neurological basis for suicide and mood disorders (MD), wherein purinergic receptors in stress-sensitive cerebral regions are thought to be differentially activated. A hippocampal network that links the hypothala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18e232da1abc912fe911cba6dfa812c1
https://doi.org/10.1101/2022.11.22.516142

Impaired fear extinction in serotonin transporter knockout rats is associated with increased 5-hydroxymethylcytosine in the amygdala

Autor: Ling Shan, Corina N. A. M. van den Heuvel, Hang‐Yuan Guo, Joop Van Heerikhuize, Judith R. Homberg

Publikováno v: CNS Neuroscience and Therapeutics, 24, 810-819. Wiley-Blackwell
CNS Neuroscience & Therapeutics
Cns Neuroscience & Thearapeutics, 24, 9, pp. 810-819
Cns Neuroscience & Thearapeutics, 24, 810-819

Summary Aims One potential risk factor for posttraumatic stress disorder (PTSD) involves the low activity (short; s) allelic variant of the serotonin transporter‐linked polymorphic region (5‐HTTLPR), possibly due to reduced prefrontal control ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47a9329c02d29383b7dd88178ed7960
https://pure.knaw.nl/portal/en/publications/fb5198ad-0e78-47bd-bc7a-a78deebcc13d

Increased Metabolic Activity in Nucleus Basalis of Meynert Neurons in Elderly Individuals With Mild Cognitive Impairment as Indicated by the Size of the Golgi Apparatus

Autor: Ronald W.H. Verwer, Wendela G. ter Meulen, Elliott J. Mufson, Joop Van Heerikhuize, Elisabeth J. G. Dubelaar, Dick F. Swaab

Publikováno v: Journal of neuropathology and experimental neurology, 65(3), 257-266. Lippincott Williams and Wilkins

In this study, we examined the metabolic activity of nucleus basalis of Meynert (NBM) neurons in individuals clinically diagnosed with no cognitive impairment (NCI, n = 8), mild cognitive impairment (MCI, n = 9), and subjects with moderate Alzheimer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586722c6947afc4375b8507918e34ebf
https://doi.org/10.1097/01.jnen.0000205143.16339.cd